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Phase 3Recruiting

A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight

Sponsored by Eli Lilly and Company

About this study

The GZPS master protocol will support two independent studies, J2A-MC-GZS1 and J2A-MC-GZS2. Each study will see how well and safely orforglipron works in adult female participants with stress urinary incontinence (SUI) who have obesity or overweight. SUI is leaking urine during movement or activity such as coughing or exercising. Participation in the study will last about 58 weeks from screening to safety follow-up.

Where this study is enrolling (13)

  • Urologic Surgeons of Arizona

    Mesa, Arizona

    Call (480) 409-5060

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  • Matrix Clinical Research

    Los Angeles, California

    Call 310-424-5922

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  • Colorado Clinical Research

    Lakewood, Colorado

    Call 303-996-9649

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  • AMR Clinical

    Fort Myers, Florida

    Call 239-936-4421

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  • Altus Research

    Lake Worth, Florida

    Call 561-641-0404

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Show all 13 locations

  • New Age Medical Research Corporation

    Miami, Florida

    Call 305-596-9901

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  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan

    Call 248-312-0025

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  • Clinical Research of Philadelphia

    Philadelphia, Pennsylvania

    I'm interested

  • Next Level Urgent Care

    Houston, Texas

    I'm interested

  • Innovative Medical Research of Texas

    Houston, Texas

    I'm interested

  • Health Research of Hampton Roads, Inc.

    Newport News, Virginia

    Call 757-591-8100

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  • Seattle Clinical Research Center

    Seattle, Washington

    Call 206-522-3330

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  • Northwest Clinical Research Center

    Bellevue, Washington

    Call 877-453-0404

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Who can participate

Inclusion criteria

  • ✓Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
  • ✓Have a diagnosis of stress urinary incontinence

Exclusion criteria

  • ✕Have had urinary incontinence surgery
  • ✕Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
  • ✕Have given birth within one year of screening
  • ✕Have had a change in body weight of more than 11 pounds within 90 days prior to screening
  • ✕Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening
  • ✕Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • ✕Have had a cardiovascular health condition within 90 days prior to screening
  • ✕Are pregnant, intending to be pregnant, breastfeeding, or intending to breastfeed for the duration of the study

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.