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Phase 2Recruiting

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Sponsored by Eli Lilly and Company

About this study

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

Where this study is enrolling (22)

  • Synexus Clinical Research US, Inc.

    Phoenix, Arizona

    Call +1 602-200-3814

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  • Pima Heart

    Tucson, Arizona

    Call 520-838-3540

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  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC

    Gilbert, Arizona

    I'm interested

  • AGILE Clinical Research Trials, LLC

    Sandy Springs, Georgia

    I'm interested

  • SKY Clinical Research Network Group-Brown

    Atlanta, Georgia

    I'm interested
Show all 22 locations

  • Pivotal Research Solutions

    Stonecrest, Georgia

    Call 678-825-2887

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  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia

    Call 470-317-3604

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  • Vector Clinical Trials

    Las Vegas, Nevada

    Call 702-750-0000

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  • Premier Research

    Trenton, New Jersey

    Call 609-392-6666

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  • PriMED Clinical Research

    Dayton, Ohio

    Call 937-534-4201

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  • Biopharma Informatic, LLC

    Houston, Texas

    I'm interested

  • Consano Clinical Research, LLC

    Shavano Park, Texas

    Call 210-545-4900

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  • Mercy Family Clinic

    Dallas, Texas

    Call 281-944-3610

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  • PlanIt Research, PLLC

    Houston, Texas

    I'm interested

  • Research Physicians Network, LLC

    Houston, Texas

    Call 281-944-3610

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  • Texas Valley Clinical Research

    Weslaco, Texas

    Call 956-431-8090

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  • Aavon Clinical Trials

    Richmond, Texas

    Call 713-282-5600

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  • Kalo Clinical Research

    West Valley City, Utah

    Call 801-363-7353

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  • Eastern Virginia Medical School (EVMS) Medical Group

    Norfolk, Virginia

    Call 757-446-5291

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  • Clinical Research Partners, LLC

    Richmond, Virginia

    Call 804-477-3045

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  • Universal Research Group

    Tacoma, Washington

    Call 253-882-1070

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  • Rainier Clinical Research Center

    Renton, Washington

    Call 425-251-1720

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Who can participate

Inclusion criteria

  • ✓Have type 2 diabetes
  • ✓Have an HbA1c ≥7.5% to ≤10.5% at screening
  • ✓Have been treated with any of the following, alone or in combination, for at least 3 months prior to screening
  • ✓Diet and exercise
  • ✓Stable dose of metformin
  • ✓Sodium-glucose cotransporter-2 (SGLT2) inhibitor
  • ✓Have had a stable body weight (\<5% body weight gain and/or loss) for the 3 months prior to screening
  • ✓Have a BMI of 27 or greater at screening

Exclusion criteria

  • ✕Have any form of diabetes other than type 2 diabetes
  • ✕Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening
  • ✕Have any of the following cardiovascular conditions within 3 months prior to screening:
  • ✕acute myocardial infarction
  • ✕cerebrovascular accident (stroke)
  • ✕unstable angina, or
  • ✕hospitalization due to congestive heart failure
  • ✕Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years, exceptions include
  • ✕basal or squamous cell skin cancer
  • ✕in situ carcinomas of the cervix, or
  • ✕in situ prostate cancer
  • ✕Have been prescribed any of the following receptor agonists (RA) or their combination for any indication within the last 6 months:
  • ✕amylin RA
  • ✕dual amylin and calcitonin RA
  • ✕glucagon-like peptide-1 receptor (GLP-1) RA
  • ✕glucose-dependent insulinotropic peptide (GIP)/GLP-1 RA
  • ✕GLP-1/glucagon (GCG) RAs, or
  • ✕GIP/GLP-1/GCG RAs
  • ✕Have used excluded antihyperglycemic medications within 3 months prior to screening (including, but not limited to, sulfonylureas, dipeptidyl peptidase-4 inhibitors, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides
  • ✕Have used insulin for diabetic control within the prior year (short term use in certain situations allowed

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.