S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Sponsored by SWOG Cancer Research Network
About this study
This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual approach to monitoring disease.
PRIMARY OBJECTIVES: I. To assess whether patients with HER-2 negative, hormone receptor positive, metastatic breast cancer who are monitored with serum tumor marker directed disease monitoring (STMDDM) have non-inferior overall survival compared to patients monitored with usual care. SECONDARY OBJECTIVES: I. To compare cumulative direct healthcare costs through 48 weeks among patients monitored with STMDDM versus those monitored with usual care in this patient population. II. To assess whether the patient-reported outcomes (PROs) of anxiety and quality of life (QOL) are different among patients who are monitored with STMDDM compared with patients who are monitored with usual care in this patient population. TERTIARY OBJECTIVES: I. To assess modality and frequency of disease monitorin…
Where this study is enrolling (586)
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Anchorage Oncology Centre
Anchorage, Alaska
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Alaska Breast Care and Surgery LLC
Anchorage, Alaska
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Anchorage Associates in Radiation Medicine
Anchorage, Alaska
- I'm interested
Katmai Oncology Group
Anchorage, Alaska
- I'm interested
Alaska Women's Cancer Care
Anchorage, Alaska
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Fairbanks Memorial Hospital
Fairbanks, Alaska
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Providence Alaska Medical Center
Anchorage, Alaska
- I'm interested
Anchorage Radiation Therapy Center
Anchorage, Alaska
- I'm interested
Alaska Oncology and Hematology LLC
Anchorage, Alaska
- I'm interested
Banner University Medical Center - Tucson
Tucson, Arizona
- Call 520-694-8900
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona
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University of Arizona Cancer Center-North Campus
Tucson, Arizona
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Cancer Center at Saint Joseph's
Phoenix, Arizona
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Kingman Regional Medical Center
Kingman, Arizona
- I'm interested
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas
- Call 800-378-9373
Mercy Hospital Fort Smith
Fort Smith, Arkansas
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- Call 501-686-8274
University of Arkansas for Medical Sciences
Little Rock, Arkansas
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Epic Care Cyberknife Center
Walnut Creek, California
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Kaiser Permanente-Woodland Hills
Woodland Hills, California
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Kaiser Permanente-San Marcos
San Marcos, California
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Kaiser Permanente-San Diego Zion
San Diego, California
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Kaiser Permanente-San Diego Mission
San Diego, California
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Mercy Cancer Center �� Carmichael
Carmichael, California
- Call 510-835-9900
Bay Area Breast Surgeons Inc
Emeryville, California
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- Call 707-521-3830
Providence Santa Rosa Memorial Hospital
Santa Rosa, California
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Bay Area Tumor Institute
Oakland, California
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Mercy Cancer Center - Rocklin
Rocklin, California
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Mercy Cancer Center - Sacramento
Sacramento, California
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Mission Hope Medical Oncology - Santa Maria
Santa Maria, California
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Marshall Cancer Center
Cameron Park, California
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Woodland Memorial Hospital
Woodland, California
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Mercy Cancer Center - Elk Grove
Elk Grove, California
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Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California
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Kaiser Permanente-Riverside
Riverside, California
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Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California
- Call 925-957-5400
Contra Costa Regional Medical Center
Martinez, California
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Kaiser Permanente - Panorama City
Panorama City, California
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Kaiser Permanente Los Angeles Medical Center
Los Angeles, California
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Kaiser Permanente-Ontario
Ontario, California
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Kaiser Permanente-Irvine
Irvine, California
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Kaiser Permanente-Fontana
Fontana, California
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Kaiser Permanente West Los Angeles
Los Angeles, California
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Kaiser Permanente-Bellflower
Bellflower, California
- Call 707-521-3830
Providence Queen of The Valley
Napa, California
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Kaiser Permanente-Anaheim
Anaheim, California
- Call 707-521-3830
Providence Medical Foundation - Santa Rosa
Santa Rosa, California
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PCR Oncology
Arroyo Grande, California
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Kaiser Permanente-Baldwin Park
Baldwin Park, California
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Mercy San Juan Medical Center
Carmichael, California
- Call 925-875-1677
Epic Care-Dublin
Dublin, California
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Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California
- Call 510-629-6682
Epic Care Partners in Cancer Care
Emeryville, California
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Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado
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National Jewish Health-Western Hematology Oncology
Golden, Colorado
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Porter Adventist Hospital
Denver, Colorado
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Penrose-Saint Francis Healthcare
Colorado Springs, Colorado
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Parker Adventist Hospital
Parker, Colorado
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The Women's Imaging Center
Denver, Colorado
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The Melanoma and Skin Cancer Institute
Englewood, Colorado
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Swedish Medical Center
Englewood, Colorado
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Boulder Community Foothills Hospital
Boulder, Colorado
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Boulder Community Hospital
Boulder, Colorado
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Mercy Medical Center
