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Phase 3Recruiting

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

Sponsored by Karuna Therapeutics, Inc., a Bristol Myers Squibb company

About this study

The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.

Where this study is enrolling (43)

  • Gilbert Neurology Partners - PLLC - Avacare

    Gilbert, Arizona

    Call 480-926-0644

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  • Banner Alzheimer's Institute

    Phoenix, Arizona

    Call 602-839-6900

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  • Advanced Research Center, Inc.

    Anaheim, California

    Call 714-999-6688

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  • Inland Psychiatric Medical Group (IPMG)-Chino

    Chino, California

    Call 909-488-9116

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  • USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC)

    Los Angeles, California

    Call 323-442-3715

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Show all 43 locations

  • University of Connecticut Health Center

    Farmington, Connecticut

    Call 860-790-7354

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  • Nova Psychiatry

    Orlando, Florida

    Call 407-823-8421

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  • Charter Research

    The Villages, Florida

    Call 352-775-1000

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  • Envision Trials LLC

    Bonita Springs, Florida

    Call 305-819-2909

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  • Arrow Clinical Trials

    Daytona Beach, Florida

    Call 386-278-8000

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  • Aqualane Clinical Research

    Naples, Florida

    Call 941-436-6838

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  • Sensible HealthCare, LLC

    Ocoee, Florida

    Call 407-654-2724

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  • Combined Research Orlando Phase I-IV LLC

    Orlando, Florida

    Call 407-440-4493

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  • Guardian Angel Research

    Tampa, Florida

    Call 813-300-3300

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  • Interventional Psychiatry of Tampa Bay

    Tampa, Florida

    Call 813-251-1800

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  • Premiere Research Institute at Palm Beach Neurology, PA

    West Palm Beach, Florida

    Call 561-845-0500

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  • Agile Clinical Research Trials, LLC

    Atlanta, Georgia

    I'm interested

  • Boston Neuro Research Center

    North Dartmouth, Massachusetts

    Call 508-925-7403

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  • Elixia Health - Springfield - Elixia - PPDS

    Springfield, Massachusetts

    Call 413-305-1142

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  • Tufts Medical Center - 800 Washington St - PPDS

    Boston, Massachusetts

    Call 617-636-3202

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  • McLean Hospital

    Belmont, Massachusetts

    Call 617-855-2136

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  • Neurobehavioral Medicine Group (NBMG)

    Bloomfield Township, Michigan

    Call 412-916-2425

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  • Precise Research Centers

    Flowood, Mississippi

    Call 601-420-5810

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  • Tekton Research, LLC - Saint Louis Psychiatry - PPDS

    St Louis, Missouri

    Call 314-594-7785

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  • Advanced Memory Research Institute - CenExel - PPDS

    Toms River, New Jersey

    Call 732-341-9500

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  • SUNY Upstate Medical University

    Syracuse, New York

    Call 617-636-5000

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  • Mid Hudson Medical Research PLLC

    New Windsor, New York

    Call 845-674-9398

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  • Five Towns Neurology, PC

    Woodmere, New York

    Call 516-239-1800

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  • West Clinical Research

    Morehead City, North Carolina

    Call 252-515-0050

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  • Triad Clinical Trials - 515 College Rd

    Greensboro, North Carolina

    Call 336-235-0991

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  • AMC Research, LLC - Flourish - PPDS

    Matthews, North Carolina

    Call 704-364-4000

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  • Insight Clinical Trials LLC - Independence

    Independence, Ohio

    Call 216-444-8897

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  • Ohio State University

    Columbus, Ohio

    Call 614-293-4560

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  • The Rivus Wellness & Research Institute

    Oklahoma City, Oklahoma

    Call 405-317-5783

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  • Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital

    Providence, Rhode Island

    Call 714-456-7002

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  • Vanderbilt Psychiatric Hospital

    Nashville, Tennessee

    Call 615-322-4967

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  • Senior Adults Specialty Research

    Austin, Texas

    Call 512-407-8628

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  • Epic Medical Research LLC - DeSoto

    DeSoto, Texas

    Call 972-777-6956

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  • Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases

    San Antonio, Texas

    Call 210-567-8229

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  • University Hills Clinical Research - 102 Decker Ct

    Irving, Texas

    Call 972-717-6262

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  • Advanced Neuro Research Center - El Paso

    El Paso, Texas

    Call 915-974-2200

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  • Conquest Research, LLC - Virginia - Vienna

    Vienna, Virginia

    Call 703-717-7755

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  • Northwest Clinical Research Center

    Bellevue, Washington

    Call 425-453-0404

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Who can participate

Inclusion criteria

  • ✓Patients who are 55 to 90 years of age, inclusive, at the time of Screening (Visit 1).
  • ✓Patients who are diagnosed with AD based on the 2024 revised criteria for diagnosis and staging of AD: Alzheimer's Association Workgroup.
  • ✓Patient must have a magnetic resonance imaging (MRI) or computed tomography (CT) scan of the brain (completed within the past 5 years) taken during or subsequent to the onset of dementia to rule out other central nervous system (CNS) disease that could account for the dementia syndrome, eg, major stroke, neoplasm, subdural hematoma.
  • ✓Patient must have a history of psychotic symptoms (meeting International Psychogeriatric Association criteria) for at least 2 months prior to Screening (Visit 1) (participants may or may not have symptoms of agitation).

Exclusion criteria

  • ✕\- Patients will not be able to participate if they have:
  • ✕i) Psychotic symptoms that are primarily attributable to a condition other than the AD causing the dementia, eg, schizophrenia, schizoaffective disorder, delusional disorder, or mood disorder with psychotic features.
  • ✕ii) History of major depressive episode with psychotic features during the 12 months prior to Screening, or history of bipolar disorder, schizophrenia, or schizoaffective disorder.
  • ✕iii) Patients are not able to participate if they have certain safety concerns, including certain laboratory test irregularities.
  • ✕\* Other protocol-defined Inclusion/Exclusion criteria apply.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.