Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Sponsored by Alliance for Clinical Trials in Oncology
About this study
This phase III trial compares the effect of continuation of treatment with pembrolizumab (usual approach) to observation only at preventing cancer from coming back in patients with early-stage triple-negative breast cancer (TNBC) who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. The usual approach for patients with early-stage TNBC who receive preoperative chemotherapy plus pembrolizumab is to continue to receive pembrolizumab for up to 27 weeks after surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observation is as good as receiving pembrolizumab for 27 weeks after surgery in triple-negative breast cancer patients who achieved a pathologic complete response after preoperative treatment with chemotherapy and pembrolizumab.
PRIMARY OBJECTIVES: I. To evaluate whether observation results in a non-inferior recurrence-free survival (RFS) compared to adjuvant pembrolizumab in early-stage triple-negative breast cancer (TNBC) patients who achieve a pathologic complete response (pCR) after neoadjuvant chemotherapy with pembrolizumab. II. To compare quality of life (QOL) at approximately 27 weeks as assessed by the Functional Assessment of Cancer Therapy-Breast (FACT-B) Trial Outcome Index between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) III. To assess the social value of de-escalation of adjuvant breast cancer immunotherapy at approximately 27 weeks and, by modeling, over a lifetime. (Value of Care) SECONDARY OBJECTIVES: I. To evaluate whether observation compared to adj…
Where this study is enrolling (779)
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Mobile Infirmary Medical Center
Mobile, Alabama
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University of South Alabama Mitchell Cancer Institute
Mobile, Alabama
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Thomas Hospital
Fairhope, Alabama
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Katmai Oncology Group
Anchorage, Alaska
- Call 623-207-3000
CTCA at Western Regional Medical Center
Goodyear, Arizona
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- Call +1 480-342-2000
Mayo Clinic Hospital in Arizona
Phoenix, Arizona
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Cancer Center at Saint Joseph's
Phoenix, Arizona
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Kingman Regional Medical Center
Kingman, Arizona
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Highlands Oncology Group - Fayetteville
Fayetteville, Arkansas
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Highlands Oncology Group
Springdale, Arkansas
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Highlands Oncology Group - Rogers
Rogers, Arkansas
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University of Arkansas for Medical Sciences
Little Rock, Arkansas
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NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas
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Kaiser Permanente- Modesto MOB II
Modesto, California
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Modesto, California
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Kaiser Permanente-Oakland
Oakland, California
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Saint Joseph Hospital - Orange
Orange, California
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Desert Regional Medical Center
Palm Springs, California
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Huntington Memorial Hospital
Pasadena, California
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Rancho Mirage, California
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Kaiser Permanente-Roseville
Roseville, California
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Kaiser Permanente Downtown Commons
Sacramento, California
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University of California Davis Comprehensive Cancer Center
Sacramento, California
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Sacramento, California
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Salinas Valley Memorial
Salinas, California
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San Francisco, California
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San Francisco, California
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San Jose, California
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San Jose, California
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San Leandro, California
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San Mateo, California
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San Rafael, California
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Santa Clara, California
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Mission Hope Medical Oncology - Santa Maria
Santa Maria, California
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Saint John's Cancer Institute
Santa Monica, California
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Santa Rosa, California
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South San Francisco, California
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Cedars-Sinai Cancer - Tarzana
Tarzana, California
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Torrance Memorial Physician Network - Cancer Care
Torrance, California
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Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California
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Kaiser Permanente-Vallejo
Vallejo, California
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Walnut Creek, California
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Woodland Memorial Hospital
Woodland, California
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Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California
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Mercy Cancer Center - Carmichael
Carmichael, California
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Fresno, California
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Rocklin, California
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Sacramento, California
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Sacramento, California
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Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California
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Kaiser Permanente Dublin
Dublin, California
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Mercy Cancer Center - Elk Grove
Elk Grove, California
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Enloe Medical Center
Chico, California
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PCR Oncology
Arroyo Grande, California
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Mercy San Juan Medical Center
Carmichael, California
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Marshall Cancer Center
Cameron Park, California
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Tower Cancer Research Foundation
Beverly Hills, California
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Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California
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Stanford Cancer Center Emeryville
Emeryville, California
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Kaiser Permanente-Fremont
Fremont, California
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Kaiser Permanente Fresno Orchard Plaza
Fresno, California
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Loma Linda University Medical Center
Loma Linda, California
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Los Angeles, California
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Marysville, California
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Colorado Springs, Colorado
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Aurora, Colorado
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Colorado Springs, Colorado
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Denver, Colorado
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Denver, Colorado
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Denver, Colorado
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Highlands Ranch, Colorado
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Lafayette, Colorado
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Littleton, Colorado
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Lone Tree, Colorado
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Lone Tree, Colorado
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Parker, Colorado
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Westminster, Colorado
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Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut
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Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut
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Waterbury, Connecticut
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Trumbull, Connecticut
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Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut
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Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut
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Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport, Connecticut
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Danbury Hospital
Danbury, Connecticut
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut
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Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut
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Hartford Hospital
Hartford, Connecticut
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- Call 866-662-5678
Midstate Medical Center
Meriden, Connecticut
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The Hospital of Central Connecticut
New Britain, Connecticut
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Yale University
New Haven, Connecticut
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North Haven, Connecticut
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Norwalk Hospital
Norwalk, Connecticut
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Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut
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Beebe Health Campus
Rehoboth Beach, Delaware
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Medical Oncology Hematology Consultants PA
Newark, Delaware
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Helen F Graham Cancer Center
Newark, Delaware
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Beebe South Coastal Health Campus
Millville, Delaware
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia
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Kaiser Permanente-Capitol Hill Medical Center
Washington D.C., District of Columbia
- Call 202-877-8839
MedStar Washington Hospital Center
Washington D.C., District of Columbia
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Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida
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Mease Countryside Hospital
Safety Harbor, Florida
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Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida
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Broward Health Medical Center
Fort Lauderdale, Florida
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Schulze Family Foundation Cancer Clinic - Bonita Health Center
Bonita Springs, Florida
- Call 855-314-8646
Morton Plant Hospital
Clearwater, Florida
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Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida
- Call 904-202-7468
Baptist MD Anderson Cancer Center
Jacksonville, Florida
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Orlando Health Cancer Institute - Lake Mary
Lake Mary, Florida
- Call 855-776-0015
Mayo Clinic in Florida
Jacksonville, Florida
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Mount Sinai Medical Center
Miami Beach, Florida
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Health Central
Ocoee, Florida
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Orlando Health Cancer Institute
