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Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction

Sponsored by University of Houston

About this study

The purposes of this study include: 1. \- To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke. 2. \- To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.

Stroke is a leading cause of long-term disability in the United States. Of the more than 700,000 Americans who experience a stroke each year, two-thirds survive. 69% of patients who were admitted to a rehabilitation unit following stroke have mild to severe upper extremity dysfunction. Currently, there are more than seven million stroke survivors in the U.S., many of whom have long-term motor and sensory impairments, especially in the arm. The objective of this study involves both scientific and clinical aspects: For the first purpose, intermuscular coordination patterns emerging under isometric reaching and dynamic conditions will be identified to predict impairment of both non-motion or motion-involved task performance and severity of motor impairment after stroke. This aim will enroll …

Where this study is enrolling

Who can participate

Inclusion criteria

  • ✓for aged matched healthy group
  • ✓Male or female whose age range between 40 and 75
  • ✓no known neurological injuries

Exclusion criteria

  • ✕for aged matched healthy group
  • ✕have an orthopedic disorder involving upper limbs;
  • ✕have a history of any neurologic disease;
  • ✕have any history of epilepsy of the potential participants and/or their family members;
  • ✕are unable to consent;
  • ✕are pregnant.
  • ✕Inclusion criteria for stroke group
  • ✕male or female hemiparetic chronic stroke survivors;
  • ✕age ranging between 40-75 year;
  • ✕with single unilateral ischemic or hemorrhagic middle cerebral artery stroke;
  • ✕neurologically stable for \>6 months;
  • ✕have an expectation that current medication will be maintained without changes for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted;
  • ✕without severe spasticity (Modified Ashworth (MA) \<4);
  • ✕have not received botulinum toxin on the impaired arm within 3 months.
  • ✕Exclusion criteria for stroke group
  • ✕have an orthopedic disorder involving upper limbs;
  • ✕cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol (Montreal Cognitive Assessment (MoCA) score \< 26);
  • ✕a history of another neurologic disease;
  • ✕anesthesia of joint position sense in upper limbs;
  • ✕are pregnant or have a chance that they might be (self-reported);

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Trial data sourced from ClinicalTrials.gov.