Back to Clinical Trials
Phase 3Recruiting

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

Sponsored by Eli Lilly and Company

About this study

This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and dyslipidemia, and progression to class 1 obesity.

Where this study is enrolling (68)

  • Cahaba Research - Pelham

    Pelham, Alabama

    Call 205-408-4134

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Pinnacle Research Group, LLC

    Anniston, Alabama

    Call 256-236-0055

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Central Research Associates

    Birmingham, Alabama

    Call 205-327-1077

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Synexus Clinical Research US, Inc./Orange Grove Family Practice

    Tucson, Arizona

    Call 520-333-4515

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - 801 South Power Road, Mesa

    Mesa, Arizona

    Call 877-791-0656

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

Show all 68 locations

  • Artemis Institute for Clinical Research

    Riverside, California

    Call 951-374-1190

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Norcal Endocrinology & Internal Medicine

    San Ramon, California

    Call 925-552-5280

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Riverside Clinical

    Riverside, California

    Call 951-374-8000

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Los Angeles Institute for Metabolic Research

    Los Angeles, California

    Call 213-373-8380

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Healthy Brain Clinic

    Long Beach, California

    Call 562-606-5999

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Headlands Research- Sacramento

    Sacramento, California

    Call 916-434-8230

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Diablo Clinical Research, Inc.

    Walnut Creek, California

    Call 925-930-7267

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Desert Oasis Healthcare Medical Group

    Palm Springs, California

    Call 760-320-9505

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Orange County Research Center

    Lake Forest, California

    Call 714-550-9990

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Chase Medical Research, LLC

    Waterbury, Connecticut

    Call 203-419-4420

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Yale University School of Medicine

    New Haven, Connecticut

    Call 203-785-7421

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - St. Petersburg

    St. Petersburg, Florida

    Call 877-791-0656

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • New Age Medical Research Corporation

    Miami, Florida

    Call 305-596-9901

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Headlands Research Orlando

    Orlando, Florida

    Call 407-705-3471

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Flourish Research Acquisition, LLC dba Flourish Research - North Miami

    Miami, Florida

    Call 786-772-0411

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Oviedo Medical Research

    Oviedo, Florida

    Call 407-977-2705

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Excel Medical Clinical Trials

    Boca Raton, Florida

    Call 305-631-6704

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Renstar Medical Research

    Ocala, Florida

    Call 352-629-5800

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - Dalton Walmart

    Dalton, Georgia

    Call 877-791-0656

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • HOPE Clinical Research & Wellness

    Conyers, Georgia

    Call 770-679-5591

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - Decatur

    Decatur, Georgia

    Call 617-843-2781

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • SKY Clinical Research Network Group-Brown

    Atlanta, Georgia

    I'm interested

  • Solaris Clinical Research

    Meridian, Idaho

    Call 208-288-0123

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Family First Medical Center

    Idaho Falls, Idaho

    Call 208-552-7700

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, Illinois

    I'm interested

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa

    Call 515-329-6800

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Cotton O'Neil Clinical Research Center

    Topeka, Kansas

    Call 785-354-9591

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Monroe Biomedical Research - Louisville

    Louisville, Kentucky

    Call 502-515-5672

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • IMA Clinical Research Monroe-Main

    Monroe, Louisiana

    Call 318-737-1098

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana

    Call 225-763-2578

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Centennial Medical Group

    Columbia, Maryland

    Call 443-698-8678

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Brigham and Women's Hospital Diabetes Program

    Boston, Massachusetts

    Call 617-732-4245

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Great Lakes Research Group, Inc.

    Bay City, Michigan

    Call 989-895-9100

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan

    Call 248-312-0025

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Clinvest Headlands Llc

    Springfield, Missouri

    Call 417-883-7889

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • M3 Wake Research - Las Vegas Cimarron

    Las Vegas, Nevada

    Call 702-893-8968

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Renascor Clinical Research

    Reno, Nevada

    Call 775-544-0376

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Drug Trials America

    Hartsdale, New York

    Call 914-341-2346

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Rochester Clinical Research, LLC

    Rochester, New York

    Call 585-288-0890

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • NYC Research INC

    Long Island City, New York

    Call 516-574-9232

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • West Clinical Research

    Morehead City, North Carolina

    Call 252-515-0050

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Medication Management

    Greensboro, North Carolina

    Call 336-763-6968

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Lillestol Research

    Fargo, North Dakota

    Call 701-232-7705

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Remington-Davis, Inc

    Columbus, Ohio

    Call 614-487-2560

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Central States Research

    Tulsa, Oklahoma

    Call 918-645-5400

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Clinical Renal Associates Ltd.

    Media, Pennsylvania

    Call 610-872-8501

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - Mauldin

    Mauldin, South Carolina

    Call 864-202-6290

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • New Phase Research and Development

    Knoxville, Tennessee

    Call 865-200-8364

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Clinical Research Associates Inc

    Nashville, Tennessee

    Call 615-329-0197

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Biopharma Informatic, LLC

    Houston, Texas

    I'm interested

  • VIP Trials

    San Antonio, Texas

    Call 210-569-2672

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Cedar Health Research - Euless

    Euless, Texas

    Call 214-253-8170

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Cedar Health Research - Texas Native Health

    Dallas, Texas

    Call 214-253-8170

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • IMA Clinical Research San Antonio

    San Antonio, Texas

    Call 210-692-7157

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Headlands Research-El Paso

    El Paso, Texas

    Call 915-910-7088

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - Houston - Clinical Trials Center by Walmart & Care Access

    Houston, Texas

    Call 617-843-2781

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • DCOL Center for Clinical Research

    Longview, Texas

    Call 903-238-8854

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Consano Clinical Research, LLC

    Shavano Park, Texas

    Call 210-545-4900

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Activian Clinical Research

    Kingwood, Texas

    Call 832-969-3401

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Care Access - Tyler - Clinical Trials Center by Walmart & Care Access

    Tyler, Texas

    Call 877-791-0656

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Clinical Research Partners, LLC

    Richmond, Virginia

    Call 804-477-3045

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Sovah Clinical Research-River District

    Danville, Virginia

    Call 434-793-4711

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Frontier Clinical Research, LLC

    Kingwood, West Virginia

    Call 304-441-2006

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

Who can participate

Inclusion criteria

  • ✓Have an increased waist-to-height ratio of ≥0.5
  • ✓Have at least one pre-obesity-related complication (prediabetes, prehypertension, predyslipidemia)
  • ✓Have at least one unsuccessful attempt to reduce body weight based on diet and exercise
  • ✓Have a BMI greater than or equal to 25 to less than or equal to 29.9 kg/m2 or equivalent-/region-specific overweight thresholds

Exclusion criteria

  • ✕Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • ✕Do not have a stable body weight within 90 days before screening
  • ✕Have a documented obesity diagnosis or self-reported history of BMI ≥30 kg/m² (or an equivalent region-specific threshold)
  • ✕Have taken medications for weight loss, including over-the counter medications or alternative therapies, within 180 days prior to screening
  • ✕Have a prior or planned surgical treatment or procedure for obesity
  • ✕Have hypertension or history of hypertension
  • ✕Have dyslipidemia or history of dyslipidemia

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.