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Phase 3Recruiting

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Sponsored by National Cancer Institute (NCI)

About this study

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

PRIMARY OBJECTIVE: I. To evaluate progression-free survival (PFS) of osimertinib (AZD9291) and bevacizumab versus osimertinib (AZD9291) alone as first-line treatment for patients with metastatic EGFR-mutant lung cancers. SECONDARY OBJECTIVES: I. To evaluate overall survival (OS). II. To evaluate best objective response rate and duration of objective response. III. To evaluate time to central nervous system (CNS) progression and CNS PFS. IV. To evaluate toxicity of the combination regimen. CORRELATIVE OBJECTIVES: I. To characterize mechanisms of resistance to osimertinib (AZD9291) and osimertinib (AZD9291) with bevacizumab first-line therapy through post-progression circulating tumor-derived deoxyribonucleic acid (ctDNA). II. To assess for ctDNA clearance on study treatment and assoc…

Where this study is enrolling (325)

Show all 325 locations

  • Kaiser Permanente-Fremont

    Fremont, California

    I'm interested

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California

    I'm interested

  • Kaiser Permanente-Fresno

    Fresno, California

    I'm interested

  • Kaiser Permanente-Modesto

    Modesto, California

    I'm interested

  • Kaiser Permanente-Oakland

    Oakland, California

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  • Kaiser Permanente-Richmond

    Richmond, California

    I'm interested

  • Kaiser Permanente-Roseville

    Roseville, California

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  • Kaiser Permanente-San Francisco

    San Francisco, California

    I'm interested

  • Kaiser Permanente-Santa Rosa

    Santa Rosa, California

    I'm interested

  • Kaiser Permanente-Santa Teresa-San Jose

    San Jose, California

    I'm interested

  • Kaiser Permanente-South Sacramento

    Sacramento, California

    I'm interested

  • Kaiser Permanente-South San Francisco

    South San Francisco, California

    I'm interested

  • Kaiser Permanente-Stockton

    Stockton, California

    I'm interested

  • Washington Health

    Fremont, California

    Call 510-248-1600

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  • Kaiser Permanente-Vallejo

    Vallejo, California

    I'm interested

  • Kaiser San Rafael-Gallinas

    San Rafael, California

    I'm interested

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California

    I'm interested

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California

    I'm interested

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California

    Call 916-734-3089

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  • Kaiser Permanente Medical Center-Vacaville

    Vacaville, California

    I'm interested

  • Kaiser Permanente Dublin

    Dublin, California

    Call 877-642-4691

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  • Kaiser Permanente Fresno Orchard Plaza

    Fresno, California

    Call 833-574-2273

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  • Kaiser Permanente Downtown Commons

    Sacramento, California

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  • Kaiser Permanente- Modesto MOB II

    Modesto, California

    Call 877-642-4691

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  • Kaiser Permanente San Leandro

    San Leandro, California

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  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California

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  • Rocky Mountain Cancer Centers-Boulder

    Boulder, Colorado

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  • Rocky Mountain Cancer Centers-Aurora

    Aurora, Colorado

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  • Rocky Mountain Cancer Centers - Swedish

    Englewood, Colorado

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  • Kaiser Permanente-Rock Creek

    Lafayette, Colorado

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  • Kaiser Permanente-Lone Tree

    Lone Tree, Colorado

    I'm interested

  • Kaiser Permanente-Franklin

    Denver, Colorado

    I'm interested

  • Hartford Hospital

    Hartford, Connecticut

    Call 860-545-5363

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  • Smilow Cancer Hospital-Derby Care Center

    Derby, Connecticut

    I'm interested

  • Smilow Cancer Hospital-Torrington Care Center

    Torrington, Connecticut

    I'm interested

  • Yale University

    New Haven, Connecticut

    I'm interested

  • Yale-New Haven Hospital North Haven Medical Center

    North Haven, Connecticut

    I'm interested

  • Midstate Medical Center

    Meriden, Connecticut

    Call 866-662-5678

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  • The Hospital of Central Connecticut

    New Britain, Connecticut

    Call 860-224-5660

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  • Stamford Hospital/Bennett Cancer Center

    Stamford, Connecticut

    Call 203-323-8944

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  • Smilow Cancer Hospital Care Center at Glastonbury