Orlando, Florida
- Call 954-265-4325
Memorial Hospital West
Pembroke Pines, Florida
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Tallahassee Memorial HealthCare
Tallahassee, Florida
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Grady Health System
Atlanta, Georgia
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia
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Emory Saint Joseph's Hospital
Atlanta, Georgia
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Northside Hospital
Atlanta, Georgia
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Emory Decatur Hospital
Decatur, Georgia
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Northside Hospital - Duluth
Duluth, Georgia
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Emory Johns Creek Hospital
Johns Creek, Georgia
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Northside Hospital - Gwinnett
Lawrenceville, Georgia
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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia
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Emory University Hospital Midtown
Atlanta, Georgia
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Queen's Medical Center
Honolulu, Hawaii
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Straub Clinic and Hospital
Honolulu, Hawaii
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Queen's Cancer Cenrer - POB I
Honolulu, Hawaii
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Pali Momi Medical Center
‘Aiea, Hawaii
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The Queen's Medical Center - West Oahu
‘Ewa Beach, Hawaii
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Queen's Cancer Center - Kuakini
Honolulu, Hawaii
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Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii
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Kapiolani Medical Center for Women and Children
Honolulu, Hawaii
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Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii
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Hawaii Cancer Care - Westridge
‘Aiea, Hawaii
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Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho
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Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho
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Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho
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Saint Luke's Cancer Institute - Boise
Boise, Idaho
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Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho
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Saint Luke's Cancer Institute - Meridian
Meridian, Idaho
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Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho
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Saint Luke's Cancer Institute - Nampa
Nampa, Idaho
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Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho
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Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho
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Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho
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Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois
- Call 708-226-4357
Loyola University Medical Center
Maywood, Illinois
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- Call 309-779-2000
Trinity Medical Center
Moline, Illinois
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SSM Health Good Samaritan
Mount Vernon, Illinois
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UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois
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Carle BroMenn Medical Center
Normal, Illinois
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Carle Cancer Institute Normal
Normal, Illinois
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Cancer Care Center of O'Fallon
O'Fallon, Illinois
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Northwestern Medicine Oak Brook
Oak Brook, Illinois
- Call 800-323-8622
Advocate Christ Medical Center
Oak Lawn, Illinois
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Northwestern Medicine Orland Park
Orland Park, Illinois
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University of Chicago Medicine-Orland Park
Orland Park, Illinois
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Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois
- Call 847-384-3621
Advocate Lutheran General Hospital
Park Ridge, Illinois
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Illinois CancerCare-Pekin
Pekin, Illinois
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Illinois CancerCare-Peoria
Peoria, Illinois
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Illinois CancerCare-Peru
Peru, Illinois
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Illinois CancerCare-Princeton
Princeton, Illinois
- Call 815-227-2633
OSF Saint Anthony Medical Center
Rockford, Illinois
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UW Health Carbone Cancer Center Rockford
Rockford, Illinois
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Memorial Hospital East
Shiloh, Illinois
- Call 217-545-7929
Southern Illinois University School of Medicine
Springfield, Illinois
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Springfield Clinic
Springfield, Illinois
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Carle Cancer Center
Urbana, Illinois
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Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois
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Illinois CancerCare - Washington
Washington, Illinois
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Advocate Good Shepherd Hospital
Barrington, Illinois
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Illinois CancerCare-Bloomington
Bloomington, Illinois
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Illinois CancerCare-Canton
Canton, Illinois
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SIH Cancer Institute
Carterville, Illinois
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Illinois CancerCare-Carthage
Carthage, Illinois
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Centralia Oncology Clinic
Centralia, Illinois
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Mount Sinai Hospital Medical Center
Chicago, Illinois
- Call (312) 864-0200
John H Stroger Jr Hospital of Cook County
Chicago, Illinois
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- Call 312-355-3046
University of Illinois
Chicago, Illinois
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Swedish Covenant Hospital
Chicago, Illinois
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AMG Crystal Lake - Oncology
Crystal Lake, Illinois
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Carle at The Riverfront
Danville, Illinois
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Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois
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Rush-Copley Medical Center
Aurora, Illinois
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Springfield Memorial Hospital
Springfield, Illinois
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Advocate Illinois Masonic Medical Center
Chicago, Illinois
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois
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Northwestern University
Chicago, Illinois
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AMG Libertyville - Oncology
Libertyville, Illinois
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Advocate Outpatient Center - Aurora
Aurora, Illinois
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Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois
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Decatur Memorial Hospital
Decatur, Illinois
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Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois
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Illinois CancerCare-Dixon
Dixon, Illinois
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Advocate Good Samaritan Hospital
Downers Grove, Illinois
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Carle Physician Group-Effingham
Effingham, Illinois
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Crossroads Cancer Center
Effingham, Illinois
- Call 847-429-2907
Advocate Sherman Hospital
Elgin, Illinois
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Illinois CancerCare-Eureka
Eureka, Illinois
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Evanston, Illinois
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Illinois CancerCare-Galesburg
Galesburg, Illinois
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Northwestern Medicine Cancer Center Delnor
Geneva, Illinois
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NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois
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Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois
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Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois
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Ingalls Memorial Hospital
Harvey, Illinois
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Advocate South Suburban Hospital
Hazel Crest, Illinois
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Highland Park, Illinois
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Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois
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Condell Memorial Hospital
Libertyville, Illinois
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Illinois CancerCare-Macomb
Macomb, Illinois
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Northwest Cancer Center - Valparaiso
Valparaiso, Indiana
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Northwest Cancer Center - Crown Point
Crown Point, Indiana
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UChicago Medicine Northwest Indiana
Crown Point, Indiana
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Northwest Oncology LLC
Dyer, Indiana
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Parkview Regional Medical Center
Fort Wayne, Indiana
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Saint Mary Medical Center
Hobart, Indiana
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Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana
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Saint Catherine Hospital
Indianapolis, Indiana
- Call 219-836-3349
The Community Hospital
Munster, Indiana
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Women's Diagnostic Center - Munster
Munster, Indiana
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Baptist Health Floyd
New Albany, Indiana
- Call 800-284-7370
Memorial Hospital of South Bend
South Bend, Indiana
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Northwest Cancer Center - Hobart
Hobart, Indiana
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Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana
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UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa
- Call 800-237-1225
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa
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- Call 515-241-3305
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa
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- I'm interested
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa
- I'm interested
Saint Anthony Regional Hospital
Carroll, Iowa
- Call 319-297-2900
Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa
This research site can be reached directly by phone. Call to ask about this study.
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- Call 319-365-4673
Mercy Hospital
Cedar Rapids, Iowa
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- Call 319-363-2690
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa
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- Call 515-241-3305
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa
This research site can be reached directly by phone. Call to ask about this study.
