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Phase 2Recruiting

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

Sponsored by SWOG Cancer Research Network

About this study

This phase II Lung-MAP treatment trial test the combination of targeted drugs (capmatinib, osimertinib, and/or ramucirumab) in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and that has EGFR and MET gene changes. Capmatinib and osimertinib are in a class of medications called kinase inhibitors. They work by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Giving capmatinib, osimertinib, and/or ramucirumab and targeting abnormal gene changes in tumor cells may be effective in shrinking or stabilizing advanced non-small cell lung cancer.

PRIMARY OBJECTIVE: I. To compare investigator-assessed progression-free survival (IA-PFS) between participants with EGFR mutated, MET amplified non-small cell lung cancer (NSCLC) randomized to INC280 (capmatinib) and osimertinib with or without ramucirumab. SECONDARY OBJECTIVES: I. To evaluate if the combination of INC280 (capmatinib), osimertinib and ramucirumab or INC280 (capmatinib) and osimertinib during the first cycle of treatment has an acceptable toxicity rate. II. To evaluate the frequency and severity of toxicities within the arms. III. To compare IA-PFS between the arms, in the subset of participants with centrally-confirmed MET amplification in tissue. IV. To compare IA-PFS between the arms, in the subset of participants with centrally-confirmed MET amplification based on …

Where this study is enrolling (372)

  • Mobile Infirmary Medical Center

    Mobile, Alabama

    Call 251-435-3942

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  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis

    Daphne, Alabama

    I'm interested

  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland

    Saraland, Alabama

    I'm interested

  • Thomas Hospital

    Fairhope, Alabama

    Call 251-435-4584

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  • Katmai Oncology Group

    Anchorage, Alaska

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  • Kingman Regional Medical Center

    Kingman, Arizona

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  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas

    Call 501-686-8274

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  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas

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  • Kaiser Permanente San Leandro

    San Leandro, California

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    San Jose, California

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  • Veterans Affairs Medical Center - San Francisco

    San Francisco, California

    Call 415-221-4810

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  • Kaiser Permanente-San Francisco

    San Francisco, California

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  • California Pacific Medical Center-Pacific Campus

    San Francisco, California

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  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California

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  • Tower Cancer Research Foundation

    Beverly Hills, California

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  • Palo Alto Medical Foundation-Fremont

    Fremont, California

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    Fresno, California

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    La Jolla, California

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  • Loma Linda University Medical Center

    Loma Linda, California

    Call 909-558-4050

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  • Cedars-Sinai Medical Center

    Los Angeles, California

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    Modesto, California

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    Oakland, California

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    Roseville, California

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    Sacramento, California

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    Sacramento, California

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  • University of California Davis Comprehensive Cancer Center

    Sacramento, California

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    Vallejo, California

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    Vallejo, California

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    Roseville, California

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    Arroyo Grande, California

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    Auburn, California

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    Torrance, California

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    Walnut Creek, California

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    Sunnyvale, California

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    South San Francisco, California

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    Santa Rosa, California

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    Santa Cruz, California

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    Santa Clara, California

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  • Kaiser San Rafael-Gallinas

    San Rafael, California

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  • Mills Health Center

    San Mateo, California

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  • UCHealth University of Colorado Hospital

    Aurora, Colorado

    Call 720-848-0650

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  • Medical Center of the Rockies

    Loveland, Colorado

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  • UCHealth Lone Tree Health Center

    Lone Tree, Colorado

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    Greeley, Colorado

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  • Poudre Valley Hospital

    Fort Collins, Colorado

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  • Memorial Hospital North

    Colorado Springs, Colorado

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  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado

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  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado

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    Glastonbury, Connecticut

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    Greenwich, Connecticut

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    Guilford, Connecticut

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    Hartford, Connecticut

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  • Yale University

    New Haven, Connecticut

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    North Haven, Connecticut

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  • Smilow Cancer Hospital-Orange Care Center

    Orange, Connecticut

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    Stamford, Connecticut

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    Torrington, Connecticut

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    Trumbull, Connecticut

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    Waterbury, Connecticut

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    Waterford, Connecticut

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    Derby, Connecticut

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    Fairfield, Connecticut

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  • Bayhealth Hospital Kent Campus

    Dover, Delaware

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    Milford, Delaware

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    Washington D.C., District of Columbia

