Reverse Remodeling of the Pulmonary Vasculature: a Longitudinal, Investigational Study of the Effects of Sotatercept.
Sponsored by Franz Rischard, DO
About this study
The goal of this study is to learn more about how sotatercept works and if it helps the lung arteries become healthier. Sotatercept will be associated with the following: 1. Improvement in capillary blush, reduce the tapering and tortuosity of affected vessels on pulmonary wedge angiography and decreased wall thickness on intravascular ultrasound in previously affected areas. 2. Improvement in previously poorly or non-perfused areas rather than increased perfusion to previously perfused areas. 3. No changes in baseline ventilation and improvement and ventilation/perfusion matching.
Where this study is enrolling
- I'm interested
The Clinical and Translational Sciences Research Center
Tucson, Arizona
Who can participate
Inclusion criteria
- ✓Feasibility Group:
- ✓Group 1 Pulmonary Hypertension (G1PH)-must be idiopathic, drug induced, or hereditary (D/H/I)
- ✓Age \< 65 years at time of diagnosis
- ✓Must be 18 years of age or older
- ✓Inclusion Criteria - "Real-world" treatment naïve cohort:
- ✓Group 1 Pulmonary Hypertension (G1PH)-all types
- ✓Must be treatment naïve
- ✓Must be 18 years of age or older
- ✓Inclusion Criteria - "Real-world" prevalent cohort:
- ✓Group 1 Pulmonary Hypertension (G1PH)-all types
- ✓Must be 18 years of age or older
Exclusion criteria
- ✕Contraindication to right heart catheterization (per PI)
- ✕Prior exposure to sotatercept
- ✕Hemoglobin \> 18 g/dL at screening
- ✕Estimated GFR \< 30 mL/min at screening
- ✕Platelet count \<30 at screening
- ✕Positive pregnancy test
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Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.