GI Oxalate Absorption
Sponsored by University of Chicago
About this study
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.
The study will be carried out in the University of Chicago Medicine (UCM) Clinical Research Center (CRC). Study Population and Recruitment Enroll 10 post-Roux-en-Y Gastric Bypass stone forming, 10 obese stone forming, and 10 non-obese stone forming participants over four years of the award. Patients will be recruited at the University of Chicago Kidney Stone Clinic and Bariatric Surgery Clinics (both current and repository of previous patients). The Bariatric Surgery Clinic is a large clinic and Center for Excellence for bariatric surgery. The group's four active surgeons (including study advisor, Dr. John Alverdy) perform 300 bariatric surgeries per year. Over the past 10 years, at least one quarter to one half of these procedures have been Roux-en-Y Gastric Bypass. Incidence rates for s…
Where this study is enrolling
- I'm interested
University of Chicago Medical Center
Chicago, Illinois
Who can participate
Inclusion criteria
- ✓Post-Roux-en-Y gastric bypass stone formers:
- ✓Age 18-70
- ✓Previous history of Roux-en-Y gastric bypass
- ✓History of at least one calcium-based kidney stone after surgery
- ✓Pre-protocol urine oxalate above the lab normal range (50mg/day)
- ✓Obese stone formers:
- ✓Age 18-70
- ✓Body mass index (BMI) \>=30kg/m2
- ✓History of at least one calcium-based kidney stone
- ✓Pre-protocol urine oxalate above the lab normal range (50mg/day)
- ✓Non-obese stone formers:
- ✓Age 18-70, BMI between 18.5-29.9 kg/m2
- ✓History of at least one calcium-based kidney stone
Exclusion criteria
- ✕Post-Roux-en-Y gastric bypass stone formers:
- ✕History of colon resection (partial or complete)
- ✕History of duodenal switch bowel surgery
- ✕History of ileal-jejunal bypass surgery
- ✕History of primarily uric acid, cysteine, or struvite stones
- ✕Obese and non-obese stone formers:
- ✕History of bowel surgery
- ✕History of colon resection
- ✕History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis)
- ✕History of primarily uric acid, cysteine, or struvite stones
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Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.