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Phase 2Recruiting

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Sponsored by Eli Lilly and Company

About this study

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

Where this study is enrolling (24)

  • Helios Clinical Research - Phoenix

    Phoenix, Arizona

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  • Wolverine Clinical Trials

    Santa Ana, California

    Call 714-617-2426

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  • Oviedo Medical Research

    Oviedo, Florida

    Call 407-977-2705

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  • Renstar Medical Research

    Ocala, Florida

    Call 3526295800

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  • North Georgia Clinical Research

    Woodstock, Georgia

    Call 6784945735

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Show all 24 locations

  • Balanced Life Health Care Solutions/SKYCRNG

    Lawrenceville, Georgia

    Call 770-696-4541

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  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia

    Call 470-317-3604

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  • Physicians Research Associates

    Lawrenceville, Georgia

    Call 678-252-2375

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  • Elite Clinical Trials

    Rexburg, Idaho

    Call 208 356-8977

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  • Investigators Research Group

    Brownsburg, Indiana

    Call 3178528280

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  • Clinical Research of Philadelphia

    Pennington, New Jersey

    Call 215-676-6696

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  • NYC Research INC

    Long Island City, New York

    Call 516-574-9232

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  • Southgate Medical Group

    West Seneca, New York

    Call 7167121004

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  • Lucas Research, Inc.

    Morehead City, North Carolina

    Call 252-222-5700

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  • Shelby Clinical Research

    Shelby, North Carolina

    Call 9805529230

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  • Providence Health Partners-Center for Clinical Research

    Dayton, Ohio

    Call 937-297-8994

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  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma

    Call 4057018999

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  • Frontier Clinical Research, LLC

    Scottdale, Pennsylvania

    Call 724-220-5281

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  • Juno Research

    Houston, Texas

    Call (713) 779-5494

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  • Southern Endocrinology Associates

    Mesquite, Texas

    Call 214-693-0904

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  • Consano Clinical Research, LLC

    Shavano Park, Texas

    Call 210-545-4900

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  • Texas Diabetes & Endocrinology, P.A.

    Round Rock, Texas

    Call 512-334-3505

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  • Texas Valley Clinical Research

    Weslaco, Texas

    Call 956-431-8090

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  • Eastside Research Associates

    Redmond, Washington

    Call 4258696828

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Who can participate

Inclusion criteria

  • ✓Have type 2 diabetes
  • ✓Have HbA1c ≥7.5% to ≤10.5% at screening
  • ✓Have a body mass index (BMI) of ≥27 kilograms per square meter (kg/m2) at screening
  • ✓Have had a stable body weight for the three months prior to screening
  • ✓On stable treatment dose of one of the following incretins for at least three months prior to screening:
  • ✓Injectable semaglutide (1 and 2 milligram (mg))
  • ✓Injectable tirzepatide (5, 7.5, 10, 12.5 and 15 mg)

Exclusion criteria

  • ✕Have type 1 diabetes, latent autoimmune diabetes, or history of ketoacidosis or hyperosmolar coma
  • ✕Have a prior or planned surgical treatment for obesity
  • ✕Have any of the following cardiovascular conditions within three months prior to screening:
  • ✕acute myocardial infarction
  • ✕cerebrovascular accident (stroke)
  • ✕unstable angina, or
  • ✕hospitalization due to congestive heart failure
  • ✕Have used insulin to control blood glucose within the past year (short-term use allowed)
  • ✕Current use of prohibited oral antihyperglycemic medication (OAM) (including but not limited to, Dipeptidyl Peptidase IV Inhibitors (DPP-4i) and meglitinides) may be randomized if the prohibited OAM treatment was discontinued at least 3 months prior to screening
  • ✕If participant has been on stable doses (for at least three months) of up to three permitted OAMs (limited to metformin, sodium-glucose cotransporter-2 (SGLT2) inhibitors, alpha-glucosidase inhibitors, sulfonylurea, and/or thiazolidinediones (TZD), they are permitted to participate in the study
  • ✕Have taken any medications or alternative remedies for weight loss within three months prior to screening

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.