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    Hollywood, Florida

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    Pembroke Pines, Florida

    Call 954-265-4325

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  • Moffitt Cancer Center

    Tampa, Florida

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  • Northside Hospital - Duluth

    Duluth, Georgia

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  • Northeast Georgia Medical Center-Gainesville

    Gainesville, Georgia

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    Athens, Georgia

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    Lawrenceville, Georgia

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  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

    Savannah, Georgia

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    Atlanta, Georgia

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  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii

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  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii

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  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii

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    Honolulu, Hawaii

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  • Queen's Medical Center

    Honolulu, Hawaii

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  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho

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  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho

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    Sandpoint, Idaho

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  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho

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    Caldwell, Idaho

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    Nampa, Idaho

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  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois

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  • Northwestern Medicine Orland Park

    Orland Park, Illinois

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  • Illinois CancerCare-Bloomington

    Bloomington, Illinois

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  • Illinois CancerCare-Canton

    Canton, Illinois

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  • Illinois CancerCare-Carthage

    Carthage, Illinois

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  • Centralia Oncology Clinic

    Centralia, Illinois

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  • Rush MD Anderson Cancer Center

    Chicago, Illinois

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  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois

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  • Carle at The Riverfront

    Danville, Illinois

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  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois

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  • Decatur Memorial Hospital

    Decatur, Illinois

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  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois

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  • Illinois CancerCare-Dixon

    Dixon, Illinois

    Call 815-285-7800

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  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois

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  • Carle Physician Group-Effingham

    Effingham, Illinois

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  • Crossroads Cancer Center

    Effingham, Illinois

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  • Advocate Sherman Hospital

    Elgin, Illinois

    Call 847-429-2907

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  • Illinois CancerCare-Eureka

    Eureka, Illinois

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  • Illinois CancerCare-Galesburg

    Galesburg, Illinois

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  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois

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  • Northwestern Medicine Glenview Outpatient Center

    Glenview, Illinois

    Call 312-695-1102

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  • Advocate South Suburban Hospital

    Hazel Crest, Illinois

    Call 708-799-9995

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  • Edward Hines Jr VA Hospital

    Hines, Illinois

    Call 708-202-8387

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  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois

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  • AMG Libertyville - Oncology

    Libertyville, Illinois

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  • Condell Memorial Hospital

    Libertyville, Illinois

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  • Illinois CancerCare-Macomb

    Macomb, Illinois

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  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois

    I'm interested

  • Loyola University Medical Center

    Maywood, Illinois

    Call 708-226-4357

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  • Northwestern Medicine Oak Brook

    Oak Brook, Illinois

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  • Advocate Christ Medical Center

    Oak Lawn, Illinois

    Call 800-323-8622

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  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois

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  • Advocate Lutheran General Hospital

    Park Ridge, Illinois

    Call 847-384-3621

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  • Illinois CancerCare-Pekin

    Pekin, Illinois

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  • Illinois CancerCare-Peoria

    Peoria, Illinois

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  • Illinois CancerCare-Peru

    Peru, Illinois

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  • Illinois CancerCare-Princeton

    Princeton, Illinois

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  • OSF Saint Anthony Medical Center

    Rockford, Illinois

    Call 815-227-2633

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  • Southern Illinois University School of Medicine

    Springfield, Illinois

    Call 217-545-7929

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  • Springfield Clinic

    Springfield, Illinois

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  • Springfield Memorial Hospital

    Springfield, Illinois

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  • Carle Cancer Center

    Urbana, Illinois

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  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois

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  • Illinois CancerCare - Washington

    Washington, Illinois

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  • Advocate Good Shepherd Hospital

    Barrington, Illinois

    Call 847-842-4847

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  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois

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  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois

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  • Northwestern University

    Chicago, Illinois

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  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois

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  • Rush MD Anderson Cancer Center at Rush Oak Park

    Oak Park, Illinois

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  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa

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  • Iowa Methodist Medical Center

    Des Moines, Iowa

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  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa

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  • Mercy Medical Center - Des Moines

    Des Moines, Iowa

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  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa

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  • HaysMed

    Hays, Kansas

    Call 785-623-5774

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  • Lawrence Memorial Hospital

    Lawrence, Kansas

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  • The University of Kansas Cancer Center - Olathe

    Olathe, Kansas

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  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas

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  • University of Kansas Hospital-Indian Creek Campus

