Phosphorylated Tau Levels in Donated Blood
Sponsored by The University of Texas Health Science Center, Houston
About this study
Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk. Recent studies suggest that individuals with elevated pTau217 levels may be at increased risk for developing AD and cognitive dysfunction. This observational study will examine donated human plasma samples to determine whether some units of donated blood contain abnormally elevated pTau217 concentrations. The overarching goal is to evaluate whether transfusion of blood with higher pTau217 may pose risks to recipients and whether such units should be avoided in clinical use.
Study Type: Observational (Laboratory-based biomarker study; no human intervention) Study Design: * Model: Cross-sectional * Time Perspective: Prospective * Sample Source: Donated human blood plasma samples obtained through a blood bank * Enrollment: \~250 plasma samples; \~20 plasma samples of AD patients and \~20 plasma samples of normal control participants, where are purchased from BioIVT (Westbury, NY, USA). Official Title: Observational Measurement of pTau217 in Donated Human Plasma Samples Primary Objective: To determine the prevalence of elevated plasma pTau217 levels in donated blood. Secondary Objectives: 1. To compare pTau217 concentrations with total Tau to assess biomarker distribution in donated blood. 2. To generate preliminary data on whether pTau217 screening coul…
Where this study is enrolling
- I'm interested
University of Texas Health Science Center at Houston
Houston, Texas
Who can participate
Inclusion criteria
- ✓The plasma sample from donators.
Exclusion criteria
- ✕None.
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Trial data sourced from ClinicalTrials.gov.