RISE: Reducing Cancer and HIV Stigma Through Empowerment
Sponsored by M.D. Anderson Cancer Center
About this study
This multilevel randomized behavioral study evaluates participant- and provider-level stigma-reduction interventions in Zambia. Participant-level intervention: Women living with cervical cancer and HIV (WLC+H ) are randomized in a 2×2 factorial design of storytelling versus neutral videos and storytelling versus neutral disclosure interventions to assess effects on quality of life, anxiety, and depressive symptoms. Provider-level intervention: Healthcare workers are randomized to storytelling or neutral videos to assess changes in stigma and compassion. The study also evaluates participant -reported stigma and satisfaction with care before and after implementation of the provider intervention.
People living with HIV face a substantially elevated risk of developing cancers due to compromised immunity. Among women, HIV significantly increases vulnerability to oncogenic human papillomavirus (HPV) infection, the primary cause of cervical cancer. This dual burden of cervical cancer and HIV disproportionately impacts low- and middle-income countries (LMICs), with Zambia exemplifying this crisis. Outcomes for affected individuals living with cervical cancer and HIV in LMICs are poor, with a one-year survival rate of just 65%. Addressing this intertwined public health challenge in LMICs is critical to advancing global efforts against cancer and HIV. This study uses a multilevel approach to address intersectional stigma at the patient and provider level. In the participant -level compon…
Where this study is enrolling
- I'm interested
UT MD Anderson
Houston, Texas
Who can participate
Inclusion criteria
- ✓Patient-level intervention
- ✓1. Women diagnosed with cervical cancer and HIV (stage I-IV)
- ✓2. Receiving cancer treatment at the Cancer Disease Hospital in Zambia
- ✓3. Aged 18 or above 4. Able to speak in English (the official language in Zambia) or one of four local languages (Bemba, Nyanja, Tonga, Lozi) for cultural inclusivity
- ✓Provider-level intervention
- ✓1\. Employment at the Cancer Disease Hospital in Lusaka, Zambia
Exclusion criteria
- ✕Patient-level intervention
- ✕1.Inability to provide informed consent and presence of a major mental health disorder (e.g., schizophrenia or bipolar disorder), as determined by participant records or self-report.
- ✕Provider-level intervention
- ✕1\. Inability to provide informed consent
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Trial data sourced from ClinicalTrials.gov.