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Phase 3Recruiting

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

Sponsored by Takeda

About this study

Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO). The main aim of the study is to know how well zasocitinib (TAK-279) works in participants with active PsA who have not previously been treated with biologic disease-modifying antirheumatic drugs. The participants will be treated with either zasocitinib, active comparator, or placebo. Participants will be in the study for up to 60 weeks.

Where this study is enrolling (46)

Show all 46 locations

  • First OC Dermatology Research Inc.

    Fountain Valley, California

    I'm interested

  • Foothill Arthritis Clinic

    Tujunga, California

    I'm interested

  • Denver Arthritis Clinic | Denver, CO

    Denver, Colorado

    I'm interested

  • RASF- Clinical Research Center

    Boca Raton, Florida

    I'm interested

  • Arthritis & Rheumatic Disease Specialties (AARDS)

    Aventura, Florida

    I'm interested

  • Bioresearch Partners

    Miami, Florida

    I'm interested

  • Clinical Research of West Florida | Clearwater, FL

    Clearwater, Florida

    I'm interested

  • Clinical Research of West Florida | Tampa, FL

    Tampa, Florida

    I'm interested

  • GNP Research, LLC | Hollywood, FL

    Cooper City, Florida

    I'm interested

  • IRIS Research and Development | Plantation, FL

    Plantation, Florida

    I'm interested

  • Millennium Research | Ormond Beach, FL

    Ormond Beach, Florida

    I'm interested

  • Sarasota Arthritis Research Center

    Sarasota, Florida

    I'm interested

  • Sweet Hope Research Specialty, Inc, d/b/a Neoclinical Research

    Hialeah, Florida

    I'm interested

  • Tectum Medical Research

    Davie, Florida

    I'm interested

  • West Broward Rheumatology Associates, Inc.

    Tamarac, Florida

    I'm interested

  • Marietta Rheumatology Associates

    Marietta, Georgia

    I'm interested

  • Greater Chicago Specialty Physicians LLC/CIS

    Schaumburg, Illinois

    I'm interested

  • GSCP/CIS

    Orland Park, Illinois

    I'm interested

  • Accurate Clinical Research, Inc. | Lake Charles

    Lake Charles, Louisiana

    I'm interested

  • Klein & Associates, M.D., P.A.

    Hagerstown, Maryland

    I'm interested

  • June DO, PC Private Practice - Dr. Justus Fiechtner

    Lansing, Michigan

    I'm interested

  • Clinical Research Institute of Michigan

    Saint Clair Shores, Michigan

    I'm interested

  • Michigan Rheumatology Group, P.C. - Grand Blanc Office

    Grand Blanc, Michigan

    I'm interested

  • Ash Research Clinic - Howell

    Howell, Michigan

    I'm interested

  • Saint Louis Rheumatology

    St Louis, Missouri

    I'm interested

  • Santa Fe Rheumatology

    Santa Fe, New Mexico

    I'm interested

  • Albuquerque Center for Rheumatology PC

    Albuquerque, New Mexico

    I'm interested

  • NYU Langone Health | Joseph S. and Diane H. Steinberg Ambulatory Care Center - Rheumatology Department

    Brooklyn, New York

    I'm interested

  • Accellacare of Hickory

    Hickory, North Carolina

    I'm interested

  • Paramount Medical Research & Consulting, LLC

    Middleburg Heights, Ohio

    I'm interested

  • University Hospitals | UH Cleveland Medical Center - Department of Medicine - Rheumatology Division

    Cleveland, Ohio

    I'm interested

  • PA Regional Center for Arthritis and Osteoporosis Research

    Wyomissing, Pennsylvania

    I'm interested

  • West Tennessee Research Institute

    Jackson, Tennessee

    I'm interested

  • Clinical Investigations of Texas

    Plano, Texas

    I'm interested

  • Southwest Rheumatology Research, LLC | Mesquite, TX

    Mesquite, Texas

    I'm interested

  • Accurate Clinical Research

    Baytown, Texas

    I'm interested

  • Introscience Research | Northwest Houston Arthritis Center - Houston, TX

    Houston, Texas

    I'm interested

  • Novel Research | Bellaire Location

    Bellaire, Texas

    I'm interested

  • Accurate Clinical Research

    Houston, Texas

    I'm interested

  • West Texas Clinical Research

    Lubbock, Texas

    I'm interested

  • Arthritis Northwest, PLLC | Spokane, WA

    Spokane, Washington

    I'm interested
Who can participate

Inclusion criteria

  • ✓1. The participant is aged 18 years or older at the time of signing the informed consent form (ICF). In South Korea, the age requirement for adult participants is \>=19 years of age.
  • ✓Disease Characteristics:
  • ✓2. The participant has a diagnosis of PsA.
  • ✓3. The participant must have signs and symptoms of PsA for at least 3 months prior to screening.
  • ✓4. The participant meets the Classification Criteria for Psoriatic Arthritis (CASPAR criteria).
  • ✓5. The participant has active arthritis as shown by a minimum of \>=3 tender joints in TJC68 and \>=3 swollen joints in SJC66 at the screening and baseline (Day 1) visits.
  • ✓6. The participant has at least 1 active lesion of plaque PsO \>=2 cm in diameter, or any nail or nail bed changes characteristic of PsO.
  • ✓Medications for PsA:
  • ✓7. The participant has had at least one of the following:
  • ✓1. Inadequate response to a nonsteroidal anti-inflammatory drug (NSAID) (not applicable in the European Union \[EU\]/ European Economic Area \[EEA\]), OR
  • ✓2. Inadequate response to a conventional synthetic disease-modifying antirheumatic drug (csDMARD).

Exclusion criteria

  • ✕PsA and PsO:
  • ✕1. The participant has other disease(s) that might confound the evaluations of benefit of zasocitinib therapy, including but not limited to rheumatoid arthritis, axial spondyloarthritis, systemic lupus erythematosus, Lyme disease, gout, or fibromyalgia.
  • ✕2. The participant has a concomitant comorbid skin condition that, in the opinion of the investigator, would interfere with the study assessments, such as evidence of non-plaque PsO (erythrodermic, pustular, predominately guttate PsO, inverse, or drug-induced PsO).

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.