    Glastonbury, Connecticut

    I'm interested

  • Smilow Cancer Hospital-Waterbury Care Center

    Waterbury, Connecticut

    I'm interested

  • Smilow Cancer Hospital Care Center at Greenwich

    Greenwich, Connecticut

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  • Smilow Cancer Hospital Care Center at Long Ridge

    Stamford, Connecticut

    I'm interested

  • Smilow Cancer Hospital Care Center at Saint Francis

    Hartford, Connecticut

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  • Smilow Cancer Hospital Care Center - Guilford

    Guilford, Connecticut

    I'm interested

  • Smilow Cancer Hospital Care Center - Waterford

    Waterford, Connecticut

    I'm interested

  • Smilow Cancer Hospital Care Center-Fairfield

    Fairfield, Connecticut

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  • Smilow Cancer Hospital Care Center-Trumbull

    Trumbull, Connecticut

    I'm interested

  • George Washington University Medical Center

    Washington D.C., District of Columbia

    Call 202-741-2210

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  • Holy Cross Hospital

    Fort Lauderdale, Florida

    I'm interested

  • Emory University Hospital Midtown

    Atlanta, Georgia

    I'm interested

  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

    Savannah, Georgia

    I'm interested

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia

    I'm interested

  • Kaiser Permanente Moanalua Medical Center

    Honolulu, Hawaii

    I'm interested

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho

    I'm interested

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho

    I'm interested

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, Idaho

    I'm interested

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho

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  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho

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  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho

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  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho

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  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho

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  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho

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  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho

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  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho

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  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois

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  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois

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  • Illinois CancerCare - Washington

    Washington, Illinois

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  • Illinois CancerCare-Bloomington

    Bloomington, Illinois

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  • Illinois CancerCare-Canton

    Canton, Illinois

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  • Illinois CancerCare-Carthage

    Carthage, Illinois

    I'm interested

  • Illinois CancerCare-Dixon

    Dixon, Illinois

    Call 815-285-7800

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  • Illinois CancerCare-Eureka

    Eureka, Illinois

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  • Illinois CancerCare-Galesburg

    Galesburg, Illinois

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  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois

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  • Illinois CancerCare-Macomb

    Macomb, Illinois

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  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois

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  • Illinois CancerCare-Pekin

    Pekin, Illinois

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  • Illinois CancerCare-Peoria

    Peoria, Illinois

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  • Illinois CancerCare-Peru

    Peru, Illinois

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  • Illinois CancerCare-Princeton

    Princeton, Illinois

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  • Ingalls Memorial Hospital

    Harvey, Illinois

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  • SSM Health Good Samaritan

    Mount Vernon, Illinois

    I'm interested

  • Springfield Memorial Hospital

    Springfield, Illinois

    I'm interested

  • Springfield Clinic

    Springfield, Illinois

    Call 800-444-7541

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  • Southern Illinois University School of Medicine

    Springfield, Illinois

    Call 217-545-7929

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  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois

    I'm interested

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois

    I'm interested

  • Rush-Copley Medical Center

    Aurora, Illinois

    I'm interested

  • Carle at The Riverfront

    Danville, Illinois

    I'm interested

  • Carle Cancer Center

    Urbana, Illinois

    I'm interested

  • Carle Physician Group-Effingham

    Effingham, Illinois

    I'm interested

  • Crossroads Cancer Center

    Effingham, Illinois

    I'm interested

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois

    I'm interested

  • Centralia Oncology Clinic

    Centralia, Illinois

    I'm interested

  • Northwestern University

    Chicago, Illinois

    I'm interested

  • Northwestern Medicine Orland Park

    Orland Park, Illinois

    I'm interested

  • Northwestern Medicine Oak Brook

    Oak Brook, Illinois

    I'm interested

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois

    I'm interested

  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois

    Call 312-695-1102

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  • University of Illinois

    Chicago, Illinois

    Call 312-355-3046

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  • Northwestern Medicine Glenview Outpatient Center

    Glenview, Illinois

    Call 312-695-1102

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  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois