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- Call 515-241-6727
Iowa Methodist Medical Center
Des Moines, Iowa
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- Call 515-241-3305
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa
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- Call 515-241-3305
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa
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- Call 515-282-2200
Broadlawns Medical Center
Des Moines, Iowa
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- Call 515-241-3305
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa
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- I'm interested
Cancer Center of Kansas - Chanute
Chanute, Kansas
- I'm interested
Cancer Center of Kansas - Wellington
Wellington, Kansas
- I'm interested
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas
- I'm interested
Ascension Via Christi Hospitals Wichita
Wichita, Kansas
- I'm interested
Cancer Center of Kansas - Wichita
Wichita, Kansas
- I'm interested
Cancer Center of Kansas - Winfield
Winfield, Kansas
- I'm interested
Cancer Center of Kansas - Pratt
Pratt, Kansas
- I'm interested
Cancer Center of Kansas - Parsons
Parsons, Kansas
- I'm interested
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas
- I'm interested
The University of Kansas Cancer Center - Olathe
Olathe, Kansas
- I'm interested
Cancer Center of Kansas - Newton
Newton, Kansas
- I'm interested
Cancer Center of Kansas - McPherson
McPherson, Kansas
- I'm interested
Cancer Center of Kansas-Liberal
Liberal, Kansas
- I'm interested
Lawrence Memorial Hospital
Lawrence, Kansas
- I'm interested
Cancer Center of Kansas-Kingman
Kingman, Kansas
- I'm interested
University of Kansas Cancer Center
Kansas City, Kansas
- I'm interested
Cancer Center of Kansas-Independence
Independence, Kansas
- Call 785-623-5774
HaysMed
Hays, Kansas
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Cancer Center of Kansas - El Dorado
El Dorado, Kansas
- I'm interested
Cancer Center of Kansas - Dodge City
Dodge City, Kansas
- Call 785-295-8000
University of Kansas Health System Saint Francis Campus
Topeka, Kansas
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- I'm interested
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas
- I'm interested
Menorah Medical Center
Overland Park, Kansas
- I'm interested
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas
- I'm interested
Cancer Center of Kansas - Salina
Salina, Kansas
- I'm interested
Salina Regional Health Center
Salina, Kansas
- Call 270-706-5470
Baptist Health Hardin
Elizabethtown, Kentucky
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- Call 859-523-1934
Baptist Health Corbin
Corbin, Kentucky
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- Call 502-562-3429
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky
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- Call 859-257-3379
University of Kentucky/Markey Cancer Center
Lexington, Kentucky
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- I'm interested
CommonSpirit Saint Joseph Medical Center - East Lexington
Lexington, Kentucky
- Call 866-213-3025
Baptist Health Hamburg
Lexington, Kentucky
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- Call 859-257-3379
Markey Cancer Center at Lexington Clinic
Lexington, Kentucky
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- Call 859-260-6425
Baptist Health Lexington
Lexington, Kentucky
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- I'm interested
UofL Health Medical Center Northeast
Louisville, Kentucky
- I'm interested
Baptist Health Louisville
Louisville, Kentucky
- I'm interested
Ochsner LSU Health Monroe Medical Center
Monroe, Louisiana
- I'm interested
University Medical Center New Orleans
New Orleans, Louisiana
- I'm interested
Touro Infirmary
New Orleans, Louisiana
- I'm interested
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington, Louisiana
- I'm interested
Ochsner Medical Center Jefferson
New Orleans, Louisiana
- I'm interested
LSU Health Sciences Center at Shreveport
Shreveport, Louisiana
- I'm interested
CHRISTUS Highland Medical Center
Shreveport, Louisiana
- Call 318-813-1406
Ochsner LSU Health - Cancer Treatment Center
Shreveport, Louisiana
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- I'm interested
Ochsner High Grove
Baton Rouge, Louisiana
- I'm interested
Medical Center of Baton Rouge
Baton Rouge, Louisiana
- I'm interested
Kaiser Permanente-Woodlawn Medical Center
Baltimore, Maryland
- I'm interested
Luminis Health Anne Arundel Medical Center
Annapolis, Maryland
- Call 800-888-8823
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 443-849-3706
Greater Baltimore Medical Center
Baltimore, Maryland
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- Call 410-601-9083
Sinai Hospital of Baltimore
Baltimore, Maryland
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- Call 301-319-2100
Walter Reed National Military Medical Center
Bethesda, Maryland
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- Call 301-877-4673
MedStar Southern Maryland Hospital Center
Clinton, Maryland
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Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg, Maryland
- Call 410-553-8100
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland
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- I'm interested
Kaiser Permanente - Largo Medical Center
Largo, Maryland
- I'm interested
Kaiser Permanente Lutherville - Timonium Medical Center
Lutherville, Maryland
- Call 410-871-6400
William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 301-668-7043
FMH James M Stockman Cancer Institute
Frederick, Maryland
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- Call 617-638-8265
Boston Medical Center
Boston, Massachusetts
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- Call 617-667-9925
Beth Israel Deaconess Medical Center
Boston, Massachusetts
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- Call 877-442-3324
Dana-Farber Cancer Institute
Boston, Massachusetts
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- Call 877-338-7425
Dana-Farber Cancer Institute at Foxborough
Foxborough, Massachusetts
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- Call 877-338-7425
Dana Farber-Merrimack Valley
Methuen, Massachusetts
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- Call 781-624-5000
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth, Massachusetts
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- I'm interested
Baystate Medical Center
Springfield, Massachusetts
- I'm interested
Tufts Medical Center Cancer Center Stoneham
Stoneham, Massachusetts
- I'm interested
Tufts Medical Center
Boston, Massachusetts
- I'm interested
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan
- I'm interested
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan
- I'm interested
Allegiance Health
Jackson, Michigan
- I'm interested
Bronson Methodist Hospital
Kalamazoo, Michigan
- I'm interested
West Michigan Cancer Center
Kalamazoo, Michigan
- Call 574-647-7370
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
University of Michigan Health - Sparrow Lansing
Lansing, Michigan
- I'm interested
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan
- I'm interested
Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan
- I'm interested
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan
- Call 616-391-1230
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan
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- I'm interested
MyMichigan Medical Center Tawas
Tawas City, Michigan
- I'm interested
Munson Medical Center
Traverse City, Michigan
- I'm interested
Henry Ford Health Warren Hospital
Warren, Michigan
- I'm interested
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan
- I'm interested
Henry Ford Wyandotte Hospital
Wyandotte, Michigan
- I'm interested
University of Michigan Health - West
Wyoming, Michigan
- I'm interested
Huron Gastroenterology PC
Ypsilanti, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan
- I'm interested
Corewell Health Reed City Hospital
Reed City, Michigan
- I'm interested
MyMichigan Medical Center Saginaw
