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Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)

Sponsored by Temple University

About this study

This interventional trial will compare a novel prehospital stroke transport algorithm (OPUS-i) to a traditional prehospital stroke transport algorithm to improve outcomes in rural stroke patients by determining the effect of implementing a data-driven prehospital stroke algorithm on time to and endovascular therapy. The study consists of a multicenter cohort and will last 24 months but individual subject study duration is 90 days.

Stroke is the fifth leading cause of death in the United States (U.S.) and causes one in six deaths from cardiovascular disease. Intravenous thrombolysis (IVT), unless contraindicated, is the standard of care for acute ischemic strokes (AIS) presenting within 4.5 hours of last known well. IVT plus endovascular therapy (EVT) is standard of care for the typically debilitating large vessel occlusion strokes (LVOS), which represent 30% of AIS. However, only a limited number of stroke centers provide EVT. Currently only 12% of all stroke patients are treated with IVT and only 8% of patients are treated with EVT. Therefore, optimizing prehospital systems of care to provide timely IVT and EVT to all patients. Most stroke patients arrive at the hospital by Emergency Medical Services (EMS). EMS cl…

Where this study is enrolling

Who can participate

Inclusion criteria

  • ✓Clinical impression of stroke/TIA by EMS clinicians

Exclusion criteria

  • ✕Age \< 18 years
  • ✕Prisoner

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

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Trial data sourced from ClinicalTrials.gov.