    I'm interested

  • Saint Mary Medical Center

    Hobart, Indiana

    I'm interested

  • Saint Catherine Hospital

    Indianapolis, Indiana

    I'm interested

  • The Community Hospital

    Munster, Indiana

    Call 219-836-3349

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  • Women's Diagnostic Center - Munster

    Munster, Indiana

    I'm interested

  • Northwest Oncology LLC

    Dyer, Indiana

    Call 219-924-8178

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  • Northwest Cancer Center - Valparaiso

    Valparaiso, Indiana

    I'm interested

  • Northwest Cancer Center - Hobart

    Hobart, Indiana

    Call 219-947-1795

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  • Northwest Cancer Center - Crown Point

    Crown Point, Indiana

    I'm interested

  • Broadlawns Medical Center

    Des Moines, Iowa

    Call 515-282-2200

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  • Saint Anthony Regional Hospital

    Carroll, Iowa

    I'm interested

  • Mary Greeley Medical Center

    Ames, Iowa

    Call 515-956-4132

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  • McFarland Clinic - Ames

    Ames, Iowa

    I'm interested

  • McFarland Clinic - Marshalltown

    Marshalltown, Iowa

    Call 515-956-4132

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  • McFarland Clinic - Trinity Cancer Center

    Fort Dodge, Iowa

    Call 515-956-4132

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  • UI Healthcare Mission Cancer and Blood - Fort Dodge

    Fort Dodge, Iowa

    I'm interested

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa

    Call 515-241-3305

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  • Iowa Methodist Medical Center

    Des Moines, Iowa

    Call 515-241-6727

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  • Cancer Center of Kansas - Wichita

    Wichita, Kansas

    I'm interested

  • Cancer Center of Kansas-Wichita Medical Arts Tower

    Wichita, Kansas

    I'm interested

  • Ascension Via Christi Hospitals Wichita

    Wichita, Kansas

    I'm interested

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts

    I'm interested

  • Genesys Hurley Cancer Institute

    Flint, Michigan

    I'm interested

  • Hematology Oncology Consultants-Clarkston

    Clarkston, Michigan

    I'm interested

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan

    I'm interested

  • Henry Ford Health Warren Hospital

    Warren, Michigan

    I'm interested

  • Henry Ford River District Hospital

    East China Township, Michigan

    I'm interested

  • Henry Ford Saint John Hospital - Academic

    Grosse Pointe Woods, Michigan

    I'm interested

  • Henry Ford Saint John Hospital - Macomb Medical

    Macomb, Michigan

    I'm interested

  • Henry Ford Saint John Hospital - Van Elslander

    Grosse Pointe Woods, Michigan

    I'm interested

  • Henry Ford Warren Hospital - GLCMS

    Warren, Michigan

    I'm interested

  • Hurley Medical Center

    Flint, Michigan

    I'm interested

  • Huron Gastroenterology PC

    Ypsilanti, Michigan

    I'm interested

  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan

    Call 248-551-7695

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  • Corewell Health Dearborn Hospital

    Dearborn, Michigan

    Call 248-551-7695

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  • Corewell Health Beaumont Troy Hospital

    Troy, Michigan

    Call 248-551-7695

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  • Michigan Healthcare Professionals Pontiac