    Overland Park, Kansas

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  • Salina Regional Health Center

    Salina, Kansas

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  • University of Kansas Health System Saint Francis Campus

    Topeka, Kansas

    Call 785-295-8000

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  • University of Kansas Cancer Center

    Kansas City, Kansas

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  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas

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  • University of Kansas Clinical Research Center

    Fairway, Kansas

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  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky

    Call 859-257-3379

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  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine

    Call 800-987-3005

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  • Kaiser Permanente-Gaithersburg Medical Center

    Gaithersburg, Maryland

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    Baltimore, Maryland

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    Largo, Maryland

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    Cumberland, Maryland

    Call 240-964-1400

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  • Kaiser Permanente Lutherville - Timonium Medical Center

    Lutherville, Maryland

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    Worcester, Massachusetts

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    Springfield, Massachusetts

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    Detroit, Michigan

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  • Hurley Medical Center

    Flint, Michigan

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  • Genesys Hurley Cancer Institute

    Flint, Michigan

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    Flint, Michigan

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  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan

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    Dearborn, Michigan

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  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan

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    Chelsea, Michigan

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    Canton, Michigan

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    Canton, Michigan

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    Brighton, Michigan

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    Brighton, Michigan

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  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan

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    Ypsilanti, Michigan

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    Ypsilanti, Michigan

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    Wyandotte, Michigan

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    West Bloomfield, Michigan

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    Tawas City, Michigan

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    Saginaw, Michigan

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    Pontiac, Michigan

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    Novi, Michigan

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    Livonia, Michigan

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  • Essentia Health - Deer River Clinic

    Deer River, Minnesota

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  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota

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    Saint Paul, Minnesota

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  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota

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    Minneapolis, Minnesota

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  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota

    Call 218-786-3308

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  • Fairview Southdale Hospital

    Edina, Minnesota

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    Duluth, Minnesota

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    Coon Rapids, Minnesota

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    Waconia, Minnesota

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    Virginia, Minnesota

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    Sandstone, Minnesota

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    Saint Paul, Minnesota

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  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi

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    Grenada, Mississippi

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  • Baptist Memorial Hospital and Cancer Center-Union County

    New Albany, Mississippi

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  • University of Mississippi Medical Center

    Jackson, Mississippi

    Call 601-815-6700

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  • Baptist Memorial Hospital and Cancer Center-Oxford

    Oxford, Mississippi

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    Southhaven, Mississippi

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  • Saint Francis Medical Center

    Cape Girardeau, Missouri

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  • BJC Outpatient Center at Sunset Hills

    Sunset Hills, Missouri

    Call 314-996-5569

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  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri

    Call 314-996-5569

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  • Mercy Hospital Saint Louis

    St Louis, Missouri

    Call 314-251-7066

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  • Missouri Baptist Medical Center

    St Louis, Missouri

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  • Mercy Hospital South

    St Louis, Missouri

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  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri

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  • University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri

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  • University of Kansas Cancer Center - North

    Kansas City, Missouri

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  • University of Kansas Cancer Center - Briarcliff

    Kansas City, Missouri

    Call 913-588-3671

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  • University Health Truman Medical Center

    Kansas City, Missouri

    Call 816-404-4375

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  • Parkland Health Center - Farmington

    Farmington, Missouri

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  • Community Medical Center

    Missoula, Montana

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  • Benefis Sletten Cancer Institute

    Great Falls, Montana

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  • Community Hospital of Anaconda

    Anaconda, Montana

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  • Billings Clinic Cancer Center

    Billings, Montana

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  • Bozeman Health Deaconess Hospital

    Bozeman, Montana

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  • Logan Health Medical Center

    Kalispell, Montana

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  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada

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    Las Vegas, Nevada

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  • Solinsky Center for Cancer Care

    Manchester, New Hampshire

    Call 800-339-6484

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  • New Hampshire Oncology Hematology PA-Concord

    Concord, New Hampshire

    Call 603-224-2556

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  • Virtua Samson Cancer Center

    Moorestown, New Jersey

    I'm interested

  • Virtua Voorhees

    Voorhees Township, New Jersey

    I'm interested

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico

    I'm interested

  • James J Peters VA Medical Center

    The Bronx, New York

    I'm interested

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York

    I'm interested

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York

    I'm interested

  • University of Rochester

    Rochester, New York

    Call 585-275-5830

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  • Durham VA Medical Center

