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Phase 3Recruiting

A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis

Sponsored by Bristol-Myers Squibb

About this study

The purpose of this study is to evaluate the efficacy, safety, and drug levels of Deucravacitinib (BMS-986165) in adolescent participants with moderate to severe plaque psoriasis

Where this study is enrolling (25)

  • Center For Dermatology Clinical Research, Inc.

    Fremont, California

    Call 510-599-4750

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  • Northridge Clinical Trials

    Northridge, California

    Call 818-350-7483

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  • Dermatology Research Associates

    Los Angeles, California

    Call 310-337-7171

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  • Golden State Dermatology - Walnut Creek - Ygnacio Valley Road

    Walnut Creek, California

    Call 507-261-3758

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  • Paradigm Clinical Research, LLC

    Wheat Ridge, Colorado

    Call 303-463-1947

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Show all 25 locations

  • Life Clinical Trials

    Margate, Florida

    Call 954-849-0902

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  • USF Health

    Tampa, Florida

    Call 813-974-4381

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  • Skin Research of South Florida

    Miami, Florida

    Call 305-707-9852

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  • Wellness Clinical Research

    Miami Lakes, Florida

    Call 786-483-7856

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  • MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research

    Tampa, Florida

    Call 813-948-7550

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  • Advanced Medical Research, PC.

    Sandy Springs, Georgia

    Call 404-939-9220

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  • Dermatology Affiliates Research Institute

    Atlanta, Georgia

    Call 770-733-1077

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  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana

    Call 317-516-5030

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  • Dermatology and Skin Cancer Specialists, LLC

    Rockville, Maryland

    Call 301-355-3183

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  • Kuchnir Dermatology & Dermatologic Surgery

    Milford, Massachusetts

    Call 000-000-0000

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  • Henry Ford Medical Center

    Detroit, Michigan

    Call 248-884-5356

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  • C.S. Mott Clinical Research Center (CRC)

    Detroit, Michigan

    Call 248-581-5243

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  • Dermatology and Skin Cancer Center

    Lee's Summit, Missouri

    Call 913-451-7546

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  • JDR Dermatology Research

    Las Vegas, Nevada

    Call 702-596-6137

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  • Apex Clinical Research Center - Canton

    Canton, Ohio

    Call 14404404430440

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  • Apex Clinical Research Center

    Mayfield Heights, Ohio

    Call 440-940-2739

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  • Paddington Testing Company

    Philadelphia, Pennsylvania

    Call 215-563-7330

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  • ObjectiveHealth - Goodlettsville Dermatology Research

    Goodlettsville, Tennessee

    Call 615-241-2820

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  • Texas Dermatology and Laser Specialists

    San Antonio, Texas

    Call 210-704-4037

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  • Frontier Derm Partners

    Mill Creek, Washington

    Call 425-275-4404

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Who can participate

Inclusion criteria

  • ✓Participants must have stable plaque psoriasis for 6 months or more prior to Screening.
  • ✓Participants must have moderate to severe psoriasis defined by:.
  • ✓i) Psoriasis Area and Severity Index (PASI) ≥ 12, at screening visit and Day 1.
  • ✓ii) Static Physician's Global Assessment (sPGA) ≥ 3, at screening visit and Day 1.
  • ✓iii) Body Surface Area (BSA) ≥ 10% involvement, at screening visit and Day 1.
  • ✓\- A female (as assigned at birth) participant is eligible to participate if she is not pregnant or breastfeeding, and at least 1 of the following conditions applies:.
  • ✓i) Is not an individual of childbearing potential (IOCBP).
  • ✓ii) Is an IOCBP and using a contraceptive method that is highly effective (with a failure rate of \< 1% per year) during the study intervention period and for at least 3 days after discontinuation of the study intervention and agrees not to donate eggs (ova, oocytes) for the purpose of reproduction for the same period.

Exclusion criteria

  • ✕Participants must not weigh \< 30.0 kg at Screening and Day 1.
  • ✕Participants must not have non-plaque psoriasis (ie, guttate, inverse, pustular, erythrodermic, or drug-induced psoriasis) or any skin condition other than plaque psoriasis that could interfere with assessments of treatment effect at Screening or Day 1.
  • ✕Participants must not have a history of serious bacterial, fungal, or viral infection requiring hospitalization and intravenous (IV) antimicrobial treatment within 60 days prior to Day 1.
  • ✕Participants must not have any untreated bacterial infection within 60 days prior to Day 1.
  • ✕Participants must not have any ongoing evidence of chronic bacterial infection (eg, chronic pyelonephritis, chronic osteomyelitis, chronic bronchiectasis).
  • ✕Participants must not have herpes simplex/zoster, active tuberculosis (TB), hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV) infection-related exclusions.
  • ✕Participants must not have received live vaccines or BCG within 60 days prior to Day 1 or plans to receive a live vaccine during the study, or within 60 days after completing study intervention.
  • ✕Participants must not have had any prior exposure to deucravacitinib.
  • ✕Participants must not have received any medication that is specifically prohibited.
  • ✕Participants must not have a laboratory finding that is exclusionary.
  • ✕Participants must not have any major illness/condition or evidence of an unstable clinical condition (eg, renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, psychiatric, neurologic, immunologic, or local active infection/infectious illness) that, in the investigator's judgment or after consultation with the Sponsor's Medical Monitor, will substantially increase the risk to the participant if he or she participates in the study.
  • ✕Participants must not have cancer or history of cancer (solid organ or hematologic including myelodysplastic syndrome) or lymphoproliferative disease within the previous 5 years.
  • ✕Other protocol-defined Inclusion/Exclusion criteria apply.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.