Durango, Colorado
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Southwest Oncology PC
Durango, Colorado
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Littleton Adventist Hospital
Littleton, Colorado
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Longmont United Hospital
Longmont, Colorado
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Colorado Blood Cancer Institute
Denver, Colorado
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Saint Mary Corwin Medical Center
Pueblo, Colorado
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Saint Francis Cancer Center
Colorado Springs, Colorado
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Saint Anthony Hospital
Lakewood, Colorado
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Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado
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Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado
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Rocky Mountain Cancer Centers-Rose
Denver, Colorado
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Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado
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Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado
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Rocky Mountain Cancer Centers-Midtown
Denver, Colorado
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National Jewish Health-Main Campus
Denver, Colorado
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Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado
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Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado
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Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado
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Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado
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Rocky Mountain Cancer Centers - Swedish
Englewood, Colorado
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Rocky Mountain Cancer Centers - Centennial
Centennial, Colorado
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National Jewish Health-Northern Hematology Oncology
Thornton, Colorado
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Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut
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Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut
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Yale University
New Haven, Connecticut
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Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut
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Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut
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Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut
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Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut
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Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut
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Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut
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Sacred Heart Hospital
Pensacola, Florida
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Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida
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Mount Sinai Medical Center
Miami Beach, Florida
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Cleveland Clinic-Weston
Weston, Florida
- Call 954-267-7748
Holy Cross Hospital
Fort Lauderdale, Florida
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- Call 863-680-7780
The Watson Clinic
Lakeland, Florida
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Grady Health System
Atlanta, Georgia
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Emory Saint Joseph's Hospital
Atlanta, Georgia
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Emory University Hospital Midtown
Atlanta, Georgia
- I'm interested
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia
- I'm interested
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia
- Call 808-532-0315
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii
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- Call 808-535-7960
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii
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- Call 808-547-9816
Kuakini Medical Center
Honolulu, Hawaii
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- Call 808-547-6881
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii
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- Call 808-678-9000
The Cancer Center of Hawaii-Pali Momi
‘Aiea, Hawaii
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Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii
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The Queen's Medical Center - West Oahu
‘Ewa Beach, Hawaii
- Call 808-983-6090
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii
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Hawaii Diagnostic Radiology Services LLC
Honolulu, Hawaii
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Hawaii Cancer Care - Westridge
‘Aiea, Hawaii
- Call 808-586-2979
University of Hawaii Cancer Center
Honolulu, Hawaii
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- Call 808-486-6000
Pali Momi Medical Center
‘Aiea, Hawaii
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Castle Medical Center
Kailua, Hawaii
- Call 808-522-4333
Straub Clinic and Hospital
Honolulu, Hawaii
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- Call 808-545-8548
Queen's Medical Center
Honolulu, Hawaii
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- Call 808-487-7447
Queen's Cancer Center - Pearlridge
‘Aiea, Hawaii
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- Call 808-531-8521
Queen's Cancer Center - Kuakini
Honolulu, Hawaii
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Straub Medical Center - Kahului Clinic
Kahului, Hawaii
- Call 808-522-4333
Straub Pearlridge Clinic
‘Aiea, Hawaii
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Saint Luke's Cancer Institute - Boise
Boise, Idaho
- I'm interested
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho
- I'm interested
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho
- I'm interested
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho
- I'm interested
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho
- I'm interested
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho
- I'm interested
Kootenai Cancer Clinic
Sandpoint, Idaho
- I'm interested
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho
- I'm interested
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho
- I'm interested
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho
- I'm interested
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho
- I'm interested
Walter Knox Memorial Hospital
Emmett, Idaho
- I'm interested
Idaho Urologic Institute-Meridian
Meridian, Idaho
- Call 800-444-7541
Springfield Clinic
Springfield, Illinois
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Memorial Medical Center
