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Early Phase 1Recruiting

R01.Aim 2.Study 1: IsoReach

Sponsored by Shirley Ryan AbilityLab

About this study

To determine the effects of 3D isometric movement training in healthy participants and impaired participants due to a stroke.

Researchers have found that neurotypical adults are able to train movement skills when sensory sources, such as proprioception, are altered using isometric conditions and visual feedback in a two-dimensional environment.Building off this knowledge, the investigators plan to apply similar techniques to both neurotypical adults and stroke survivors with impaired movement, but in a three-dimensional environment. The investigators will ask participants to practice a unilateral virtual reality targeted reaching task using a robotic arm in a 3D visual display system mounted over the arm. Participants will be given visual feedback of their arm through a virtual avatar displayed on the screen. First, they will complete unconstrained targeted reaching and then complete targeted reaching with the ro…

Where this study is enrolling

Who can participate

Inclusion criteria

  • ✓, neurotypical participants
  • ✓18 years old
  • ✓No history of stroke
  • ✓Ability to provide informed consent .

Exclusion criteria

  • ✕, neurotypical participants
  • ✕Severe medical problems (including cardiovascular, orthopedic, or neurological)
  • ✕Medical problems affecting movement, range of motion, strength, or coordination of the upper extremities.
  • ✕Visual deficits that would influence the ability to perform the experiment . This will be assessed using the following assessments:
  • ✕1. Visual field deficits will be assessed using the BIVABA acuity testing. (cutoff score \> 20/100)
  • ✕2. Depth perception deficits will be assessed using the Stereofly test (require at least an angle of stereopsis at 16 inches is 3,552 seconds of arc).
  • ✕4\) Blood pressure above 140 systolic and/or 90 diastolic mmHG
  • ✕5\) Blood oxygen reading of less than 92% by finger pulse oximeter testing.
  • ✕Inclusion Criteria , Stroke participants
  • ✕18 years old
  • ✕Chronic stroke (8+ months post)
  • ✕Available medical records and radiographic information about lesion locations
  • ✕Hemiparesis
  • ✕Primary motor cortex involvement
  • ✕Some degree of both shoulder and elbow movement capability
  • ✕Exclusion Criteria , Stroke participants
  • ✕Bilateral paresis
  • ✕Aphasia, cognitive impairment, or affective dysfunction that would influence the ability to perform the experiment, This will be assessed using the Mini Mental State Examination31, with cut-off scores (adjusted for education level) as follows:
  • ✕Participants whose education are 7th grade or lower, a score 22 or lower
  • ✕Participants whose education attainment level is 8th grade or some high school (but not a graduate), a score of 24 or lower
  • ✕Participants whose education attainment level is high school graduate, a score of 25 or lower
  • ✕Participants whose education attainment level is some college or higher, a score 26 or lower
  • ✕Visual deficits, and hemispatial neglect that would prevent the participants from seeing the targets. A vision test will be done if the participant indicates in their screen that their stroke has affected their vision. This will be tested using the following assessments:
  • ✕Visual field loss will be assessed using the BIVABA acuity test10. (cutoff score \> 20/100)
  • ✕Visual Extinction and Inattention using Star Cancellation Test9. (cutoff score of \<44)
  • ✕Depth perception deficits will be assessed using the Stereofly test (require at least an angle of stereopsis at 16 inches is 3,552 seconds of arc).
  • ✕Modified Ashworth score of 4 at shoulder or elbow joints.
  • ✕Rated below 15 on the FMUE scale
  • ✕Inability to provide an informed consent
  • ✕severe current medical problems
  • ✕Severe sensory deficit in the affected limb (Cannot be absent in any part of affected UE)
  • ✕diffuse/multiple lesion sites or multiple stroke events
  • ✕Inability to attain and maintain testing positions
  • ✕Botox or other botulinum toxin injection to the affected upper extremity within the previous 4 months
  • ✕Concurrent participation in upper extremity rehabilitation either as part of a research intervention protocol or a prescribed therapy
  • ✕Neurological, neuromuscular, or orthopedic diseases (i.e. injuries to your affected arm or hand)
  • ✕Other neurological issues (Parkinson's, CP)
  • ✕Blood Pressure above 140 systolic and/or 90 diastolic mmHg
  • ✕Blood oxygen reading of less than 92% on finger pulse oximetry testing.

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Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.