    Pontiac, Michigan

    I'm interested

  • MyMichigan Medical Center Saginaw

    Saginaw, Michigan

    I'm interested

  • MyMichigan Medical Center Tawas

    Tawas City, Michigan

    I'm interested

  • Newland Medical Associates-Pontiac

    Pontiac, Michigan

    I'm interested

  • Chelsea Hospital

    Chelsea, Michigan

    I'm interested

  • Cancer Hematology Centers - Flint

    Flint, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan

    I'm interested

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan

    I'm interested

  • Trinity Health Medical Center - Canton

    Canton, Michigan

    I'm interested

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan

    I'm interested

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan

    I'm interested

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan

    I'm interested

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan

    I'm interested

  • Minnesota Oncology - Burnsville

    Burnsville, Minnesota

    I'm interested

  • Regions Hospital

    Saint Paul, Minnesota

    I'm interested

  • Minnesota Oncology - Edina

    Edina, Minnesota

    I'm interested

  • Minnesota Oncology Hematology PA-Maplewood

    Maplewood, Minnesota

    I'm interested

  • Mercy Hospital

    Coon Rapids, Minnesota

    I'm interested

  • Fairview Southdale Hospital

    Edina, Minnesota

    I'm interested

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota

    I'm interested

  • Ridgeview Medical Center

    Waconia, Minnesota

    I'm interested

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota

    I'm interested

  • Saint Francis Regional Medical Center

    Shakopee, Minnesota

    I'm interested

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota

    I'm interested

  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota

    I'm interested

  • United Hospital

    Saint Paul, Minnesota

    I'm interested

  • Hennepin County Medical Center

    Minneapolis, Minnesota

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Union County

    New Albany, Mississippi

    I'm interested

  • Baptist Cancer Center-Grenada

    Grenada, Mississippi

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Desoto

    Southhaven, Mississippi

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Oxford

    Oxford, Mississippi

    I'm interested

  • Parkland Health Center - Farmington

    Farmington, Missouri

    Call 314-996-5569

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  • Mercy Hospital South

    St Louis, Missouri

    I'm interested

  • Mercy Hospital Saint Louis

    St Louis, Missouri

    Call 314-251-7066

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  • Missouri Baptist Medical Center

    St Louis, Missouri

    Call 314-996-5569

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  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri

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  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri

    Call 314-996-5569

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  • Saint Luke's Hospital

    Chesterfield, Missouri

    Call 314-205-6936

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  • Saint Francis Medical Center

    Cape Girardeau, Missouri

    I'm interested

  • Community Medical Center

    Missoula, Montana

    I'm interested

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana

    I'm interested

  • Logan Health Medical Center

    Kalispell, Montana

    I'm interested

  • Billings Clinic Cancer Center

    Billings, Montana

    I'm interested

  • Benefis Sletten Cancer Institute

    Great Falls, Montana

    I'm interested

  • Community Hospital of Anaconda

    Anaconda, Montana

    I'm interested

  • Cancer Partners of Nebraska

    Lincoln, Nebraska

    I'm interested

  • The Valley Hospital - Luckow Pavilion

    Paramus, New Jersey

    I'm interested

  • Monmouth Medical Center Southern Campus

    Lakewood, New Jersey

    I'm interested

  • Monmouth Medical Center

    Long Branch, New Jersey

    I'm interested

  • Valley Health System Ridgewood Campus

    Ridgewood, New Jersey

    I'm interested

  • Cooperman Barnabas Medical Center

    Livingston, New Jersey

    Call 973-322-5200

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  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey

    Call 732-235-7356

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  • Englewood Hospital and Medical Center

    Englewood, New Jersey

    Call 201-894-3456

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  • Jersey City Medical Center

    Jersey City, New Jersey

    I'm interested

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey

    Call 212-639-7592

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  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey

    Call 212-639-7592

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  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey

    Call 212-639-7592

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  • University of New Mexico Cancer Center

    Albuquerque, New Mexico

    I'm interested

  • State University of New York Upstate Medical University

    Syracuse, New York

    Call 315-464-5476

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  • Roswell Park Cancer Institute

    Buffalo, New York

    I'm interested

  • The Cancer Institute at Saint Francis Hospital

    East Hills, New York

    I'm interested

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York

    I'm interested

  • Dickstein Cancer Treatment Center

    White Plains, New York

    I'm interested

  • Memorial Sloan Kettering Westchester

    Harrison, New York

    Call 212-639-7592

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  • Memorial Sloan Kettering Nassau

    Uniondale, New York

    Call 212-639-7592

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  • Memorial Sloan Kettering Commack

    Commack, New York

    Call 212-639-7592

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  • Memorial Sloan Kettering Cancer Center

    New York, New York

    Call 212-639-7592

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  • Upstate Cancer Center at Verona

    Verona, New York

    I'm interested

  • Upstate Cancer Center at Oswego

    Oswego, New York

    I'm interested

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York

    I'm interested

  • Glens Falls Hospital

    Glens Falls, New York

    Call 518-926-6700

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  • Good Samaritan University Hospital

