Phenotyping Genetic Risk for Type 2 Diabetes
Sponsored by University of Pennsylvania
About this study
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment.
Where this study is enrolling (2)
- I'm interested
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania
- I'm interested
University of Pennsylvania
Philadelphia, Pennsylvania
Who can participate
Inclusion criteria
- ✓Age 10-70 years
- ✓Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
- ✓Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
Exclusion criteria
- ✕prior diagnosis of type 1, type 2, or secondary diabetes
- ✕use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
- ✕acute illness that may impact insulin and glucose dynamics
- ✕pregnancy
- ✕hypothalamic obesity or related genetic disorder of metabolism
- ✕recent systemic chemotherapy use
- ✕gastrointestinal impairment or surgery that may impact absorption
- ✕anemia
- ✕major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
- ✕inability to comply with study protocol
Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.
Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.