Immune Function and the Progression to T1D
Sponsored by University of Florida
About this study
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.
Newly proposed studies will identify the inflammatory cues that draw immune cells into islets for disease initiation (Project 1); probe the motility of immune cells through inflamed vasculature to the target organ and antigen priming sites within secondary lymphatics (Project 2); and characterize the T1D-associated adaptive immune signatures in blood and immune tissues (Project 3). The overall hypothesis of the renewed P01 states: 1) the impact of T1D-risk variants will vary by tissue, cell subset, and activation state, and 2) risk variants, cellular stress, and defects in immunologic pathways are key to engender the autoimmune destruction of pancreatic B-cells that results in T1D.
Where this study is enrolling (3)
- I'm interested
Kieran McGrail
Gainesville, Florida
- I'm interested
The Ohio State University
Columbus, Ohio
- I'm interested
Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital
Houston, Texas
Who can participate
Inclusion criteria
- ✓able to have blood drawn -
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Trial data sourced from ClinicalTrials.gov.