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Phase 2Recruiting

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Sponsored by Merck Sharp & Dohme LLC

About this study

Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it

Where this study is enrolling (36)

  • Irvine Clinical Research ( Site 1041)

    Irvine, California

    Call 949-753-1663

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  • UCSF Memory and Aging Center ( Site 1031)

    San Francisco, California

    Call 415-353-3585

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  • Anderson Clinical Research ( Site 1024)

    Redlands, California

    Call 909-792-9007

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  • Syrentis Clinical Research ( Site 1001)

    Santa Ana, California

    Call 714-542-3008

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  • Healthy Brain Clinic ( Site 1005)

    Long Beach, California

    Call 562-606-5999

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Show all 36 locations

  • Inglewood Clinical ( Site 1062)

    Los Angeles, California

    Call 949-265-1612

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  • Yale University, Alzheimer's Disease Research Unit ( Site 1059)

    New Haven, Connecticut

    Call 203-764-8100

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  • Suncoast Clinical Research ( Site 1007)

    New Port Richey, Florida

    Call 727-849-4131

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  • Renstar Medical Research ( Site 1012)

    Ocala, Florida

    Call 352-629-5800

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  • Charter Research - Lady Lake ( Site 1019)

    The Villages, Florida

    Call 352-775-1000

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  • Charter Research - Orlando ( Site 1051)

    Orlando, Florida

    Call 407-337-3000

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  • ClinCloud LLC ( Site 1039)

    Melbourne, Florida

    Call 407-680-0534

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  • Neuropsychiatric Research Center of Southwest Florida ( Site 1003)

    Fort Myers, Florida

    Call 239-939-7777

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  • Conquest Research LLC ( Site 1053)

    Winter Park, Florida

    Call 407-916-0060

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  • K2 Medical Research ( Site 1047)

    Maitland, Florida

    Call 407-500-5252

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  • Axiom Brain Health ( Site 1029)

    Tampa, Florida

    Call 813-353-9613

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  • JEM Research Institute ( Site 1046)

    Atlantis, Florida

    Call 561-968-2933

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  • K2 Medical Research ( Site 1020)

    Tampa, Florida

    Call 813-800-5252

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  • Indago Research and Health Center Inc ( Site 1044)

    Miami Lakes, Florida

    Call 305-825-6588

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  • Aqualane Clinical Research ( Site 1035)

    Naples, Florida

    Call 239-529-6780

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  • CenExel iResearch, LLC ( Site 1015)

    Decatur, Georgia

    Call 404-537-1281

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  • Alexian Brothers Medical Center-Neurosciences ( Site 1017)

    Elk Grove Village, Illinois

    Call 847-593-8553

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  • Boston Center for Memory ( Site 1008)

    Newton, Massachusetts

    Call 617-699-6927

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  • Clinical Research Professionals ( Site 1004)

    Chesterfield, Missouri

    Call 636-220-1200

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  • CenExel- AMRI ( Site 1018)

    Toms River, New Jersey

    Call 732-341-9500

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  • The Cognitive and Research Center of New Jersey - Ridgewood ( Site 1064)

    Ridgewood, New Jersey

    Call 201-850-4622

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  • The Cognitive and Research Center of NJ ( Site 1057)

    Springfield, New Jersey

    Call 973-850-4622

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  • Alzheimer Disease Research Center (ADRC) ( Site 1000)

    Albany, New York

    Call 518-426-0575

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  • Mid Hudson Medical Research ( Site 1050)

    New Windsor, New York

    Call 845-674-9398

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  • Basil Clinical ( Site 1065)

    Queens, New York

    Call 917-672-3275

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  • AMC Research, LLC ( Site 1006)

    Matthews, North Carolina

    Call 704-364-4000

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  • Insight Clinical Trials ( Site 1011)

    Independence, Ohio

    Call 216-245-6556

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  • Neuro-Behavioral Clinical Research ( Site 1028)

    North Canton, Ohio

    Call 330-493-1118

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  • Flourish Research ( Site 1048)

    Plymouth Meeting, Pennsylvania

    Call 610-277-8073

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  • Gadolin Research ( Site 1032)

    Beaumont, Texas

    Call 409-331-6040

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  • Horizon Clinical Research Center - Houston ( Site 1026)

    Cypress, Texas

    Call 949-491-0710

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Who can participate

Inclusion criteria

  • ✓The main inclusion criteria include but are not limited to the following:
  • ✓Has mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD)
  • ✓Has a designated study partner who can fulfill the requirements of this study
  • ✓If on an approved AD therapy for symptomatic AD, the dosing regimen must have been stable for 3 months prior to screening

Exclusion criteria

  • ✕The main exclusion criteria include but are not limited to the following:
  • ✕Has a known history of stroke or cerebrovascular disease
  • ✕Has diagnosis of a clinically relevant central nervous system disease other than AD or other condition that negatively impacts cognition or cognitive status chronically
  • ✕Has structural brain disease
  • ✕Has a history of seizures or epilepsy within 5 years before screening
  • ✕Has any other major central nervous system trauma, or infections that affect brain function
  • ✕Has major medical illness or unstable medical condition within 3 months before screening
  • ✕Has a severe, acute, or chronic medical or psychiatric condition or laboratory abnormality
  • ✕Has any immunological disease, which is not adequately controlled, or which requires treatment with biologics and/or immunosuppressants during the study
  • ✕Has a bleeding disorder that is not under adequate control
  • ✕Has a history of malignancy occurring within 5 years of screening
  • ✕Has a risk factor for corrected QT interval (QTc) prolongation
  • ✕Has liver disease
  • ✕Is unwilling or unable to undergo computed tomography (CT), positron emission tomography (PET), or magnetic resonance imaging (MRI) scan
  • ✕Resides in a nursing home or assisted care facility with need for direct continuous medical care and nursing supervision

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.