Saginaw, Michigan
- I'm interested
Henry Ford Medical Center-Columbus
Novi, Michigan
- I'm interested
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan
- I'm interested
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan
- I'm interested
Henry Ford Health Providence Novi Hospital
Novi, Michigan
- I'm interested
Henry Ford Warren Hospital - GLCMS
Warren, Michigan
- I'm interested
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan
- I'm interested
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan
- I'm interested
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan
- I'm interested
Bronson Battle Creek
Battle Creek, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan
- I'm interested
Trinity Health Medical Center - Brighton
Brighton, Michigan
- I'm interested
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan
- I'm interested
Trinity Health Medical Center - Canton
Canton, Michigan
- I'm interested
Chelsea Hospital
Chelsea, Michigan
- I'm interested
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan
- I'm interested
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan
- I'm interested
Cancer Hematology Centers - Flint
Flint, Michigan
- I'm interested
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan
- I'm interested
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan
- I'm interested
Henry Ford Medical Center-Fairlane
Dearborn, Michigan
- I'm interested
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan
- I'm interested
Henry Ford Hospital
Detroit, Michigan
- I'm interested
Henry Ford Health Saint John Hospital
Detroit, Michigan
- I'm interested
Henry Ford River District Hospital
East China Township, Michigan
- I'm interested
Genesys Hurley Cancer Institute
Flint, Michigan
- I'm interested
Hurley Medical Center
Flint, Michigan
- I'm interested
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan
- I'm interested
Saint Luke's Hospital of Duluth
Duluth, Minnesota
- I'm interested
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota
- I'm interested
Essentia Health - Deer River Clinic
Deer River, Minnesota
- I'm interested
Essentia Health Cancer Center
Duluth, Minnesota
- I'm interested
Fairview Southdale Hospital
Edina, Minnesota
- I'm interested
Minnesota Oncology - Edina
Edina, Minnesota
- Call 218-786-3308
Essentia Health Hibbing Clinic
Hibbing, Minnesota
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- I'm interested
Saint John's Hospital - Healtheast
Maplewood, Minnesota
- I'm interested
Abbott-Northwestern Hospital
Minneapolis, Minnesota
- I'm interested
Hennepin County Medical Center
Minneapolis, Minnesota
- Call 612-624-2620
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota
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- I'm interested
North Memorial Medical Health Center
Robbinsdale, Minnesota
- Call 855-776-0015
Mayo Clinic in Rochester
Rochester, Minnesota
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- I'm interested
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota
- I'm interested
Regions Hospital
Saint Paul, Minnesota
- I'm interested
United Hospital
Saint Paul, Minnesota
- I'm interested
Essentia Health Sandstone
Sandstone, Minnesota
- Call 605-312-3320
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota
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- I'm interested
Essentia Health Virginia Clinic
Virginia, Minnesota
- I'm interested
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota
- Call 605-312-3320
Sanford Cancer Center Worthington
Worthington, Minnesota
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- I'm interested
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota
- I'm interested
Minnesota Oncology - Burnsville
Burnsville, Minnesota
- I'm interested
Mercy Hospital
Coon Rapids, Minnesota
- I'm interested
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota
- I'm interested
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi
- Call 601-815-6700
University of Mississippi Medical Center
Jackson, Mississippi
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- I'm interested
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi
- I'm interested
Baptist Cancer Center-Grenada
Grenada, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi
- Call 573-882-7440
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 417-269-4520
Mercy Hospital Springfield
Springfield, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 314-996-5569
Missouri Baptist Sullivan Hospital
Sullivan, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 314-251-7066
Mercy Hospital Saint Louis
St Louis, Missouri
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- Call 314-996-5569
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri
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- I'm interested
Heartland Regional Medical Center
Saint Joseph, Missouri
- I'm interested
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri
- I'm interested
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri
- I'm interested
University of Kansas Cancer Center - North
Kansas City, Missouri
- I'm interested
Research Medical Center
Kansas City, Missouri
- Call 913-588-3671
University of Kansas Cancer Center - Briarcliff
Kansas City, Missouri
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Saint Luke's Hospital of Kansas City
Kansas City, Missouri
- Call 816-404-4375
University Health Truman Medical Center
Kansas City, Missouri
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Centerpoint Medical Center LLC
Independence, Missouri
- Call 314-996-5569
Parkland Health Center - Farmington
Farmington, Missouri
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- I'm interested
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri
- I'm interested
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri
- I'm interested
Saint Francis Medical Center
Cape Girardeau, Missouri
- Call 888-446-3729
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri
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- I'm interested
Lake Regional Hospital
Osage Beach, Missouri
- I'm interested
Siteman Cancer Center at Christian Hospital
St Louis, Missouri
- Call 314-996-5569
Missouri Baptist Medical Center
St Louis, Missouri
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- I'm interested
Siteman Cancer Center-South County
St Louis, Missouri
- I'm interested
Mercy Hospital South
St Louis, Missouri
- I'm interested
Washington University School of Medicine
St Louis, Missouri
- Call 417-269-4520
CoxHealth South Hospital
Springfield, Missouri
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- I'm interested
Logan Health Medical Center
Kalispell, Montana
- I'm interested
Bozeman Health Deaconess Hospital
Bozeman, Montana
- I'm interested
Billings Clinic Cancer Center
Billings, Montana
- I'm interested
Community Hospital of Anaconda
Anaconda, Montana
- I'm interested
Saint Patrick Hospital - Community Hospital
Missoula, Montana
- I'm interested
Community Medical Center
Missoula, Montana
- I'm interested
Benefis Sletten Cancer Institute
Great Falls, Montana
- I'm interested
Fred and Pamela Buffett Cancer Center - Kearney
Kearney, Nebraska
- I'm interested
Nebraska Medicine-Bellevue
Bellevue, Nebraska
- I'm interested
University of Nebraska Medical Center
Omaha, Nebraska
- Call 402-460-5899
Mary Lanning Memorial Hospital
Hastings, Nebraska
This research site can be reached directly by phone. Call to ask about this study.
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- Call 402-334-4773
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska
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- Call 402-559-5600
Nebraska Medicine-Village Pointe
Omaha, Nebraska
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OptumCare Cancer Care at Charleston
Las Vegas, Nevada
- I'm interested
Renown Regional Medical Center
Reno, Nevada
- I'm interested
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada
- I'm interested
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire
- Call 603-224-2556
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire
This research site can be reached directly by phone. Call to ask about this study.
