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Genetic and Environmental Risk Factors for Hemorrhagic Stroke

Sponsored by State University of New York at Buffalo

About this study

The purpose of this study is to find risk factors for hemorrhagic stroke.

The proposed research builds on the most robust, statistically significant and replicated association identified to determine the mechanism by which it may relate to intracerebral hemorrhage (ICH) risk. Given that ICH is an extreme phenotype on a spectrum of manifestations of cerebral small vessel disease, the findings that emerge from our proposed studies offer the promise of broad impact for research and treatment in a wide variety of cerebrovascular disorders. In the genetic epidemiology of hemorrhagic stroke, we propose to perform an in-depth fine-mapping of the entire 1q22 genomic region (\~250kb) to investigate whether genetic variants influence gene expression that correlates with ICH status or changes in expression over time in ICH cases. As existing samples were not processed for…

Where this study is enrolling (7)

Show all 7 locations
Who can participate

Inclusion criteria

  • ✓Age 18 or older
  • ✓Resident (6 months or longer) within the recruitment center
  • ✓Fulfillment of the criteria for spontaneous ICH
  • ✓No evidence of trauma, brain tumor/metastases or infectious processes as a cause of the hemorrhage
  • ✓Ability of the patient or legal representative to provide consent for an interview, blood pressure determinations and DNA sampling

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.