    Durham, North Carolina

    I'm interested

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota

    I'm interested

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota

    I'm interested

  • Sanford Broadway Medical Center

    Fargo, North Dakota

    I'm interested

  • Mercy Health - Saint Anne Hospital

    Toledo, Ohio

    I'm interested

  • Miami Valley Hospital

    Dayton, Ohio

    I'm interested

  • Mount Carmel Grove City Hospital

    Grove City, Ohio

    I'm interested

  • Mount Carmel East Hospital

    Columbus, Ohio

    I'm interested

  • Miami Valley Hospital South

    Centerville, Ohio

    I'm interested

  • Aultman Health Foundation

    Canton, Ohio

    I'm interested

  • Cleveland Clinic Mercy Hospital

    Canton, Ohio

    Call 888-293-4673

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  • Strecker Cancer Center-Belpre

    Belpre, Ohio

    I'm interested

  • The Mark H Zangmeister Center

    Columbus, Ohio

    I'm interested

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio

    I'm interested

  • Springfield Regional Cancer Center

    Springfield, Ohio

    I'm interested

  • Trinity's Tony Teramana Cancer Center

    Steubenville, Ohio

    Call 888-874-7000

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  • ProMedica Flower Hospital

    Sylvania, Ohio

    I'm interested

  • Premier Blood and Cancer Center

    Dayton, Ohio

    Call 937-276-8320

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  • Upper Valley Medical Center

    Troy, Ohio

    I'm interested

  • Saint Ann's Hospital

    Westerville, Ohio

    I'm interested

  • Genesis Healthcare System Cancer Care Center

    Zanesville, Ohio

    I'm interested

  • Adena Regional Medical Center

    Chillicothe, Ohio

    I'm interested

  • Southern Ohio Medical Center

    Portsmouth, Ohio

    I'm interested

  • Mercy Health - Perrysburg Hospital

    Perrysburg, Ohio

    I'm interested

  • Licking Memorial Hospital

    Newark, Ohio

    I'm interested

  • Knox Community Hospital

    Mount Vernon, Ohio

    I'm interested

  • Memorial Hospital

    Marysville, Ohio

    I'm interested

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio

    Call 937-569-7515

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  • Miami Valley Hospital North

    Dayton, Ohio

    I'm interested

  • Cancer Centers of Southwest Oklahoma Research

    Lawton, Oklahoma

    Call 877-231-4440

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  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma

    I'm interested

  • Kaiser Permanente Northwest

    Portland, Oregon

    I'm interested

  • Oregon Health and Science University

    Portland, Oregon

    I'm interested

  • Providence Portland Medical Center

    Portland, Oregon

    I'm interested

  • Providence Newberg Medical Center

    Newberg, Oregon

    I'm interested

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon

    I'm interested

  • Providence Willamette Falls Medical Center

    Oregon City, Oregon

    I'm interested

  • Providence Saint Vincent Medical Center

    Portland, Oregon

    I'm interested

  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

    Mechanicsburg, Pennsylvania

    I'm interested

  • UPMC-Saint Margaret

    Pittsburgh, Pennsylvania

    Call 412-784-4900

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  • Arnold Palmer Cancer Center Medical Oncology Norwin

    North Huntingdon, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center - New Castle

    New Castle, Pennsylvania

    I'm interested

  • UPMC Cancer Center-Natrona Heights

    Natrona Heights, Pennsylvania

    Call 724-230-3030

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  • UPMC Hillman Cancer Center - Part of Frick Hospital

    Mount Pleasant, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center in Coraopolis

    Moon Township, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center - Monroeville

    Monroeville, Pennsylvania

    I'm interested

  • UPMC Cancer Center at UPMC McKeesport

    McKeesport, Pennsylvania

    Call 412-647-8073

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  • Geisinger Medical Oncology-Lewisburg

    Lewisburg, Pennsylvania

    I'm interested

  • Sechler Family Cancer Center

    Lebanon, Pennsylvania

    I'm interested

  • UPMC-Johnstown/John P. Murtha Regional Cancer Center

    Johnstown, Pennsylvania

    Call 814-534-4724

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  • IRMC Cancer Center

    Indiana, Pennsylvania

    I'm interested

  • Adams Cancer Center

    Gettysburg, Pennsylvania

    Call 877-441-7957

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  • UPMC Cancer Center at UPMC Horizon

