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Phase 3Recruiting

A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis

Sponsored by Zenas BioPharma (USA), LLC

About this study

Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of orelabrutinib compared with placebo in patients with non-active Secondary Progress MS. Patients will be treated for approximately 24 to 60 months, with a minimum treatment duration of 12 months. The study will enroll approximately 990 subjects in a 2:1 randomization (orelabrutinib: placebo), globally.

Enrolling at this location

Arizona Neuroscience Research, LLC

Phoenix, Arizona

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This study also enrolls at 21 other locations. See all.

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Trial data sourced from ClinicalTrials.gov.