    West Islip, New York

    Call 516-326-7514

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  • Mount Sinai Chelsea

    New York, New York

    I'm interested

  • Mount Sinai Hospital

    New York, New York

    I'm interested

  • Southeastern Medical Oncology Center-Clinton

    Clinton, North Carolina

    I'm interested

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina

    I'm interested

  • Southeastern Medical Oncology Center-Jacksonville

    Jacksonville, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Mount Airy

    Mount Airy, North Carolina

    I'm interested

  • Southeastern Medical Oncology Center-Goldsboro

    Goldsboro, North Carolina

    I'm interested

  • Novant Health Forsyth Medical Center

    Winston-Salem, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Huntersville

    Huntersville, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Kernersville

    Kernersville, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Matthews

    Matthews, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Mooresville

    Mooresville, North Carolina

    I'm interested

  • Genesis Healthcare System Cancer Care Center

    Zanesville, Ohio

    I'm interested

  • Premier Blood and Cancer Center

    Dayton, Ohio

    Call 937-276-8320

    This research site can be reached directly by phone. Call to ask about this study.

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  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio

    I'm interested

  • Knox Community Hospital

    Mount Vernon, Ohio

    I'm interested

  • Miami Valley Hospital North

    Dayton, Ohio

    I'm interested

  • Case Western Reserve University

    Cleveland, Ohio

    I'm interested

  • OhioHealth Marion General Hospital

    Marion, Ohio

    I'm interested

  • Dayton Physicians LLC-Atrium

    Franklin, Ohio

    I'm interested

  • Delaware Health Center-Grady Cancer Center

    Delaware, Ohio

    I'm interested

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio

    Call 937-569-7515

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  • Doctors Hospital

    Columbus, Ohio

    I'm interested

  • Adena Regional Medical Center

    Chillicothe, Ohio

    I'm interested

  • Licking Memorial Hospital

    Newark, Ohio

    I'm interested

  • Marietta Memorial Hospital

    Marietta, Ohio

    I'm interested

  • Southern Ohio Medical Center

    Portsmouth, Ohio

    I'm interested

  • Springfield Regional Cancer Center

    Springfield, Ohio

    I'm interested

  • Cleveland Clinic Foundation

    Cleveland, Ohio

    I'm interested

  • Strecker Cancer Center-Belpre

    Belpre, Ohio

    I'm interested

  • Memorial Hospital

    Marysville, Ohio

    I'm interested

  • The Mark H Zangmeister Center

    Columbus, Ohio

    I'm interested

  • Columbus Oncology and Hematology Associates Inc

    Columbus, Ohio

    I'm interested

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio

    I'm interested

  • Grant Medical Center

    Columbus, Ohio

    I'm interested

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio

    I'm interested

  • UH Seidman Cancer Center at Southwest General Hospital

    Middleburg Heights, Ohio

    I'm interested

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio

    Call 800-641-2422

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  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio

    I'm interested

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio

    I'm interested

  • University of Cincinnati Cancer Center-West Chester

    West Chester, Ohio

    I'm interested

  • Miami Valley Hospital

    Dayton, Ohio

    I'm interested

  • Miami Valley Hospital South

    Centerville, Ohio

    I'm interested

  • Integris Cancer Institute of Oklahoma

    Oklahoma City, Oklahoma

    Call 405-773-6613

    This research site can be reached directly by phone. Call to ask about this study.

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  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma

    I'm interested

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon

    I'm interested

  • Saint Charles Health System

    Bend, Oregon

    I'm interested

  • Providence Portland Medical Center

    Portland, Oregon

    I'm interested

  • Providence Saint Vincent Medical Center

    Portland, Oregon

    I'm interested

  • WellSpan Health-York Cancer Center

    York, Pennsylvania

    Call 877-441-7957

    This research site can be reached directly by phone. Call to ask about this study.

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  • WellSpan Health-York Hospital

    York, Pennsylvania

    Call 877-441-7957

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  • Paoli Memorial Hospital

    Paoli, Pennsylvania

    I'm interested

  • Guthrie Medical Group PC-Robert Packer Hospital

    Sayre, Pennsylvania

    Call 800-836-0388

    This research site can be reached directly by phone. Call to ask about this study.

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  • Ephrata Cancer Center

    Ephrata, Pennsylvania

    Call 717-721-4840

    This research site can be reached directly by phone. Call to ask about this study.