    Farrell, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center Erie

    Erie, Pennsylvania

    I'm interested

  • Ephrata Cancer Center

    Ephrata, Pennsylvania

    Call 717-721-4840

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  • Geisinger Cancer Center Dickson City

    Dickson City, Pennsylvania

    I'm interested

  • UPMC-Heritage Valley Health System Beaver

    Beaver, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center - Passavant - Cranberry

    Cranberry Township, Pennsylvania

    I'm interested

  • WellSpan Medical Oncology and Hematology

    Chambersburg, Pennsylvania

    Call 717-217-6020

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  • Carlisle Regional Cancer Center

    Carlisle, Pennsylvania

    I'm interested

  • UPMC Altoona

    Altoona, Pennsylvania

    I'm interested

  • UPMC Pinnacle Cancer Center/Community Osteopathic Campus

    Harrisburg, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center at Butler Health System

    Butler, Pennsylvania

    I'm interested

  • Geisinger Medical Center

    Danville, Pennsylvania

    I'm interested

  • UPMC Cancer Centers - Arnold Palmer Pavilion

    Greensburg, Pennsylvania

    Call 724-838-1900

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  • UPMC-Mercy Hospital

    Pittsburgh, Pennsylvania

    Call 800-533-8762

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  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania

    Call 412-647-8073

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  • UPMC-Passavant Hospital

    Pittsburgh, Pennsylvania

    Call 412-367-6454

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  • UPMC-Saint Clair Hospital Cancer Center

    Pittsburgh, Pennsylvania

    Call 412-502-3920

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  • Community Medical Center

    Scranton, Pennsylvania

    I'm interested

  • UPMC Cancer Center at UPMC Northwest

    Seneca, Pennsylvania

    Call 814-676-7900

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  • UPMC Cancer Center-Uniontown

    Uniontown, Pennsylvania

    I'm interested

  • UPMC Cancer Center-Washington

    Washington, Pennsylvania

    I'm interested

  • UPMC West Mifflin-Cancer Center Jefferson

    West Mifflin, Pennsylvania

    Call 412-653-8100

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  • Geisinger Wyoming Valley/Henry Cancer Center

    Wilkes-Barre, Pennsylvania

    I'm interested

  • Divine Providence Hospital

    Williamsport, Pennsylvania

    I'm interested

  • WellSpan Health-York Cancer Center

    York, Pennsylvania

    Call 877-441-7957

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  • UPMC Memorial

    York, Pennsylvania

    Call 717-724-6760

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  • Smilow Cancer Hospital Care Center - Westerly

    Westerly, Rhode Island

    I'm interested

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina

    I'm interested

  • Prisma Health Greenville Memorial Hospital

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina

    I'm interested

  • Medical University of South Carolina

    Charleston, South Carolina

    I'm interested

  • AnMed Health Cancer Center

    Anderson, South Carolina

    I'm interested

  • Saint Joseph's/Candler - Bluffton Campus

    Bluffton, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina

    I'm interested

  • Ralph H Johnson VA Medical Center

    Charleston, South Carolina

    I'm interested

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota

    I'm interested

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee

    I'm interested

  • The Don and Sybil Harrington Cancer Center

    Amarillo, Texas

    I'm interested

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah

    I'm interested

  • University of Vermont Medical Center

    Burlington, Vermont

    I'm interested

  • Central Vermont Medical Center/National Life Cancer Treatment

    Berlin Corners, Vermont

    Call 802-225-5400

    This research site can be reached directly by phone. Call to ask about this study.

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  • University of Vermont and State Agricultural College

    Burlington, Vermont

    I'm interested

  • Kaiser Permanente-Caton Hill Medical Center

    Woodbridge, Virginia

    I'm interested

  • Kaiser Permanente Tysons Corner Medical Center

    McLean, Virginia

    I'm interested

  • University of Virginia Cancer Center

    Charlottesville, Virginia

    I'm interested

  • Valley Medical Center

    Renton, Washington

    I'm interested

  • FHCC at EvergreenHealth

    Kirkland, Washington

    Call 425-899-6000

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  • Swedish Medical Center-First Hill

    Seattle, Washington

    I'm interested

  • FHCC at Northwest Hospital

    Seattle, Washington

    Call 206-606-5800

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  • University of Washington Medical Center - Montlake