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- Call 800-339-6484
Solinsky Center for Cancer Care
Manchester, New Hampshire
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- I'm interested
The Dana-Farber Cancer Institute at Londonderry
Londonderry, New Hampshire
- Call 609-631-6946
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey
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- Call 856-325-6757
Cooper Hospital University Medical Center
Camden, New Jersey
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Jefferson Cherry Hill Hospital
Cherry Hill, New Jersey
- Call 908-994-8000
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Elizabeth, New Jersey
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- Call 201-894-3456
Englewood Hospital and Medical Center
Englewood, New Jersey
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- Call 551-996-2897
Hackensack University Medical Center
Hackensack, New Jersey
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- I'm interested
Jersey City Medical Center
Jersey City, New Jersey
- I'm interested
Monmouth Medical Center Southern Campus
Lakewood, New Jersey
- Call 973-322-5200
Cooperman Barnabas Medical Center
Livingston, New Jersey
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Monmouth Medical Center
Long Branch, New Jersey
- I'm interested
MD Anderson Cancer Center at Cooper - Moorestown
Moorestown, New Jersey
- Call 973-971-5900
Morristown Medical Center
Morristown, New Jersey
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- Call 732-235-7356
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey
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- I'm interested
Newark Beth Israel Medical Center
Newark, New Jersey
- I'm interested
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey
- I'm interested
Saint Joseph's Regional Medical Center
Paterson, New Jersey
- I'm interested
Valley Health System Ridgewood Campus
Ridgewood, New Jersey
- I'm interested
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey
- Call 908-522-2043
Overlook Hospital
Summit, New Jersey
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- I'm interested
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey
- I'm interested
Presbyterian Kaseman Hospital
Albuquerque, New Mexico
- I'm interested
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico
- I'm interested
University of New Mexico Cancer Center
Albuquerque, New Mexico
- Call 631-638-7400
The Philips Family Cancer Center
Southampton, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 718-226-8888
Staten Island University Hospital
Staten Island, New York
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- I'm interested
Pluta Cancer Center
Rochester, New York
- Call 516-734-8896
Lenox Hill Hospital
New York, New York
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- Call 212-434-4460
Manhattan Eye Ear and Throat Hospital
New York, New York
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- I'm interested
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York
- Call 800-862-2215
Stony Brook University Medical Center
Stony Brook, New York
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- I'm interested
Montefiore Medical Center-Einstein Campus
The Bronx, New York
- Call 516-734-8896
Northwell Health Imbert Cancer Center
Bay Shore, New York
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- Call 718-765-2500
Maimonides Medical Center
Brooklyn, New York
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- I'm interested
NYU Langone Hospital - Brooklyn
Brooklyn, New York
- I'm interested
Roswell Park Cancer Institute
Buffalo, New York
- Call 315-472-7504
Hematology Oncology Associates of CNY at Camillus
Camillus, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 607-756-3130
Guthrie Cortland Memorial Hospital
Cortland, New York
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- Call 516-326-7514
Good Samaritan University Hospital
West Islip, New York
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- Call 845-483-6483
Vassar Brothers Medical Center
Poughkeepsie, New York
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- I'm interested
The Cancer Institute at Saint Francis Hospital
East Hills, New York
- Call 315-472-7504
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 516-734-8896
Northwell Health Cancer Institute at Huntington
Greenlawn, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 718-883-3000
Queens Hospital Center
Jamaica, New York
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- Call 516-734-8896
Northwell Health/Center for Advanced Medicine
Lake Success, New York
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- I'm interested
NYU Langone Hospital - Long Island
Mineola, New York
- I'm interested
Northern Westchester Hospital
Mount Kisco, New York
- I'm interested
Mount Sinai Chelsea
New York, New York
- I'm interested
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York
- I'm interested
Mount Sinai West
New York, New York
- I'm interested
Mount Sinai South Nassau
Oceanside, New York
- I'm interested
Mount Sinai Hospital
New York, New York
- Call 585-275-5830
University of Rochester
Rochester, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 914-366-1600
Phelps Memorial Hospital Center
Sleepy Hollow, New York
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- I'm interested
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina
- Call 336-713-6771
Wake Forest University Health Sciences
Winston-Salem, North Carolina
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- I'm interested
Novant Health Cancer Institute - Rowan
Salisbury, North Carolina
- I'm interested
Annie Penn Memorial Hospital
Reidsville, North Carolina
- I'm interested
UNC Health Cancer Care Wakefield
Raleigh, North Carolina
- I'm interested
UNC Health Cancer Care Raleigh
Raleigh, North Carolina
- I'm interested
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina
- I'm interested
Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina
- I'm interested
East Carolina University
Greenville, North Carolina
- Call 800-804-9376
Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina
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- I'm interested
Cone Health MedCenter Asheboro
Asheboro, North Carolina
- I'm interested
Duke Cancer Center Cary
Cary, North Carolina
- I'm interested
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina
- Call 800-804-9376
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina
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- I'm interested
Novant Health Presbyterian Medical Center
Charlotte, North Carolina
- Call 980-442-2000
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina
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- Call 980-442-2000
Levine Cancer Institute-SouthPark
Charlotte, North Carolina
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- Call 800-804-9376
Atrium Health University City/LCI-University
Charlotte, North Carolina
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- Call 888-716-9259
Wake Forest University at Clemmons
Clemmons, North Carolina
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- Call 800-804-9376
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina
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- Call 888-275-3853
Duke University Medical Center
Durham, North Carolina
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- Call 800-804-9376
Levine Cancer Institute - Rutherford
Forest City, North Carolina
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- Call 800-804-9376
Levine Cancer Institute-Gaston
Gastonia, North Carolina
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- I'm interested
Cone Health Cancer Center
Greensboro, North Carolina
- I'm interested
Cone Health Cancer Center at Drawbridge Parkway
Greensboro, North Carolina
- Call 980-442-2000
Levine Cancer Institute - Huntersville
Huntersville, North Carolina
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- I'm interested
Novant Health Cancer Institute - Huntersville
Huntersville, North Carolina
- I'm interested
Novant Health Cancer Institute - Kernersville
Kernersville, North Carolina
- Call 800-804-9376
Atrium Health Lincoln/LCI-Lincolnton
Lincolnton, North Carolina
This research site can be reached directly by phone. Call to ask about this study.
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- Call 980-442-0600
Levine Cancer Institute - Union West
Matthews, North Carolina
This research site can be reached directly by phone. Call to ask about this study.
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- Call 980-442-2000
Atrium Health Union/LCI-Union
Monroe, North Carolina
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- I'm interested
Novant Health Cancer Institute - Mooresville
Mooresville, North Carolina
- I'm interested
Novant Health Cancer Institute - Mount Airy
Mount Airy, North Carolina
- I'm interested
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina
- Call 919-785-4878
Duke Women's Cancer Care Raleigh
Raleigh, North Carolina
This research site can be reached directly by phone. Call to ask about this study.
