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Phase 2Recruiting

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Sponsored by Pfizer

About this study

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

All participants in this study will take either the study medicine (PF-07328948) tablets, or placebo tablets, once daily, by mouth, every day for 36 weeks. The study determines if the study medicine (PF-07328948) is safe and effective compared to placebo in people with heart failure who are already taking standard-of-care medications for heart failure that include sodium-glucose cotransporter 2 (SGLT2) inhibitors. Participants will be involved in this study for about 48 weeks. During this time, participants will visit the study clinic 15 times. In general, 5 of these visits may be performed at home by phone and the other 10 visits will take place at the study site.

Where this study is enrolling (5)

  • Northwestern University

    Evanston, Illinois

    I'm interested

  • Northwestern Memorial Hospital Investigational Drug Service (IDS)

    Chicago, Illinois

    Call 312.926.2000

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  • Northwestern Memorial HealthCare - Galter Pavilion

    Chicago, Illinois

    Call 312.926.2000

    This research site can be reached directly by phone. Call to ask about this study.

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  • Northwestern Memorial HealthCare - Feinberg Pavilion

    Chicago, Illinois

    Call 312.926.2000

    This research site can be reached directly by phone. Call to ask about this study.

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  • Northwestern Memorial HealthCare - Arkes Pavilion

    Chicago, Illinois

    Call 312.926.2000

    This research site can be reached directly by phone. Call to ask about this study.

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Who can participate

Inclusion criteria

  • ✓include:
  • ✓aged 18 years to \< 80 years
  • ✓clinically confirmed to have a diagnosis of heart failure for at least 3 months
  • ✓New York Heart Association Class II-IV symptoms
  • ✓left ventricular ejection fraction greater than 40%
  • ✓Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
  • ✓Six-minute walking distance greater than 75 meters

Exclusion criteria

  • ✕include:
  • ✕Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
  • ✕Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
  • ✕History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
  • ✕Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.