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Phase 4Recruiting

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Sponsored by Eli Lilly and Company

About this study

The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

Where this study is enrolling (32)

  • Medical Dermatology Specialists

    Phoenix, Arizona

    I'm interested

  • Northridge Clinical Trials

    Northridge, California

    Call 818-350-7482

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  • Center For Dermatology Clinical Research, Inc.

    Fremont, California

    Call 510-797-0140

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  • First OC Dermatology Research Inc

    Fountain Valley, California

    Call 714-531-2966

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  • Metropolis Dermatology

    Los Angeles, California

    Call 424-393-0005

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Show all 32 locations

  • Encore Medical Research

    Hollywood, Florida

    Call 954-400-1725

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  • Skin Care Research

    Hollywood, Florida

    Call 954-674-3535

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  • NeoClinical Research

    Hialeah, Florida

    Call 305-456-9062

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  • MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research

    Tampa, Florida

    Call 813-948-7550

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  • Southeast Research Specialists

    Douglasville, Georgia

    Call 678-702-3376

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  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana

    Call 317-516-5030

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  • The Indiana Clinical Trials Center, PC

    Plainfield, Indiana

    Call 317-837-6082

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  • Equity Medical - Bowling Green

    Bowling Green, Kentucky

    Call 270-213-7777

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  • The Derm Institute of West Michigan

    Caledonia, Michigan

    Call 616-326-0114

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  • David Fivenson, MD, PLC

    Ann Arbor, Michigan

    Call 734-222-9630

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  • Skin Cancer and Dermatology Institute - Reno

    Reno, Nevada

    Call 775-336-3658

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  • Stracskin

    Portsmouth, New Hampshire

    Call 617-833-9995

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  • Care Access - Hoboken

    Hoboken, New Jersey

    Call 551-278-8680

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  • Equity Medical

    New York, New York

    Call 212-466-6550

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  • Onsite Clinical Solutions - Huntersville

    Huntersville, North Carolina

    Call 800-785-3150

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  • Optima Research - Boardman

    Boardman, Ohio

    Call 330-422-3234

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  • Oregon Dermatology and Research Center

    Portland, Oregon

    Call 503-226-3376

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  • Columbia Dermatology & Aesthetics

    Columbia, South Carolina

    Call 803-731-9600

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  • DelRicht Research - Thompson's Station

    Smyrna, Tennessee

    Call 629-895-1775

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  • Austin Institute for Clinical Research

    Pflugerville, Texas

    Call 512-279-2545

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  • Bellaire Dermatology Associates

    Bellaire, Texas

    Call 713-661-4383

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  • Modern Research Associates, PLLC

    Dallas, Texas

    Call 214-361-2008

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  • Center for Clinical Studies

    Houston, Texas

    I'm interested

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas

    Call 210-852-2779

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  • Center for Clinical Studies

    Webster, Texas

    Call 281-333-2288

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  • Dermatology of Seattle

    Burien, Washington

    Call 206-248-5020

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  • Bellevue Dermatology Clinic

    Bellevue, Washington

    Call 425-455-2275

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Who can participate

Inclusion criteria

  • ✓Have a diagnosis of moderate-to-severe plaque PsO, as defined by a dermatologist or other experienced clinician treated PsO (for example, allergologist, nurse practitioner or physician assistant)
  • ✓Have body mass index (BMI) of 30 kilograms per meter squared (kg/m²) or greater (obesity) or 27 kg/m² to \<30 kg/m² (overweight) in the presence of at least 1 weight-related comorbid condition (hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea, or cardiovascular diseases).
  • ✓Must have initiated treatment with ixekizumab for approximately 3 months (± 1 month) prior to decision to add tirzepatide.
  • ✓Must be able to initiate tirzepatide (Day 0) within 30 days of treatment decision (baseline/screening).

Exclusion criteria

  • ✕Have currently received ixekizumab for more than 4 months or less than 2 months.
  • ✕Have had any exposure to tirzepatide or other glucagon-like peptide-1 receptor agonist (GLP-1 RAs), for example, dulaglutide, liraglutide, or semaglutide.
  • ✕Are currently enrolled in any other clinical study.
  • ✕Other exclusions
  • ✕Have a known hypersensitivity to tirzepatide or to any of its component.
  • ✕Have a personal or family history of medullary thyroid cancer.
  • ✕Have multiple endocrine neoplasia type 2.
  • ✕Have type I diabetes mellitus.
  • ✕Have a history of chronic or acute pancreatitis at any time before screening (Visit 1).
  • ✕Have a history of proliferative diabetic retinopathy, diabetic maculopathy, or nonproliferative diabetic retinopathy that requires acute treatment.
  • ✕Have a history of ketoacidosis or hyperosmolar state/coma.
  • ✕Have a history of severe hypoglycemia and hypoglycemia unawareness within the 6 months before screening.
  • ✕Have a history of severe gastrointestinal complications, including gastroparesis, gastroesophageal reflux disease, dyspepsia, chronic nausea/constipation/vomiting.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.