Springfield, Illinois
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Memorial Hospital of Carbondale
Carbondale, Illinois
- Call 708-216-9000
Loyola Center for Health at Burr Ridge
Burr Ridge, Illinois
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- Call 708-216-9000
Loyola Medicine Homer Glen
Homer Glen, Illinois
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- Call 708-226-4357
Loyola University Medical Center
Maywood, Illinois
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- Call 708-450-4554
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois
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- Call 309-779-2000
Trinity Medical Center
Moline, Illinois
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The Carle Foundation Hospital
Urbana, Illinois
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Cancer Care Center of O'Fallon
O'Fallon, Illinois
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Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois
- I'm interested
Carle at The Riverfront
Danville, Illinois
- I'm interested
Carle Cancer Center
Urbana, Illinois
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Carle Physician Group-Effingham
Effingham, Illinois
- I'm interested
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois
- Call 217-545-7929
Southern Illinois University School of Medicine
Springfield, Illinois
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Centralia Oncology Clinic
Centralia, Illinois
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SIH Cancer Institute
Carterville, Illinois
- I'm interested
Saint Mary's Hospital
Centralia, Illinois
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Crossroads Cancer Center
Effingham, Illinois
- I'm interested
Decatur Memorial Hospital
Decatur, Illinois
- Call 618-463-5623
Saint Anthony's Health
Alton, Illinois
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Rush-Copley Healthcare Center
Yorkville, Illinois
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Rush - Copley Medical Center
Aurora, Illinois
- Call 309-344-2831
Western Illinois Cancer Treatment Center
Galesburg, Illinois
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West Suburban Medical Center
River Forest, Illinois
- Call 618-242-4600
Good Samaritan Regional Health Center
Mount Vernon, Illinois
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- Call 815-664-4141
Valley Radiation Oncology
Peru, Illinois
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Illinois CancerCare - Washington
Washington, Illinois
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Illinois CancerCare-Bloomington
Bloomington, Illinois
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Illinois CancerCare-Canton
Canton, Illinois
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Illinois CancerCare-Carthage
Carthage, Illinois
- Call 815-285-7800
Illinois CancerCare-Dixon
Dixon, Illinois
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Illinois CancerCare-Eureka
Eureka, Illinois
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Illinois CancerCare-Galesburg
Galesburg, Illinois
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Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois
- I'm interested
Illinois CancerCare-Macomb
Macomb, Illinois
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Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois
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Illinois CancerCare-Pekin
Pekin, Illinois
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Illinois CancerCare-Peoria
Peoria, Illinois
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Illinois CancerCare-Peru
Peru, Illinois
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Illinois CancerCare-Princeton
Princeton, Illinois
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Methodist Medical Center of Illinois
Peoria, Illinois
- Call 765-751-5850
IU Health Ball Memorial Hospital
Muncie, Indiana
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- Call 317-834-3603
Franciscan Health Mooresville
Mooresville, Indiana
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- Call 317-528-7060
Franciscan Health Indianapolis
Indianapolis, Indiana
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Franciscan Saint Elizabeth Health - Lafayette East
Lafayette, Indiana
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Reid Health
Richmond, Indiana
- Call 515-956-4132
McFarland Clinic - Jefferson
Jefferson, Iowa
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- Call 515-956-4132
McFarland Clinic - Marshalltown
Marshalltown, Iowa
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Alegent Health Mercy Hospital
Council Bluffs, Iowa
- Call 515-956-4132
Mary Greeley Medical Center
Ames, Iowa
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McFarland Clinic - Ames
Ames, Iowa
- Call 515-956-4132
McFarland Clinic - Boone
Boone, Iowa
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Mercy Medical Center-West Lakes
West Des Moines, Iowa
- Call 515-956-4132
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa
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- Call 515-241-3305
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa
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- Call 515-241-3305
Mission Cancer and Blood - Laurel
Des Moines, Iowa
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Mercy Cancer Center-West Lakes
Clive, Iowa
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Mercy Medical Center - Des Moines
Des Moines, Iowa
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Greater Regional Medical Center
Creston, Iowa
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Lawrence Memorial Hospital
Lawrence, Kansas
- Call 785-270-4939
Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka, Kansas
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Salina Regional Health Center
Salina, Kansas
- Call 785-295-8000
University of Kansas Health System Saint Francis Campus
Topeka, Kansas
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Freeman Physician Group of Pittsburg
Pittsburg, Kansas
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Olathe Health Cancer Center
Olathe, Kansas
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Ascension Via Christi - Pittsburg
Pittsburg, Kansas
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Central Care Cancer Center - Great Bend
Great Bend, Kansas
- Call 785-623-5774
HaysMed University of Kansas Health System
Hays, Kansas
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Mercy Health - Paducah Medical Oncology and Hematology
Paducah, Kentucky
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Saint Joseph Hospital
Lexington, Kentucky
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Saint Joseph London
London, Kentucky
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Saint Joseph Mount Sterling
Mount Sterling, Kentucky
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Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky
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Commonwealth Cancer Center-Corbin
Corbin, Kentucky
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Flaget Memorial Hospital
Bardstown, Kentucky
