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Phase 3Recruiting

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

Sponsored by Bristol-Myers Squibb

About this study

The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in participants with agitation associated with Alzheimer's Disease who completed the parent studies CN012-0023 or CN012-0024.

Where this study is enrolling (9)

  • Imaging Endpoints

    Scottsdale, Arizona

    I'm interested

  • Nuovida Research Center

    Miami, Florida

    Call 786-616-9853

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  • Progressive Medical Research

    Port Orange, Florida

    Call 386-304-7070

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  • Hope Research Network - Miami

    Virginia Gardens, Florida

    Call 786-681-4959

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  • IPTB Clinical Research

    Tampa, Florida

    Call 813-251-1800

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Show all 9 locations

  • Boston Center for Memory

    Newton, Massachusetts

    Call 413-281-0577

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  • Redbird Research

    Las Vegas, Nevada

    Call 760-758-2222

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  • West Clinical Research

    Morehead City, North Carolina

    Call 252-515-0050

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  • Epic Medical Research, LLC - Carrolton

    Carrollton, Texas

    Call 972-782-2405

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Who can participate

Inclusion criteria

  • ✓Participants must have completed study CN012-0023 or CN012-0024 per protocol.
  • ✓Participants must have an identified caregiver who has sufficient contact (approximately 8 hours over a week).

Exclusion criteria

  • ✕Participants must not have clinically significant cardiovascular (eg, untreated or unstable hypertension, clinically significant tachycardia), pulmonary, renal, hematologic, GI, endocrine, immunologic, dermatologic, neurologic, or oncologic disease or any other condition that, in the opinion of the investigator, would jeopardize the safety of the participant or the validity of the study results.
  • ✕Other protocol-defined Inclusion/Exclusion criteria apply.

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Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.