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Phase 3Recruiting

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Sponsored by Eli Lilly and Company

About this study

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.

Where this study is enrolling (23)

  • AMR Clinical

    Tempe, Arizona

    I'm interested

  • Arizona Research Center

    Phoenix, Arizona

    I'm interested

  • Care Access - Thousand Oaks

    Thousand Oaks, California

    Call 805-778-5143

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  • Care Access - Huntington Beach

    Huntington Beach, California

    Call 714-378-2440

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  • Legacy Clinical Trials

    Colorado Springs, Colorado

    Call 719-387-7572

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Show all 23 locations

  • Chase Medical Research, LLC

    Waterbury, Connecticut

    Call 203-419-4420

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  • Care Access - Decatur

    Decatur, Georgia

    Call 617-843-2781

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  • North Georgia Clinical Research

    Woodstock, Georgia

    Call 678-494-5735

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  • Northwestern University

    Chicago, Illinois

    I'm interested

  • AMR Clinical

    Newton, Kansas

    Call 316-804-7304

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  • MedVadis Research Corporation

    Waltham, Massachusetts

    Call 617-744-1310

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  • StudyMetrix Research

    City of Saint Peters, Missouri

    Call 636-387-5100

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  • Cardio Metabolic Institute

    Somerset, New Jersey

    Call 732-846-7000 x 108

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  • Carolina Research Center

    Shelby, North Carolina

    Call 704-600-6052

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  • Care Access - Rapid City

    Rapid City, South Dakota

    Call 877-791-0656

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  • AMR Clinical

    Knoxville, Tennessee

    Call 865-305-9100

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  • Mercy Family Clinic

    Dallas, Texas

    Call 281-944-3610

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  • Biopharma Informatic, LLC

    Houston, Texas

    I'm interested

  • Activian Clinical Research

    Kingwood, Texas

    Call 832-969-3401

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  • Juno Research

    Houston, Texas

    Call (713) 779-5494

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  • Advanced Rheumatology of Houston - Woodlands

    The Woodlands, Texas

    I'm interested

  • Charlottesville Medical Research

    Charlottesville, Virginia

    Call 434-817-2442

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  • Gershon Pain Specialists

    Virginia Beach, Virginia

    Call 757-496-2050

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Who can participate

Inclusion criteria

  • ✓Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
  • ✓Have tried at least once to lose weight through diet but were unsuccessful
  • ✓Have osteoarthritis of the knee and at least one of the following conditions:
  • ✓Be over 50 years old
  • ✓Have morning knee stiffness that lasts about 30 minutes
  • ✓Have a crackling or grinding sound or feeling in the knee

Exclusion criteria

  • ✕Have gained or lost more than 11 pounds within 90 days prior to screening
  • ✕Have had a surgery for obesity or plan to have one in the next 18 months
  • ✕Have an active knee infection
  • ✕Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • ✕Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure
  • ✕Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.