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  • WellSpan Medical Oncology and Hematology

    Hanover, Pennsylvania

    Call 717-632-1559

    This research site can be reached directly by phone. Call to ask about this study.

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  • Lankenau Medical Center

    Wynnewood, Pennsylvania

    I'm interested

  • Adams Cancer Center

    Gettysburg, Pennsylvania

    Call 877-441-7957

    This research site can be reached directly by phone. Call to ask about this study.

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  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania

    I'm interested

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania

    I'm interested

  • Riddle Memorial Hospital

    Media, Pennsylvania

    I'm interested

  • WellSpan Medical Oncology and Hematology

    Chambersburg, Pennsylvania

    Call 717-217-6020

    This research site can be reached directly by phone. Call to ask about this study.

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  • Sechler Family Cancer Center

    Lebanon, Pennsylvania

    I'm interested

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania

    I'm interested

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania

    I'm interested

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota

    I'm interested

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee

    I'm interested

  • Methodist Willowbrook Hospital

    Houston, Texas

    I'm interested

  • Parkland Memorial Hospital

    Dallas, Texas

    I'm interested

  • Houston Methodist Saint John Hospital

    Nassau Bay, Texas

    I'm interested

  • Houston Methodist San Jacinto Hospital

    Baytown, Texas

    I'm interested

  • Houston Methodist Sugar Land Hospital

    Sugar Land, Texas

    Call 281.274.7000

    This research site can be reached directly by phone. Call to ask about this study.

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  • Houston Methodist Hospital

    Houston, Texas

    Call 713.790.3311

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  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas

    I'm interested

  • Houston Methodist West Hospital

    Houston, Texas

    Call 832.522.6070

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  • Houston Methodist The Woodlands Hospital

    The Woodlands, Texas

    I'm interested

  • Houston Methodist Cypress Hospital

    Cypress, Texas

    I'm interested

  • University of Virginia Cancer Center

    Charlottesville, Virginia

    I'm interested

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington

    I'm interested

  • West Virginia University Charleston Division

    Charleston, West Virginia

    Call 304-388-9944

    This research site can be reached directly by phone. Call to ask about this study.

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  • Marshfield Medical Center - Weston

    Weston, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Oshkosh

    Oshkosh, Wisconsin

    I'm interested

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin

    I'm interested

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin

    Call 262-928-7878

    This research site can be reached directly by phone. Call to ask about this study.

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  • ProHealth Waukesha Memorial Hospital

    Waukesha, Wisconsin

    Call 262-928-7632

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  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin

    I'm interested

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - New London

    New London, Wisconsin

    I'm interested

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Berlin

    Berlin, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Shawano

    Shawano, Wisconsin

    I'm interested

  • Mercyhealth Hospital and Cancer Center - Janesville

    Janesville, Wisconsin

    I'm interested

  • ThedaCare Regional Medical Center - Neenah

    Neenah, Wisconsin

    I'm interested

  • ThedaCare Regional Cancer Center

    Appleton, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Waupaca

    Waupaca, Wisconsin

    I'm interested

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin

    I'm interested

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin

    I'm interested

  • Medical College of Wisconsin

    Milwaukee, Wisconsin

    Call 414-805-3666

    This research site can be reached directly by phone. Call to ask about this study.

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  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin

