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Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke

Sponsored by VA Office of Research and Development

About this study

Stroke is a leading cause of disability in the United States, affecting approximately 795,000 people annually. The Veteran's Health Administration provides over 60,000 outpatient visits for stroke-related care annually at a cost of over $250 million. Among ambulatory people with chronic stroke (PwCS), impaired balance is a common health concern that substantially limits mobility (those with the worst balance walk the least). This project will explore adaptive strategies employed by PwCS in balance challenging environments and if a novel gait training intervention using a robotic device to amplify a person's self-generated movements can improve walking balance. The development of effective interventions to increase walking balance among PwCS will positively impact Veterans' health, quality of life, and ability to participate in walking activities.

Background: There is a pressing need to develop effective methods to enhance walking balance in people with chronic stroke (PwCS). Interventions that amplify self-generated movements may accelerate motor learning by enhancing a person's perception of movement errors. This method could potentially be applied to help PwCS improve walking balance. To this end, the investigators have developed a cable-driven robot to create a Movement Amplification Environment (MAE) during treadmill walking. The MAE challenges walking balance by applying lateral forces to the pelvis that are proportional in magnitude to real-time lateral center of mass (COM) velocity. Unlike a popular form of balance training that uses unpredictable perturbations to enhance reactive balance, training in a MAE targets anticipa…

Where this study is enrolling (2)

Who can participate

Inclusion criteria

  • ✓History of chronic stroke (more than 6 months post-stroke) with weakness on one side
  • ✓Ability to ambulate over ground for 10 meters with or without a single cane, and/or ankle-foot orthosis
  • ✓Ability to tolerate 10 minutes of standing

Exclusion criteria

  • ✕Presence of cognitive impairment (score of 22/30 on the Montreal Cognitive Assessment scale (MoCA))
  • ✕Presence of aphasia (score of 71/100 on the Mississippi Aphasia Screening Test (MAST))
  • ✕Excessive spasticity in lower limbs (score of \> 3 on the Modified Ashworth Scale
  • ✕Severe cardiovascular and pulmonary disease affecting gait and balance
  • ✕History of recurrent fractures or known orthopedic problems in the lower extremities (i.e. heterotopic ossification) affecting gait and balance
  • ✕Concomitant central or peripheral neurological injury (i.e. traumatic head injury or peripheral nerve damage in lower limbs) affecting gait and balance
  • ✕Evidence of cerebellar ataxia
  • ✕Presence of unhealed decubiti or other skin compromise
  • ✕Enrollment in concurrent physical therapy or research involving gait or balance training
  • ✕Use of braces/orthotics crossing the knee joint
  • ✕Known pregnancy

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.