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Phase 3Recruiting

A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Sponsored by Eli Lilly and Company

About this study

The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight. YDAO is a master protocol designed to support two independent studies: YSA1 and YSA2. Study YSA1 will include participants who are unable or unwilling to use Positive Airway Pressure (PAP) therapy and study YSA2 will include participants who are on PAP therapy for at least 3 months at time of screening and plan to continue PAP therapy during the study. Participants will be assigned to the Intervention-Specific Appendix (ISA) that reflects their current PAP usage. Participation in the study will last about 76 weeks.

Where this study is enrolling (19)

  • Cullman Clinical Trials

    Cullman, Alabama

    Call 256-708-2826

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  • Collaborative Neuroscience Research, LLC

    Los Alamitos, California

    Call 714-799-7799

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  • Artemis Institute for Clinical Research

    Riverside, California

    Call 951-374-1190

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  • Ark Clinical Research

    Long Beach, California

    Call 562-997-1000

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  • Care Access - Aurora

    Aurora, Colorado

    Call 720-368-4865

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Show all 19 locations

  • Emerald Coast Neurology - Airport Boulevard

    Pensacola, Florida

    Call 850-438-1136

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  • Flourish Research - Miami, LLC

    Miami, Florida

    Call 305-631-6704

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  • PharmaDev Clinical Research Institute, LLC

    Miami, Florida

    Call 305-420-5636

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  • EBGS Clinical Research Center

    Snellville, Georgia

    Call 770-729-4517

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  • Care Access - Shreveport 2

    Shreveport, Louisiana

    Call 318-209-3290

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  • Flourish Research - Bowie

    Bowie, Maryland

    Call 410-824-1342

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  • Revive Research Institute, Inc.

    Southfield, Michigan

    Call 248-829-3103

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  • Clayton Sleep Institute - St. Louis - Tesson Ferry Road

    St Louis, Missouri

    Call 314-645-6005

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  • Palm Research Center Tenaya

    Las Vegas, Nevada

    Call 702-736-5161

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  • The Sleep Spot - Maimonides

    Albuquerque, New Mexico

    Call 505-998-7200

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  • CTI Clinical Research Center

    Cincinnati, Ohio

    Call 513-721-3868

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  • Bogan Sleep Consultants

    Columbia, South Carolina

    Call 803-251-3093

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  • FutureSearch Trials of Neurology

    Austin, Texas

    Call 512-380-9925

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  • Consano Clinical Research, LLC

    Shavano Park, Texas

    Call 210-545-4900

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Who can participate

Inclusion criteria

  • ✓Confirmed history of moderate-to-severe OSA
  • ✓Have an AHI ≥ 15 on polysomnography (PSG) as part of the study at screening
  • ✓Have a BMI ≥27 kg/m2 at screening
  • ✓Have a stable body weight (\<5% body weight change) for 90 days prior to screening
  • ✓Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight
  • ✓For YSA1 Participants:
  • ✓Are unable or unwilling to use PAP therapy
  • ✓For YSA2 Participants:
  • ✓Have been on PAP therapy for at least three consecutive months prior to screening and plan to continue PAP therapy during the study

Exclusion criteria

  • ✕Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
  • ✕Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • ✕Any previous or planned surgery for sleep apnea or major ear, nose or throat surgery that still may affect breathing at time of screening
  • ✕Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • ✕Have had within 90 days prior to screening:
  • ✕acute myocardial infarction
  • ✕cerebrovascular accident (stroke)
  • ✕coronary artery revascularization
  • ✕unstable angina, or
  • ✕hospitalization due to congestive heart failure
  • ✕Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • ✕Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.