Back to Clinical Trials
Phase 1Recruiting

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

Sponsored by Amgen

About this study

The primary objective for dose exploration and dose expansion is to evaluate the safety and tolerability of tarlatamab in combination with AB248. The primary objective for dose exploration only is to determine the recommended dose for expansion and/or maximum tolerated combination dose (MTCD) of AB248 in combination with tarlatamab.

Where this study is enrolling (2)

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona

    Call +1 480-256-6444

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Emory University

    Atlanta, Georgia

    I'm interested
Who can participate

Inclusion criteria

  • ✓1. Participant has provided informed consent before initiation of any study-specific activities/procedures.
  • ✓2. Participants ≥ 18 years (or ≥ legal age within the country if it is older than 18 years) at the time of signing the informed consent.
  • ✓3. Participants with histologically or cytologically confirmed ES-SCLC that has progressed or recurred following at least 1 line of anti-cancer therapy for ES-SCLC.
  • ✓4. Participants must have at least 1 measurable lesion as defined by RECIST 1.1 within 21-day screening period, not previously irradiated.
  • ✓5. Participants must have adequate organ function (hematological, coagulation, cardiac, pulmonary, kidney, and liver).
  • ✓6. Participants must submit a fresh tumor biopsy at screening unless a new biopsy cannot be performed safely or is infeasible. Participants who cannot provide fresh tissue may provide archival tissue that was collected after last anticancer therapy.

Exclusion criteria

  • ✕1. Symptomatic central nervous system (CNS) metastases.
  • ✕2. Participants with brain metastases may be eligible if criteria defined in the protocol are met.
  • ✕3. Prior therapy with any delta-like ligand 3 (DLL3)-directed therapy (including tarlatamab).
  • ✕4. Prior interleukin (IL)-2, IL-7 or IL-15 targeted therapy.
  • ✕5. Baseline (at rest) requirement of supplemental oxygen.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.