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Early Phase 1Recruiting

Cardiac Power Output in Cardiogenic Shock Patients

Sponsored by University of Chicago

About this study

The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.

This study is designed as a prospective, observational, crossover study to assess the feasibility of using differences in invasive hemodynamics of cardiac function, representing myocardial reserve, to predict clinical outcomes for heart failure patients. Patients with heart failure referred for right heart catheterization (RHC) by the advanced heart failure team as part of 1) evaluation for advanced heart failure therapies, including left ventricular assist device (LVAD), orthotopic heart transplant (OHT), temporary or long-term inotrope therapy, or counter-pulsation (temporary intra-aortic balloon pump (IABP) or long-term with NuPulse device), 2) for accurate assessment of invasive hemodynamics due to worsening clinical status, 3) assessment of myocardial recovery for consideration of LVA…

Where this study is enrolling

Who can participate

Inclusion criteria

  • ✓1. LVEF ≤ 40%
  • ✓2. Referred for RHC for:
  • ✓1. Evaluation for advanced heart failure therapies, including LVAD, OHT, temporary or long-term inotrope therapy, or counter-pulsation (temporary or long-term with NuPulse device OR
  • ✓2. Accurate assessment of invasive hemodynamics due to worsening clinical status, OR
  • ✓3. Assessment of myocardial recovery for consideration of LVAD or counter-pulsation (temporary IABP or long-term with NuPulse device) decommissioning or removal OR
  • ✓4. Assessment of cardiac function and valvular abnormalities prior to planned valvular surgery for MR or AI
  • ✓3. Estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1.73 m2
  • ✓4. Age ≥ 18 years-old
  • ✓5. Intent for admission based on RHC data

Exclusion criteria

  • ✕1. eGFR \< 30 ml/min/1.73 m2
  • ✕2. Severe, non-revascularized coronary artery disease
  • ✕3. Concurrent acute coronary syndrome
  • ✕4. Age \< 18 years-old
  • ✕5. History of significant ventricular arrhythmia without an ICD

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Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.