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Phase 3Recruiting

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Sponsored by Eli Lilly and Company

About this study

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Where this study is enrolling (33)

  • AMR Clinical

    Mobile, Alabama

    Call 251-414-1984

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  • Elite Clinical Studies, LLC

    Phoenix, Arizona

    I'm interested

  • Tucson Orthopaedic Institute - North Wyatt Drive

    Tucson, Arizona

    I'm interested

  • Care Access - 801 South Power Road, Mesa

    Mesa, Arizona

    Call 877-791-0656

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  • Wolverine Clinical Trials

    Santa Ana, California

    Call 714-617-2426

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Show all 33 locations

  • Ark Clinical Research - Fountain Valley

    Fountain Valley, California

    Call 714-988-2021

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  • Diablo Clinical Research, Inc.

    Walnut Creek, California

    Call 925-930-7267

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  • Encompass Clinical Research

    Spring Valley, California

    Call 619-660-9068

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  • Conquest Research

    Winter Park, Florida

    Call 407-916-0060

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  • Care Access - St. Petersburg

    St. Petersburg, Florida

    Call 877-791-0656

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  • Westside Center for Clinical Research

    Jacksonville, Florida

    Call 904-693-1490

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  • Orita Clinical Research

    Decatur, Georgia

    I'm interested

  • Medical Research Partners

    Ammon, Idaho

    Call 208-681-9070

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  • Great Lakes Clinical Trials - Ravenswood

    Chicago, Illinois

    I'm interested

  • Qualmedica Research, LLC

    Evansville, Indiana

    Call 812-205-2475

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  • AMR Clinical

    Newton, Kansas

    Call 316-804-7304

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  • Monroe Biomedical Research - Louisville

    Louisville, Kentucky

    Call 502-515-5672

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  • Skylight Health Research - Burlington

    Burlington, Massachusetts

    Call 781-653-4281

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  • Care Access - Quincy

    Quincy, Massachusetts

    Call 877-791-0656

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  • Rochester Clinical Research, LLC

    Rochester, New York

    Call 585-288-0890

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  • NYC Research INC

    Long Island City, New York

    Call 516-574-9232

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  • Ellipsis Research Group - Brooklyn - 7th Street

    Brooklyn, New York

    Call 347-422-0317

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  • Central States Research

    Tulsa, Oklahoma

    Call 918-645-5400

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  • Epic Medical Research - DeSoto

    DeSoto, Texas

    Call 197-277-7695

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  • Endeavor Clinical Trials

    San Antonio, Texas

    Call 518-428-6859

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  • Care Access - Houston

    Houston, Texas

    Call 617-843-2781

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  • JCCT - Juno Bellaire Site

    Bellaire, Texas

    Call 713-779-5494

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  • Valley Institute of Research - Fort Worth

    Fort Worth, Texas

    Call 817-625-7733

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  • VIP Trials

    San Antonio, Texas

    Call 210-569-2672

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  • Consano Clinical Research, LLC

    Shavano Park, Texas

    Call 210-545-4900

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  • Texas Valley Clinical Research

    Weslaco, Texas

    Call 956-431-8090

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  • Charlottesville Medical Research

    Charlottesville, Virginia

    Call 434-817-2442

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  • Paramount Clinical Research - Data Point Clinical Research

    Kirkland, Washington

    Call 425-577-1107

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Who can participate

Inclusion criteria

  • ✓Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
  • ✓Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
  • ✓Have tried at least once to lose weight through diet but were unsuccessful
  • ✓Have osteoarthritis of the knee and at least one of the following conditions:
  • ✓Be over 50 years old
  • ✓Have morning knee stiffness that lasts about 30 minutes
  • ✓Have a crackling or grinding sound or feeling in the knee

Exclusion criteria

  • ✕Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
  • ✕Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • ✕Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • ✕Have an active knee infection
  • ✕Have had within 90 days prior to screening:
  • ✕heart attack
  • ✕stroke
  • ✕coronary artery revascularization
  • ✕unstable angina, or
  • ✕hospitalization due to congestive heart failure
  • ✕Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • ✕Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.