Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Sponsored by Carl Allen
About this study
This is a research study of a drug called cobimetinib in children and adults diagnosed with Langerhans cell histiocytosis (LCH), and other histiocytic disorders that has returned or does not respond to treatment. Cobimetinib blocks activation of a protein called Mitogen-activated protein kinase (MEK) that is part of incorrect growth signals in histiocytosis cells. Four different groups of patients will be enrolled.
Enrolling at this location
Arkansas Children's Hospital
Little Rock, Arkansas
I'm interestedThis study also enrolls at 11 other locations. See all.
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Trial data sourced from ClinicalTrials.gov.