    Seattle, Washington

    Call 800-804-8824

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  • FHCC Overlake

    Bellevue, Washington

    Call 425-454-2148

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  • Fred Hutchinson Cancer Center

    Seattle, Washington

    Call 800-804-8824

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  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia

    I'm interested

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin

    I'm interested

  • Aspirus Cancer Care - James Beck Cancer Center

    Rhinelander, Wisconsin

    I'm interested

  • Aurora Cancer Care-Racine

    Racine, Wisconsin

    I'm interested

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin

    I'm interested

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin

    I'm interested

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin

    I'm interested

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin

    I'm interested

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin

    I'm interested

  • Aspirus Medford Hospital

    Medford, Wisconsin

    I'm interested

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin

    I'm interested

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin

    I'm interested

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin

    I'm interested

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin

    I'm interested

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin

    I'm interested

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin

    I'm interested

  • Langlade Hospital and Cancer Center

    Antigo, Wisconsin

    I'm interested

  • Duluth Clinic Ashland

    Ashland, Wisconsin

    I'm interested

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin

    I'm interested

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin

    I'm interested

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin

    I'm interested

  • Aspirus Cancer Care - Wisconsin Rapids

    Wisconsin Rapids, Wisconsin

    Call 715-422-7718

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  • Marshfield Medical Center - Weston

    Weston, Wisconsin

    I'm interested

  • Aurora West Allis Medical Center

    West Allis, Wisconsin

    I'm interested

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin

    I'm interested

  • Aspirus Regional Cancer Center

    Wausau, Wisconsin

    Call 877-405-6866

    This research site can be reached directly by phone. Call to ask about this study.

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  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin

