Blood Pressure Variability and Ischemic Stroke Outcome
Sponsored by Yale University
About this study
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.
Increased blood pressure variability (BPV) has consistently been associated with two to three times higher risk of disability or mortality after acute ischemic stroke (AIS) in retrospective analyses, independent of mean blood pressure. The investigators' central hypothesis is that increased BPV is harmful after AIS and warrants reduction. However, prior BPV research in AIS patients has been retrospective and limited by non-standardized BP measurement and, therefore, BPV is not mentioned in current stroke guidelines. To address the limitations of prior BPV research, determine mechanisms of BPV's deleterious effect, and identify potentially effective methods to reduce BPV, the proposed study will: 1) prospectively validate that "short-term" and "long-term" BPV after AIS onset is associated w…
Where this study is enrolling (2)
- I'm interested
Yale-New Haven Hospital
New Haven, Connecticut
- I'm interested
University of Chicago Medical Center
Chicago, Illinois
Who can participate
Inclusion criteria
- ✓Ischemic stroke according to the American Heart Association (AHA) definition and either:
- ✓1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
- ✓2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
- ✓Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival
- ✓4\) NIH Stroke Scale ≥ 4 at time of enrollment
Exclusion criteria
- ✕Pre-morbid mRS ≥3
- ✕Predicted hospital system admission \<72 hours
- ✕Pacemaker or other MRI contraindications per American College of Radiology guidelines
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Trial data sourced from ClinicalTrials.gov.