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- Call 800-804-9376
Atrium Health Cleveland/LCI-Cleveland
Shelby, North Carolina
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- I'm interested
Novant Health Cancer Institute - Thomasville
Thomasville, North Carolina
- I'm interested
Novant Health Cancer Institute - Matthews
Matthews, North Carolina
- Call 800-804-9376
Levine Cancer Institute-Ballantyne
Charlotte, North Carolina
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Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota
- I'm interested
Sanford Bismarck Medical Center
Bismarck, North Dakota
- I'm interested
Sanford Roger Maris Cancer Center
Fargo, North Dakota
- I'm interested
Sanford Broadway Medical Center
Fargo, North Dakota
- I'm interested
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio
- Call 800-641-2422
UH Seidman Cancer Center at UH Avon Health Center
Avon, Ohio
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Summa Health System - Barberton Campus
Barberton, Ohio
- I'm interested
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio
- I'm interested
Strecker Cancer Center-Belpre
Belpre, Ohio
- I'm interested
Miami Valley Hospital South
Centerville, Ohio
- I'm interested
Adena Regional Medical Center
Chillicothe, Ohio
- I'm interested
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio
- I'm interested
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio
- I'm interested
Case Western Reserve University
Cleveland, Ohio
- I'm interested
Ohio State University Comprehensive Cancer Center
Columbus, Ohio
- I'm interested
Mount Carmel East Hospital
Columbus, Ohio
- I'm interested
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio
- I'm interested
Riverside Methodist Hospital
Columbus, Ohio
- I'm interested
Grant Medical Center
Columbus, Ohio
- I'm interested
The Mark H Zangmeister Center
Columbus, Ohio
- I'm interested
Doctors Hospital
Columbus, Ohio
- Call 937-276-8320
Premier Blood and Cancer Center
Dayton, Ohio
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Miami Valley Hospital North
Dayton, Ohio
- I'm interested
Delaware Health Center-Grady Cancer Center
Delaware, Ohio
- I'm interested
Grady Memorial Hospital
Delaware, Ohio
- I'm interested
Columbus Oncology and Hematology Associates
Dublin, Ohio
- I'm interested
Dublin Methodist Hospital
Dublin, Ohio
- I'm interested
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio
- Call 937-569-7515
Miami Valley Cancer Care and Infusion
Greenville, Ohio
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- I'm interested
Fairfield Medical Center
Lancaster, Ohio
- I'm interested
OhioHealth Mansfield Hospital
Mansfield, Ohio
- I'm interested
Memorial Hospital
Marysville, Ohio
- I'm interested
Summa Health Medina Medical Center
Medina, Ohio
- I'm interested
Licking Memorial Hospital
Newark, Ohio
- I'm interested
Mercy Health - Perrysburg Hospital
Perrysburg, Ohio
- I'm interested
OhioHealth Pickerington Methodist Hospital
Pickerington, Ohio
- I'm interested
Southern Ohio Medical Center
Portsmouth, Ohio
- I'm interested
Springfield Regional Cancer Center
Springfield, Ohio
- I'm interested
ProMedica Flower Hospital
Sylvania, Ohio
- I'm interested
Mercy Health - Saint Anne Hospital
Toledo, Ohio
- I'm interested
Upper Valley Medical Center
Troy, Ohio
- I'm interested
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio
- I'm interested
Saint Ann's Hospital
Westerville, Ohio
- I'm interested
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio
- I'm interested
Summa Health System - Akron Campus
Akron, Ohio
- I'm interested
OhioHealth Westerville Medical Campus/Westerville Cancer Center
Westerville, Ohio
- I'm interested
OhioHealth O'Bleness Hospital
Athens, Ohio
- I'm interested
Mount Carmel Grove City Hospital
Grove City, Ohio
- I'm interested
OhioHealth Marion General Hospital
Marion, Ohio
- Call 918-505-3200
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma
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- I'm interested
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
- Call 405-752-3402
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma
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- I'm interested
Kaiser Permanente Northwest
Portland, Oregon
- I'm interested
Oregon Health and Science University
Portland, Oregon
- I'm interested
Clackamas Radiation Oncology Center
Clackamas, Oregon
- I'm interested
Saint Charles Health System
Bend, Oregon
- Call 541-472-7000
Three Rivers Community Hospital
Grants Pass, Oregon
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- I'm interested
Asante Rogue Regional Medical Center
Medford, Oregon
- I'm interested
Providence Newberg Medical Center
Newberg, Oregon
- I'm interested
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon
- Call 503-413-2150
Legacy Mount Hood Medical Center
Gresham, Oregon
This research site can be reached directly by phone. Call to ask about this study.
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- Call 503-413-1742
Legacy Meridian Park Hospital
Tualatin, Oregon
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Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon
- I'm interested
Providence Willamette Falls Medical Center
Oregon City, Oregon
- I'm interested
Providence Saint Vincent Medical Center
Portland, Oregon
- I'm interested
Providence Portland Medical Center
Portland, Oregon
- I'm interested
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania
- I'm interested
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania
- Call 814-452-5000
Saint Vincent Hospital
Erie, Pennsylvania
This research site can be reached directly by phone. Call to ask about this study.
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- Call 717-721-4840
Ephrata Cancer Center
Ephrata, Pennsylvania
This research site can be reached directly by phone. Call to ask about this study.
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- Call 877-441-7957
WellSpan Health-York Cancer Center
York, Pennsylvania
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- I'm interested
Pocono Medical Center
East Stroudsburg, Pennsylvania
- I'm interested
Geisinger Medical Center
Danville, Pennsylvania
- I'm interested
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania
- I'm interested
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania
- Call 412-858-7746
Forbes Hospital
Monroeville, Pennsylvania
This research site can be reached directly by phone. Call to ask about this study.
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- Call 877-441-7957
Adams Cancer Center
Gettysburg, Pennsylvania
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- I'm interested
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania
- I'm interested
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania
- Call 717-217-6020
WellSpan Medical Oncology and Hematology
Chambersburg, Pennsylvania
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Wexford Health and Wellness Pavilion
Wexford, Pennsylvania
- Call 610-988-9323
Reading Hospital
West Reading, Pennsylvania
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- I'm interested
Community Medical Center
Scranton, Pennsylvania
- Call 800-836-0388
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania
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- I'm interested
Penn State Health Saint Joseph Medical Center
Reading, Pennsylvania
- Call 877-284-2000
Allegheny General Hospital
Pittsburgh, Pennsylvania
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Jefferson Torresdale Hospital
Philadelphia, Pennsylvania
- I'm interested
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania
- I'm interested
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania
- I'm interested
Sechler Family Cancer Center
Lebanon, Pennsylvania
- I'm interested
Jefferson Hospital
Jefferson Hills, Pennsylvania
- I'm interested
Geisinger Cancer Center Dickson City
Dickson City, Pennsylvania
- I'm interested
Yolanda G Barco Oncology Institute
Meadville, Pennsylvania
- I'm interested
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania
- Call 401-444-1488
Rhode Island Hospital
Providence, Rhode Island
This research site can be reached directly by phone. Call to ask about this study.
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- Call 401-274-1122
Women and Infants Hospital
Providence, Rhode Island
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- I'm interested
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island
- I'm interested
Medical University of South Carolina
Charleston, South Carolina
- I'm interested
Lexington Medical Center
West Columbia, South Carolina
- I'm interested
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina
- Call 800-804-9376
Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Prisma Health Cancer Institute - Greer
Greer, South Carolina
- I'm interested
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina
- I'm interested
Prisma Health Cancer Institute - Faris
Greenville, South Carolina
- I'm interested
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina
- I'm interested
Saint Francis Cancer Center
Greenville, South Carolina
- I'm interested
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina
- I'm interested
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina
- I'm interested
Prisma Health Cancer Institute - Easley
Easley, South Carolina
- I'm interested
McLeod Regional Medical Center
Florence, South Carolina
- I'm interested
Saint Francis Hospital
Greenville, South Carolina
- I'm interested
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina
- I'm interested
Self Regional Healthcare
Greenwood, South Carolina
- I'm interested
South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina
- I'm interested
Avera Cancer Institute at Yankton
Yankton, South Dakota
- I'm interested
Avera Cancer Institute - Mitchell
Mitchell, South Dakota
- I'm interested
Avera Cancer Institute at Pierre
Pierre, South Dakota
- I'm interested
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota
- I'm interested
Avera Cancer Institute
Sioux Falls, South Dakota
- I'm interested
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota
- I'm interested
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota
- Call 800-811-8480
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee
This research site can be reached directly by phone. Call to ask about this study.
