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Adverse Outcomes and Mortality in Liver Transplant

Sponsored by Mayo Clinic

About this study

Prospective natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.

Sarcopenia, characterized by the progressive loss of muscle volume and function, is a common and major complication in end-stage liver disease which significantly contributes to adverse outcomes and mortality as well as hampers successful outcomes for treatments such as liver transplant (LT). High resolution image-based techniques have been instrumental in furthering our understanding of body composition in sarcopenia specifically and human health in general. While several methods exist to evaluate body composition, imaging techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI) enable capitalization of images taken as part of standard practice as well as append already clinical examinations with brief sequences tailored for mapping muscle and body composition. Op…

Where this study is enrolling

  • Mayo Clinic Arizona

    Phoenix, Arizona

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Who can participate

Inclusion criteria

  • ✓1. All patients with end-stage liver disease undergoing evaluation for liver transplantation
  • ✓2. Patient clinically indicated for MRI during transplant candidacy evaluation
  • ✓3. Adult

Exclusion criteria

  • ✕1\. Contra indication to MRI

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Trial data sourced from ClinicalTrials.gov.