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Phase 2Recruiting

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Sponsored by Eli Lilly and Company

About this study

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.

Where this study is enrolling (36)

  • The Institute for Liver Health II dba Arizona Liver Health-Tucson

    Tucson, Arizona

    I'm interested

  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

    Chandler, Arizona

    Call 480-360-4000

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  • Headlands Research - Scottsdale

    Scottsdale, Arizona

    I'm interested

  • Diablo Clinical Research, Inc.

    Walnut Creek, California

    Call 925-930-7267

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  • Peninsula Research Associates

    Rolling Hills Estates, California

    Call 310-265-1623

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Show all 36 locations

  • Velocity Clinical Research, Huntington Park

    Huntington Park, California

    Call 323-588-1990

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  • NorCal Medical Research, Inc

    Greenbrae, California

    Call 415-461-1585

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  • New Horizon Research Center

    Miami, Florida

    Call 305-226-3933

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  • Charter Research - Lady Lake

    The Villages, Florida

    Call 352-441-2000

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  • Charter Research - Winter Park

    Orlando, Florida

    Call 407-337-3000

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  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida

    Call 727-849-4131

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  • Indago Research & Health Center, Inc

    Miami Lakes, Florida

    Call 305-825-6588

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  • Medical Research Partners

    Ammon, Idaho

    Call 208-681-9070

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  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa

    Call 515-329-6800

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  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, Kansas

    Call 785-354-9591

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  • Monroe Biomedical Research - Louisville

    Louisville, Kentucky

    Call 502-515-5672

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  • Lucida Clinical Trials

    New Bedford, Massachusetts

    Call 508-720-2015

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  • Knownwell

    Needham, Massachusetts

    Call 339-793-8998

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  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan

    Call 248-312-0025

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  • StudyMetrix Research

    City of Saint Peters, Missouri

    Call 636-387-5100

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  • Las Vegas Medical Research

    Las Vegas, Nevada

    Call 702-750-0000

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  • Rochester Clinical Research, LLC

    Rochester, New York

    Call 585-288-0890

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  • Monroe Biomedical Research

    Monroe, North Carolina

    Call 704-283-7359

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  • Medication Management

    Greensboro, North Carolina

    Call 336-763-6968

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  • Lucas Research, Inc.

    New Bern, North Carolina

    Call 252-649-1944

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  • Lucas Research, Inc

    Morehead City, North Carolina

    Call 252-222-5700

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  • CTI Clinical Research Center

    Cincinnati, Ohio

    Call 513-721-3868

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  • Tribe Clinical Research, LLC

    Greenville, South Carolina

    Call 864-334-0141

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  • Quality Medical Research

    Nashville, Tennessee

    Call 615-835-4750

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  • Texas Valley Clinical Research

    Weslaco, Texas

    Call 956-431-8090

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  • FutureSearch Trials of Dallas

    Dallas, Texas

    Call 214-369-2600

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  • IMA Clinical Research Austin

    Austin, Texas

    Call 512-649-0082

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  • Endeavor Clinical Trials

    San Antonio, Texas

    Call 518-428-6859

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  • PlanIt Research, PLLC

    Houston, Texas

    I'm interested

  • Sovah Clinical Research-River District

    Danville, Virginia

    Call 434-793-4711

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  • Central Washington Health Services Association d/b/a Confluence Health

    Wenatchee, Washington

    Call 509-436-4050

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Who can participate

Inclusion criteria

  • ✓Have a body mass index (BMI)
  • ✓≥30 kilogram/square meter (kg/m²), or
  • ✓≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
  • ✓Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.

Exclusion criteria

  • ✕Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
  • ✕Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
  • ✕Have poorly controlled hypertension.
  • ✕Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
  • ✕Have any of the following cardiovascular conditions within 3 months prior to screening:
  • ✕acute myocardial infarction
  • ✕cerebrovascular accident (stroke)
  • ✕unstable angina, or
  • ✕hospitalization due to congestive heart failure.
  • ✕Have a history of symptomatic gallbladder disease within the past 2 years.
  • ✕Have a lifetime history of suicide attempts.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.