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- Call 865-544-9773
University of Tennessee - Knoxville
Knoxville, Tennessee
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- I'm interested
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee
- I'm interested
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee
- Call 800-811-8480
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Methodist Willowbrook Hospital
Houston, Texas
- I'm interested
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas
- Call 713.790.3311
Houston Methodist Hospital
Houston, Texas
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Houston Methodist The Woodlands Hospital
The Woodlands, Texas
- Call 254-724-5407
Scott and White Memorial Hospital
Temple, Texas
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- Call 281.274.7000
Houston Methodist Sugar Land Hospital
Sugar Land, Texas
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- I'm interested
UT MD Anderson - Sugar Land
Sugar Land, Texas
- I'm interested
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas
- I'm interested
Houston Methodist Saint John Hospital
Nassau Bay, Texas
- I'm interested
UT MD Anderson - League City
League City, Texas
- Call 832.522.6070
Houston Methodist West Hospital
Houston, Texas
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- I'm interested
UT MD Anderson - West Houston
Houston, Texas
- I'm interested
Houston Methodist San Jacinto Hospital
Baytown, Texas
- I'm interested
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas
- I'm interested
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas
- I'm interested
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas
- Call 713-566-5000
Lyndon Baines Johnson General Hospital
Houston, Texas
This research site can be reached directly by phone. Call to ask about this study.
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- Call 713-873-2000
Ben Taub General Hospital
Houston, Texas
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- I'm interested
Parkland Memorial Hospital
Dallas, Texas
- I'm interested
Houston Methodist Cypress Hospital
Cypress, Texas
- I'm interested
UT MD Anderson - The Woodlands
Conroe, Texas
- I'm interested
South Jordan Health Center
South Jordan, Utah
- I'm interested
University of Utah Sugarhouse Health Center
Salt Lake City, Utah
- I'm interested
Farmington Health Center
Farmington, Utah
- I'm interested
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah
- I'm interested
University of Vermont Medical Center
Burlington, Vermont
- Call 802-225-5400
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont
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- I'm interested
University of Vermont and State Agricultural College
Burlington, Vermont
- I'm interested
VCU Massey Cancer Center at Stony Point
Richmond, Virginia
- I'm interested
Inova Schar Cancer Institute
Fairfax, Virginia
- I'm interested
Inova Fair Oaks Hospital
Fairfax, Virginia
- I'm interested
Inova Fairfax Hospital
Falls Church, Virginia
- Call 540-332-5960
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia
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- I'm interested
Centra Alan B Pearson Regional Cancer Center
Lynchburg, Virginia
- I'm interested
Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia
- I'm interested
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia
- I'm interested
Bon Secours Saint Francis Medical Center
Midlothian, Virginia
- I'm interested
Bon Secours Saint Mary's Hospital
Richmond, Virginia
- I'm interested
VCU Massey Comprehensive Cancer Center
Richmond, Virginia
- I'm interested
Kaiser Permanente-Caton Hill Medical Center
Woodbridge, Virginia
- Call 425-454-2148
FHCC Overlake
Bellevue, Washington
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- I'm interested
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington
- Call 425-899-6000
FHCC at EvergreenHealth
Kirkland, Washington
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Kadlec Clinic Hematology and Oncology
Kennewick, Washington
- I'm interested
Swedish Cancer Institute-Issaquah
Issaquah, Washington
- I'm interested
Swedish Cancer Institute-Edmonds
Edmonds, Washington
- I'm interested
Swedish Medical Center-First Hill
Seattle, Washington
- Call 206-606-5800
FHCC at Northwest Hospital
Seattle, Washington
This research site can be reached directly by phone. Call to ask about this study.
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- Call 503-413-2150
Legacy Salmon Creek Hospital
Vancouver, Washington
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- I'm interested
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington
- Call 800-804-8824
University of Washington Medical Center - Montlake
Seattle, Washington
This research site can be reached directly by phone. Call to ask about this study.
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- Call 800-804-8824
Fred Hutchinson Cancer Center
Seattle, Washington
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- I'm interested
Valley Medical Center
Renton, Washington
- I'm interested
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington
- I'm interested
West Virginia University Healthcare
Morgantown, West Virginia
- I'm interested
Edwards Comprehensive Cancer Center
Huntington, West Virginia
- I'm interested
United Hospital Center
Bridgeport, West Virginia
- I'm interested
Camden Clark Medical Center
Parkersburg, West Virginia
- Call 304-487-7515
Princeton Community Hospital
Princeton, West Virginia
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Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin
- I'm interested
Aurora Cancer Care-Racine
Racine, Wisconsin
- I'm interested
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin
- I'm interested
ThedaCare Cancer Care - Oshkosh
Oshkosh, Wisconsin
- I'm interested
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
Oshkosh, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin
- Call 262-928-7878
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin
This research site can be reached directly by phone. Call to ask about this study.
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- Call 414-805-0505
Drexel Town Square Health Center
Oak Creek, Wisconsin
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ThedaCare Cancer Care - New London
New London, Wisconsin
- I'm interested
ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin
- I'm interested
ProHealth D N Greenwald Center
Mukwonago, Wisconsin
- I'm interested
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin
- I'm interested
Aurora Sinai Medical Center
Milwaukee, Wisconsin
- Call 414-805-3666
Medical College of Wisconsin
Milwaukee, Wisconsin
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Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin
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Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
Milwaukee, Wisconsin
- I'm interested
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin
- I'm interested
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
Mequon, Wisconsin
- Call 262-257-5100
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin
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Aspirus Medford Hospital
Medford, Wisconsin
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Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin
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Marshfield Medical Center-Marshfield
Marshfield, Wisconsin
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Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin
- I'm interested
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin
- I'm interested
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin
- I'm interested
Gundersen Lutheran Medical Center
La Crosse, Wisconsin
- I'm interested
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin
- I'm interested
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin
- I'm interested
Aurora Cancer Care-Grafton
Grafton, Wisconsin
- I'm interested
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin
- I'm interested
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
Franklin, Wisconsin
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Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin
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Ascension Calumet Hospital-Chilton
Chilton, Wisconsin
- I'm interested
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin
- I'm interested
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
Brookfield, Wisconsin
- I'm interested
ThedaCare Cancer Care - Berlin
Berlin, Wisconsin
- I'm interested
Duluth Clinic Ashland
Ashland, Wisconsin
- I'm interested
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
Appleton, Wisconsin
- I'm interested
ThedaCare Regional Cancer Center
Appleton, Wisconsin
- I'm interested
Aspirus Cancer Care-Antigo-Volm Cancer Center
Antigo, Wisconsin
- I'm interested
Aurora BayCare Medical Center
Green Bay, Wisconsin
- I'm interested
