DNA Methylation and Vascular Function
Sponsored by University of Illinois at Chicago
About this study
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.
The long-term goal of this study is to identify valid targets and strategies for the prevention and treatment of obesity-related cardiovascular disease. Obesity is characterized by a large accumulation of fat tissues that secrete numerous inflammatory mediators (called adipocytokines), generating a systemic inflammatory state. These adipocytokines induce vascular dysfunction which is the initial step towards developing cardiovascular disease. Obesity is affected by environmental factors such as diet and physical activity. These factors induce epigenetic changes, which are changes that affect gene expression without altering the DNA sequence. One of these epigenetic modifications is the reduction in DNA methylation (referred to as hypomethylation) resulting in subsequent increases in gene e…
Where this study is enrolling
- I'm interested
University of Illinois at Chicago
Chicago, Illinois
Who can participate
Inclusion criteria
- ✓BMI ≥ 35 kg/m2
- ✓Between ages 18-50 years
- ✓Not pregnant
- ✓Approved for a bariatric surgery
Exclusion criteria
- ✕To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
- ✕Pregnant women will be excluded, as they will not be eligible for bariatric surgery
- ✕Current smokers
- ✕Currently abusing alcohol or drugs
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Trial data sourced from ClinicalTrials.gov.