    I'm interested

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin

    I'm interested
Who can participate

Inclusion criteria

  • ✓Patient must have a pathologically-confirmed diagnosis of non-squamous, non-small cell lung cancer (NSCLC)
  • ✓Patient must have advanced disease, defined as - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria
  • ✓Patient must have somatic activating sensitizing mutation in EGFR (e.g. but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Test results originating from a Clinical Laboratory Improvement Act (CLIA)-certified or similarly accredited laboratory are acceptable; no specific assay is mandated. Plasma, cytology, or tumor tissue can be utilized for mutation testing
  • ✓Patient must not have received any prior treatment with an anti-VEGF agent
  • ✓NOTE: Prior treatment with an EGFR TKI is not allowed, however if a candidate for this study has already started osimertinib within 21 days prior to randomization, the exact osimertinib start date is known, and the patient had the required study baseline imaging completed prior to the osimertinib start date, the patient will be eligible
  • ✓Patients that have received prior radiation therapy are eligible. Radiation (limited field stereotactic radiation or conventional radiation) must have been completed at least one week prior to study drug initiation and more extensive field radiation (i.e., whole-brain radiotherapy \[WBRT\]) must have been completed at least two weeks prior to drug initiation
  • ✓Patient must not have any risk factors for anti-VEGF administration, specifically, hemoptysis, active cardiovascular disease, uncontrolled hypertension, significant proteinuria (screening urinalysis \> 300 mg/dl) and tumor invading major blood vessels
  • ✓Patient must have measurable disease. Baseline measurements of sites of disease must be obtained within 4 weeks prior to study randomization. If a potential target lesion is previously irradiated without subsequent growth and/or is radiated after the imaging from which baseline measurements are obtained, they cannot be included as target lesions, and additional target lesions are required to meet criteria for measurable disease
  • ✓Patient must not have had any prior systemic treatment for metastatic disease
  • ✓Patient must be ≥ 18 years of age
  • ✓Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
  • ✓Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used
  • ✓All females of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy
  • ✓A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • ✓Patient of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for 2 weeks prior to the start of treatment, while on study treatment, and for
  • ✓6 weeks after the last dose of protocol treatment for female patients on the osimertinib (AZD9291) alone arm
  • ✓4 months after the last dose of protocol treatment for male patients on osimertinib (AZD9291) alone arm
  • ✓6 months after the last dose of protocol treatment for all patients on osimertinib (AZD9291) plus bevacizumab combination arm
  • ✓NOTE: Female patients should also not breastfeed while on treatment and for 6 months after the last dose bevacizumab
  • ✓Leukocytes \>= 3,000/mcL (obtained =\< 14 days prior to randomization)
  • ✓Absolute neutrophil count \>= 1,500/mcL (obtained =\< 14 days prior to randomization)
  • ✓Platelets \>= 100,000/mcL (obtained =\< 14 days prior to randomization)
  • ✓Hemoglobin \>= 9 g/dL (obtained =\< 14 days prior to randomization)
  • ✓Total bilirubin and creatinine =\< 1.5 x institutional upper limit of normal (ULN) (obtained =\< 14 days prior to randomization)
  • ✓Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (obtained =\< 14 days prior to randomization)
  • ✓Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
  • ✓For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
  • ✓Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
  • ✓Patients with treated brain metastases are eligible if neurologically stable without glucocorticoid therapy after the stated washout period from radiation therapy (RT) or surgery provided the metastatic lesions are non-hemorrhagic
  • ✓Patients with untreated brain metastases or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required provided the metastatic lesions are non-hemorrhagic and are neurologically stable without glucocorticoid therapy
  • ✓Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
  • ✓Patients with known history or current symptoms of cardiac disease, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
  • ✓Patient must have the ability to understand and the willingness to sign a written informed consent document and comply with study requirements
  • ✓Patient must not have had treatment with any investigational drug within five half-lives or 3 months (whichever is greater), prior to study initiation
  • ✓Patient must not be currently receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be strong inducers of CYP3A4. For any patient currently receiving such inducers of CYP3A4, they must discontinue use prior to first dose of study treatment. All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foods with known inducer effects on CYP3A4
  • ✓Patient must not have any unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 at the time of randomization, with the exception of alopecia and grade 2 prior platinum-therapy-related neuropathy
  • ✓Patient must not have any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses, which in the investigator's opinion makes it challenging for the patient to participate in the study. Screening for chronic conditions is not required
  • ✓Patient must not have refractory nausea and vomiting, chronic gastrointestinal diseases, the inability to swallow the osimertinib tablets or previous significant bowel resection that would preclude adequate absorption of osimertinib
  • ✓Patient must not have a medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease
  • ✓Patient must not have a history of hypersensitivity to active or inactive excipients of osimertinib or drugs with a similar chemical structure or class to osimertinib
  • ✓Patient must not have mean resting corrected QT interval (QTc) \> 470 msec obtained from 3 electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc value (using Bazett's correction)
  • ✓Patient must not have any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g. complete left bundle branch block, third degree heart block and second-degree heart block
  • ✓Patient must not have any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: potassium \< lower limit of normal \[LLN\]; magnesium \< LLN; calcium \< LLN), congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval and cause torsades de pointes

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.