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
Rhinelander, Wisconsin
- I'm interested
Aurora Health Care Germantown Health Center
Germantown, Wisconsin
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Ascension All Saints Hospital-Spring Street-Racine
Racine, Wisconsin
- Call 715-422-7718
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin
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Marshfield Medical Center - Weston
Weston, Wisconsin
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Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin
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Aurora West Allis Medical Center
West Allis, Wisconsin
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Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin
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Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
Wauwatosa, Wisconsin
- Call 877-405-6866
Aspirus Cancer Care-Wausau
Wausau, Wisconsin
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ThedaCare Cancer Care - Waupaca
Waupaca, Wisconsin
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UW Cancer Center at ProHealth Care
Waukesha, Wisconsin
- I'm interested
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin
- I'm interested
Aurora Medical Center in Summit
Summit, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin
- I'm interested
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin
- I'm interested
Essentia Health-Spooner Clinic
Spooner, Wisconsin
- I'm interested
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin
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Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin
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ThedaCare Cancer Care - Shawano
Shawano, Wisconsin
Who can participate
Inclusion criteria
- ✓Age \>= 18 years
- ✓Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
- ✓Triple Negative Breast Cancer:
- ✓Patients with a history of clinical stage T1cN1-2 or T2-4N0-2 (clinical stage II or III prior to preoperative therapy) breast cancer at time of diagnosis according to the primary tumor-regional lymph node anatomic staging criteria of the American Joint Committee on Cancer (AJCC), 8th edition as determined by the investigator in radiologic assessment, clinical assessment or both
- ✓Patients must have no residual invasive disease in the breast or lymph nodes after the completion of neoadjuvant therapy. Residual ductal carcinoma in situ (DCIS) is allowed. Isolated tumor cells are considered node-negative
- ✓Estrogen receptor (ER) and progesterone receptor (PR) =\< 10%; HER2-negative by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines (immunohistochemistry \[IHC\] and fluorescence in situ hybridization \[FISH\])
- ✓If invasive disease was present in both breasts, participation in the study is permitted as long as the eligibility criteria are met for both tumors/breasts
- ✓Patients must have received neoadjuvant chemotherapy in combination with pembrolizumab for a minimum of 6 cycles. All systemic chemotherapy must have been completed preoperatively
- ✓An interval of no more than 12 weeks between the completion date of the final surgery and the date of randomization
- ✓\* Note: Adjuvant radiation can be given on study, however, it is recommended to complete adjuvant radiation prior to registration. If radiation is given on study, it is encouraged to be given concurrently with pembrolizumab if the patient is on the pembrolizumab arm, per investigator discretion. Treatment with adjuvant pembrolizumab is strongly discouraged prior to participation in this trial, but if administered (e.g., if patients are awaiting pathology results), pembrolizumab may be administered for up to 6 weeks (i.e., up to 2 q3week doses or up to one q6week dose) post-surgery and must be completed prior to registration post-surgery and must be completed prior to registration
- ✓Use of investigational anti-cancer agents must be discontinued at time of registration
- ✓Adequate excision: Surgical removal of all clinically evident disease in the breast and lymph nodes as follows:
- ✓Breast surgery: Total mastectomy or breast-conserving surgery with histologically negative margins, including no ink on tumor for DCIS, at the time of excision
- ✓\*\* For patients who undergo breast-conserving surgery, the margins of the resected specimen must be histologically free of ductal carcinoma in-situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates DCIS at the line of resection, additional operative procedures may be performed to obtain clear margins. If DCIS is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. Patients with margins positive for classic lobular carcinoma in situ (LCIS) are eligible without additional resection
- ✓Lymph node surgery:
- ✓For a patient with clinically N0 disease, a sentinel lymph node biopsy should have been performed at time of surgical evaluation, and if pathologically node positive, the patient is no longer eligible. Isolated tumor cells are considered node-negative
- ✓For a patient with clinically N1 disease at diagnosis (with positive results from a fine-needle aspiration, core biopsy, or sentinel node biopsy performed prior to preoperative therapy) additional surgical evaluation of the axilla following preoperative therapy is required
- ✓\*\*\* If they become cN0 (no palpable adenopathy), then a sentinel lymph node biopsy could have been performed at time of surgery (axillary dissection would also be permitted); if the sentinel lymph node biopsy is positive, the patient is no longer eligible
- ✓If sentinel node biopsy performed before preoperative therapy was negative, no additional surgical evaluation of the axilla is required after preoperative therapy. If sentinel node biopsy performed before preoperative therapy was positive, an ALND is required after preoperative therapy
- ✓If the only sentinel node identified by isotope scan is in the internal mammary chain, surgical evaluation of the axilla is still required
- ✓If sentinel node evaluation after preoperative therapy is negative, no further additional surgical evaluation of the axilla is required
- ✓Axillary dissection without sentinel node evaluation is permitted as the initial or sole axillary evaluation after preoperative therapy
- ✓If breast-conserving surgery was performed but patient will not be receiving breast radiation, the patient is not eligible
- ✓Not pregnant and not nursing, because this study involves an agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =\< 7 days prior to randomization is required
- ✓Absolute neutrophil count (ANC) \>= 1,000/mm\^3
- ✓Platelet Count \>= 100,000/mm\^3
- ✓Estimated glomerular filtration rate (eGFR) \>= 15 mL/min/1.73m\^2
- ✓Total Bilirubin =\<1.5 x upper limit of normal (ULN)
- ✓\* Patients with Gilbert's disease with a total bilirubin =\< 2.5 x ULN and direct bilirubin within normal limits are permitted
- ✓Aspartate aminotransferase (AST) serum aspartate aminotransferase \[SGOT\] / alanine aminotransferase (ALT) serum glutamic pyruvic transaminase \[SGPT\] =\< 3 x institutional ULN
- ✓Patients must be willing to provide tumor tissue from the diagnostic core biopsy. If inadequate tumor tissue is available, patients are still eligible to participate in the trial
- ✓Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- ✓Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
- ✓Patients with known HIV infection who are on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial
Exclusion criteria
- ✕No stage IV (metastatic) breast cancer
- ✕No history of any prior (ipsi- or contralateral) invasive breast cancer. Prior DCIS is allowed
- ✕No evidence of recurrent disease following preoperative therapy and surgery
- ✕No known active liver disease, e.g. due to hepatitis B virus (HBV), hepatitis C virus (HCV), autoimmune hepatic disorders, or sclerosing cholangitis
- ✕No history of intolerance, including Grade 3 or 4 infusion reaction or hypersensitivity to pembrolizumab or murine proteins or any components of the product
- ✕\* Note: Prior immune-related adverse events (irAEs) are allowed if they resolved to ≤ grade 1 and the patient tolerated subsequent therapy without requiring chronic steroids for the irAE. The following are exceptions to this criterion: Grade 2 or lower immune mediated endocrinopathies due to neoadjuvant checkpoint inhibition but patients are stable on endocrine therapy and were able to continue checkpoint inhibition.
- ✕No medical conditions that require chronic systemic steroids (\>10 mg prednisone daily or equivalent) or any other form of immunosuppressive medications and has required such therapy in the last two years. Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic therapy
- ✕Patients who are unable or unwilling to comply with the requirements of the protocol per investigator assessment are not eligible
Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.
Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.