A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
Sponsored by Eli Lilly and Company
About this study
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event. Participation in the study will last about 9 months.
Where this study is enrolling (21)
- Call 256-519-8472
Heart Center Research, LLC
Huntsville, Alabama
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- I'm interested
Eclipse Clinical Research
Tucson, Arizona
- Call 520-838-3540
Pima Heart
Tucson, Arizona
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- Call 626-727-7254
Thrive Clinical Research Group
Glendora, California
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- Call 386-668-4202
Omega Research Orlando
Altamonte Springs, Florida
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Show all 21 locations
- Call 407-658-0966
Florida Institute For Clinical Research, LLC
Orlando, Florida
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- Call 407-810-2790
K2 Medical Research - Maitland
Maitland, Florida
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- Call 678-494-5735
North Georgia Clinical Research
Woodstock, Georgia
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- Call 662-893-8474
Olive Branch Family Medical Center
Olive Branch, Mississippi
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- Call 702-680-1500
Excel Clinical Research, LLC
Las Vegas, Nevada
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- Call 702-736-5161
Palm Research Center Tenaya
Las Vegas, Nevada
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- Call 716-415-8380
Rochester Clinical Research - Buffalo
Buffalo, New York
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- Call 347-270-1111
CHEAR Center LLC
The Bronx, New York
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- Call 513-671-8080
Velocity Clinical Research, Cincinnati, Springdale
Cincinnati, Ohio
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- Call 215-321-7400
Cardiology Consultants of Philadelphia Yardley
Yardley, Pennsylvania
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- Call 803-766-2680
Monroe Biomedical Research - Charleston
North Charleston, South Carolina
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- Call 949-491-0710
Horizon Clinical Research Group
Cypress, Texas
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- Call 214-544-7555
Texas Institute of Cardiology, PA
McKinney, Texas
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- Call (713) 791-1978
Cardiovascular Specialists of Willowbrook
Houston, Texas
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- Call 385-271-0684
Ogden Clinic - Canyon View
Ogden, Utah
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- Call 703-335-8750
Carient Heart & Vascular - Manassas
Manassas, Virginia
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Who can participate
Inclusion criteria
- ✓hsCRP ≥2 mg/L and ≤15 mg/L at screening
- ✓At least one of the following chronic conditions:
- ✓Established atherosclerotic cardiovascular disease (ASCVD)
- ✓Obesity (body mass index (BMI) ≥30 kg/m2)
- ✓Type 2 diabetes
- ✓Hypertension
- ✓Chronic kidney disease Grade 3 or 4
Exclusion criteria
- ✕Acute cardiovascular event within 60 days prior to screening
- ✕Acute decompensated heart failure hospitalization within 60 days prior to screening
- ✕Planned coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or major surgery at the time of randomization
- ✕New York Heart Association Class III or IV heart failure
- ✕Uncontrolled hypertension at screening (systolic blood pressure (BP) ≥160 mmHg or diastolic BP ≥100 mmHg)
- ✕Type 1 diabetes
- ✕Type 2 diabetes with Hemoglobin A1c ≥9.0% (86 mmol/mol) at screening
- ✕Nephrotic syndrome, estimated glomerular filtration rate (eGFR) \<15 mL/min/1.73 m², or history of kidney transplant
- ✕Dialysis or acute kidney injury within 60 days prior to screening
- ✕Congenital/hereditary kidney disease, polycystic kidney disease, lupus nephritis, or antineutrophil cytoplasmic antibody-associated vasculitis
- ✕Active tuberculosis, untreated latent tuberculosis, or known hepatitis B or hepatitis C infection
- ✕Serious, opportunistic, chronic, or recurrent infection requiring treatment within 12 weeks prior to screening
- ✕Significant active autoimmune disease
- ✕Suspected or confirmed immunocompromised state (e.g., HIV infection)
- ✕History of peptic ulcer disease or gastrointestinal ulceration within 12 months prior to screening
- ✕History of diverticular disease, gastrointestinal perforation, or major gastrointestinal surgery
- ✕Mechanical heart valve prosthesis requiring chronic vitamin K antagonist anticoagulation
- ✕Use of colchicine within 14 days prior to screening or anticipated need during the study
- ✕Use of immunosuppressive or immunomodulatory agents, including other biologic anti-IL-6 therapies, within specified windows prior to screening
- ✕Use of systemic corticosteroids within 14 days prior to screening
- ✕Chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs)
Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.
Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.