    I'm interested

  • Aurora Medical Center in Summit

    Summit, Wisconsin

    I'm interested

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin

    I'm interested

  • Aspirus Cancer Care - Stevens Point

    Stevens Point, Wisconsin

    I'm interested

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin

    I'm interested
Who can participate

Inclusion criteria

  • ✓Patients must meet all SCREENING/PRE-SCREENING and SUB-STUDY REGISTRATION COMMON ELIGIBILITY CRITERIA as specified in S1400: Phase II/III Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)
  • ✓Participants must have been assigned to S1900G by the Southwest Oncology Group (SWOG) Statistics and Data Management Center (SDMC). Assignment to S1900G is determined by the LUNGMAP protocol
  • ✓Participants must have documentation of NSCLC with a sensitizing EGFR mutation and have radiologically or clinically progressed (in the opinion of the treating physician) on osimertinib, alone or in combination with other agent(s), as their most recent line of therapy. Any number of prior lines of therapy is allowed
  • ✓Participants must have a MET amplification determined by tissue-based or blood-based (circulating tumor DNA \[ctDNA\]) next generation sequencing (NGS) assay. MET amplifications may have been determined based on tissue submitted for testing by Foundation Medicine Inc (FMI) through the LUNGMAP screening protocol or using test results completed outside of the study. Tissue or blood must be obtained after disease progression on osimertinib (alone or in combination with another agent\[s\]). The testing must be done within a laboratory with Clinical Laboratory Improvement Act (CLIA), International Organization for Standardization (ISO)/Independent Ethics Committee (IEC), College of American Pathologists (CAP), or similar certification
  • ✓Note: Participants previously tested for and determined to have MET amplified NSCLC, at the time of progression on osimertinib, outside of LUNGMAP, must also submit tissue for central FMI testing on the LUNGMAP screening protocol, if available
  • ✓Participants must have either measurable disease or non-measurable disease documented by CT or MRI. The CT from a combined PET/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to sub-study randomization. Non-measurable disease must be assessed within 42 days prior to sub-study randomization. All known sites of disease must be assessed and documented on the Baseline Tumor Assessment Form. Participants whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to sub-study randomization to be considered measurable
  • ✓Participants must have a CT with contrast or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to sub-study randomization
  • ✓Participants with symptomatic CNS metastasis (brain metastases or leptomeningeal disease) must be neurologically stable and have a stable or decreasing corticosteroid requirement for at least 5 days before sub-study randomization
  • ✓Participants must have recovered (=\< grade 1) from any side effects of prior therapy, except for alopecia and vitiligo
  • ✓Participants must be able to swallow tablets whole
  • ✓Absolute neutrophil count \>= 1.5 x 10\^3/uL (within 28 days prior to sub-study randomization)
  • ✓Hemoglobin \< 9.0 g/dL (within 28 days prior to sub-study randomization)
  • ✓Platelets \>= 100 x 10\^3/uL (within 28 days prior to sub-study randomization)
  • ✓Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) unless history of Gilbert's disease (within 28 days prior to sub-study randomization). Participants with history of Gilbert's disease must have total bilirubin =\< 5 x institutional ULN
  • ✓Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x institutional ULN. Participants with history of liver metastasis must have AST =\< 5 x ULN (within 28 days prior to sub-study randomization)
  • ✓Participants must have a serum creatinine =\< the IULN OR calculated creatinine clearance \>= 50 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 28 days prior to sub-study randomization
  • ✓Participants' most recent Zubrod performance status must be 0-1 and be documented within 28 days prior to sub-study randomization
  • ✓Participants must have an electrocardiogram (ECG) performed, with a Fridericia's Correction Formula (QTcF) =\< 470 msec, within 28 days prior to sub-study randomization. It is suggested that a local cardiologist review the QTcF intervals
  • ✓Participants must have a completed medical history and physical exam within 28 days prior to sub-study randomization
  • ✓Participants must have a urinalysis performed 28 days prior to sub-study randomization. Participant must have a urinary protein =\< 1+ on dipstick or routine urinalysis (UA). Random analysis of urine protein with a normal value is sufficient. If urine dipstick or routine analysis indicated proteinuria \>= 2+, then a 24-hour urine is to be collected and demonstrate \< 2000 mg of protein in 24 hours to allow participation in the study
  • ✓Participants must have an International Normalized Ratio (INR) =\< 1.5 seconds above the institutional upper limit of normal (IULN) (unless receiving anticoagulation therapy) documented within 28 days to sub-study randomization. Participants must have a partial thromboplastin time (PTT) =\< 5 seconds above the 'institutional upper limit of normal (IULN) (unless receiving anticoagulation therapy) documented within 28 days prior to sub-study randomization
  • ✓Participants with known human immunodeficiency virus (HIV) infection must be on effective anti-retroviral therapy at randomization and have undetectable viral load within 6 months prior to sub-study randomization
  • ✓Participants must have asymptomatic serum amylase =\< 2 x ULN and serum lipase =\< ULN obtained within 28 days prior to sub-study randomization. Asymptomatic is defined as having no signs and/ or symptoms suggesting pancreatitis or pancreatic injury (e.g. elevated P. amylase, abnormal imaging findings of pancreas, etc.)
  • ✓Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better
  • ✓Participants must agree to have blood specimens submitted for circulating tumor DNA (ctDNA)
  • ✓Participants must also be offered participation in specimen banking. With participant consent, specimens must be collected and submitted via the SWOG Specimen Tracking System
  • ✓Note: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
  • ✓Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines
  • ✓Participants with impaired decision-making capacity must not have a neurological or psychological condition that precludes their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator). For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations

Exclusion criteria

  • ✕Participants must not have received an anti-VEGF or VEGFR inhibitor or MET inhibitor
  • ✕Participants must not have received any anti-cancer drug (investigational or standard of care drug, except osimertinib) within 21 days prior to sub-study randomization
  • ✕Note: osimertinib may continue up to the day prior to study treatment initiation
  • ✕Participants must not have received any radiation therapy within 14 days prior to sub-study randomization
  • ✕Participants must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment while receiving treatment on this study
  • ✕Participants must not have had a major surgery within 14 days prior to sub-study randomization. Participants must have fully recovered from the effects of prior surgery in the opinion of the treating investigator
  • ✕Participants must not have received a live attenuated vaccination within 28 days prior to sub-study randomization. All COVID-19 vaccines that have received Food and Drug Administration (FDA) approval or FDA emergency use authorization are acceptable
  • ✕Participants must not have received strong inducers of CYP3A4 (including herbal supplements such as St. John's Wort); CYP3A4 inhibitors; CYP1A2 substrates; P-gp and BCRP substrates; sensitive substrates of MATE1 and MATE2K; or drugs that are known to prolong QT interval within 7 days prior to sub-study registration and must not be planning to use any of these throughout protocol treatment
  • ✕Participants must not have uncontrolled blood pressure and hypertension within 28 days prior to sub-study randomization
  • ✕Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen
  • ✕Participants must not be pregnant or breastfeeding (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped). Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.