Circadian Mechanisms, Glucose, and CV Risks in T1D
Sponsored by University of Illinois at Chicago
About this study
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.
People with type 1 diabetes (T1D) are disproportionately affected by cardiovascular disease (CVD). CVD is a leading cause of death in T1D, contributing to 40% of mortality. Sleep is recognized by both the American Heart Association and the American Diabetes Association as a critical health behavior to maintain glycemic control and reduce CVD risk. Short and/or irregular sleep have been associated with reduced glycemic control and non-dipping blood pressure in T1D, both of which are predictors of CV events. Emerging data suggest that behavioral sleep interventions targeting short or irregular sleep led to improved glycemic parameters. However, little is known about the mechanism by which improving sleep duration and/or regularity improves glycemic control and reduces CV risk in T1D. The inv…
Where this study is enrolling
- I'm interested
University of Illinois Chicago
Chicago, Illinois
Who can participate
Inclusion criteria
- ✓Adults 18-50 years with a clinical diagnosis of T1D for at least one year
- ✓Report habitual sleep irregularity ≥1 hour/week
- ✓Desire to improve sleep, and own a smartphone (Android or iPhone)
Exclusion criteria
- ✕Self-reported A1C within the past 6 months ≥10%
- ✕insomnia symptoms defined as Insomnia Severity Index score ≥15
- ✕history of restless leg syndrome
- ✕history of severe hypoglycemia (defined as hypoglycemic episode that results in loss of consciousness, seizure, or requiring emergency room visit or hospitalization) within the past 6 months
- ✕rotating shift or night work or routinely sleeping after 3 AM.
- ✕use of sleep medications/aids, significant medical comorbidities (such as heart failure, cirrhosis, chronic obstructive pulmonary disease requiring oxygen, active treatment for cancer, on renal replacement therapy \[dialysis\])
- ✕depression (Patient Health Questionnaire 8 \[PHQ-8\] score ≥15)
- ✕history of stroke with neurological deficits
- ✕pregnant, breast feeding, or planning pregnancy, as sleep and glucose are known to change during pregnancy and breastfeeding.
- ✕Allergy to lidocaine Participants who passed the first screen by phone will be scheduled for a consenting visit at UIC
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Trial data sourced from ClinicalTrials.gov.