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A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

Sponsored by Eli Lilly and Company

About this study

The main purpose of this study is to assess if different dose levels of Brenipatide are safe and work the way they are intended to work in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), when compared with placebo. The study will last approximately one year.

Where this study is enrolling (13)

  • University of Alabama at Birmingham

    Birmingham, Alabama

    Call 484-707-6813

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  • Institute of HealthCare Assessment d/b/a Apex Clinical Research

    San Diego, California

    Call 619-582-5564

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  • NewportNativeMD, Inc.

    Newport Beach, California

    Call 949-791-8599

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  • Deluxe Health Center

    Miami Lakes, Florida

    Call 305-209-1268

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  • Florida Institute For Clinical Research, LLC

    Orlando, Florida

    Call 407-658-0966

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Show all 13 locations

  • Indiana University Health University Hospital

    Indianapolis, Indiana

    Call 317-278-0099

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  • Brigham and Women's Hospital

    Boston, Massachusetts

    Call 617-732-8201

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  • Revive Research Institute, Inc.

    Southfield, Michigan

    Call 248-829-3103

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  • Clinical Research Associates of Central PA

    DuBois, Pennsylvania

    Call 814-940-1212

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  • Baylor College of Medicine Medical Center

    Houston, Texas

    I'm interested

  • Premier Pulmonary Critical Care and Sleep

    Denison, Texas

    Call 469-714-9864

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  • Prime Clinical Research - Lewisville

    Lewisville, Texas

    Call 817-907-7330

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  • Paramount Clinical Research - Data Point Clinical Research

    Kirkland, Washington

    Call 425-577-1107

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Who can participate

Inclusion criteria

  • ✓Have a physician diagnosis of Chronic Obstructive Pulmonary Disease (COPD), at least 12 months prior to screening who meet the following criteria:
  • ✓Current or former smokers with a smoking history of greater than or equal to (≥) 10 pack-years
  • ✓Moderate-to-severe COPD (post-Bronchodilator (BD) Forced Expiratory Volume in 1 Second (FEV₁)/forced vital capacity (FVC) less than (\<) 70 percent (%)
  • ✓Modified Medical Research Council Dyspnea Scale (mMRC-DS) grade ≥2
  • ✓Exacerbation history of ≥2 moderate or ≥1 severe exacerbations within the year prior to inclusion.
  • ✓Background double therapy \[long-acting β₂-agonists (LABA) + long-acting muscarinic antagonists (LAMA)\] or triple therapy \[inhaled corticosteroids (ICS) + LABA + LAMA)\] for 3 months prior to randomization with a stable dose of medication for ≥1 month prior to screening.

Exclusion criteria

  • ✕Have a known pre-existing, clinically important lung condition other than COPD.
  • ✕Have a current or recent acute, active infection before screening and up to randomization.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.