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Saint Joseph Hospital East
Lexington, Kentucky
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University Medical Center New Orleans
New Orleans, Louisiana
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West Jefferson Medical Center
Marrero, Louisiana
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Louisiana State University Health Science Center
New Orleans, Louisiana
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University of Maryland Shore Medical Center at Easton
Easton, Maryland
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Lahey Medical Center-Peabody
Peabody, Massachusetts
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Winchester Hospital
Winchester, Massachusetts
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Lahey Hospital and Medical Center
Burlington, Massachusetts
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Spectrum Health at Butterworth Campus
Grand Rapids, Michigan
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Academic Hematology Oncology Specialists
Grosse Pointe Woods, Michigan
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Advanced Breast Care Center PLLC
Warren, Michigan
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Ascension Borgess Cancer Center
Kalamazoo, Michigan
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Ascension Saint John Hospital
Detroit, Michigan
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Ascension Saint Joseph Hospital
Tawas City, Michigan
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Ascension Saint Mary's Hospital
Saginaw, Michigan
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Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan
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Borgess Medical Center
Kalamazoo, Michigan
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Bronson Battle Creek
Battle Creek, Michigan
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Bronson Methodist Hospital
Kalamazoo, Michigan
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Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan
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Caro Cancer Center
Caro, Michigan
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Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan
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Genesee Hematology Oncology PC
Flint, Michigan
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Genesys Hurley Cancer Institute
Flint, Michigan
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Great Lakes Cancer Management Specialists-Doctors Park
East China, Michigan
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Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan
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Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan
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Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan
- I'm interested
Green Bay Oncology - Escanaba
Escanaba, Michigan
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Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids, Michigan
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Hematology Oncology Consultants-Clarkston
Clarkston, Michigan
- Call 517-265-0116
Hickman Cancer Center
Adrian, Michigan
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Hope Cancer Center
Pontiac, Michigan
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Hurley Medical Center
Flint, Michigan
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Huron Gastroenterology PC
Ypsilanti, Michigan
- Call 616-391-1230
Lakeland Hospital Niles
Niles, Michigan
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Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan
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Macomb Hematology Oncology PC
Warren, Michigan
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Marie Yeager Cancer Center
Saint Joseph, Michigan
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Michigan Breast Specialists-Warren
Warren, Michigan
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Munson Medical Center
Traverse City, Michigan
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Newland Medical Associates-Clarkston
Clarkston, Michigan
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Newland Medical Associates-Pontiac
Pontiac, Michigan
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Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan
- I'm interested
Saint John Macomb-Oakland Hospital
Warren, Michigan
- I'm interested
Saint Joseph Mercy Brighton
Brighton, Michigan
- I'm interested
Saint Joseph Mercy Canton
Canton, Michigan
- I'm interested
Saint Joseph Mercy Chelsea
Chelsea, Michigan
- I'm interested
Saint Joseph Mercy Hospital
Ann Arbor, Michigan
- I'm interested
Saint Joseph Mercy Oakland
Pontiac, Michigan
- I'm interested
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan
- I'm interested
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan
- Call 517-364-9400
Sparrow Hospital
Lansing, Michigan
This research site can be reached directly by phone. Call to ask about this study.
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21st Century Oncology-Pontiac
Pontiac, Michigan
- I'm interested
Spectrum Health Reed City Hospital
Reed City, Michigan
- Call 800-444-3561
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan
- I'm interested
Trinity Health Muskegon Hospital
Muskegon, Michigan
- I'm interested
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan
- I'm interested
University of Michigan Health - West
Wyoming, Michigan
- I'm interested
West Michigan Cancer Center
Kalamazoo, Michigan
- I'm interested
Cambridge Medical Center
Cambridge, Minnesota
- I'm interested
New Ulm Medical Center
New Ulm, Minnesota
- I'm interested
Saint Francis Regional Medical Center
Shakopee, Minnesota
- I'm interested
Fairview Northland Medical Center
Princeton, Minnesota
- I'm interested
Abbott-Northwestern Hospital
Minneapolis, Minnesota
- I'm interested
Minnesota Oncology - Burnsville
Burnsville, Minnesota
- I'm interested
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota
- I'm interested
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota
- I'm interested
Hennepin County Medical Center
Minneapolis, Minnesota
- I'm interested
North Memorial Medical Health Center
Robbinsdale, Minnesota
- I'm interested
Lakeview Hospital
Stillwater, Minnesota
- I'm interested
Monticello Cancer Center
Monticello, Minnesota
- I'm interested
Unity Hospital
Fridley, Minnesota
- I'm interested
Fairview Lakes Medical Center
Wyoming, Minnesota
- I'm interested
United Hospital
Saint Paul, Minnesota
- I'm interested
Ridgeview Medical Center
Waconia, Minnesota
- I'm interested
Rice Memorial Hospital
Willmar, Minnesota
- Call 605-312-3320
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota
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- I'm interested
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota
- Call 605-312-3320
Sanford Cancer Center Worthington
Worthington, Minnesota
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- I'm interested
Saint John's Hospital - Healtheast
Maplewood, Minnesota
- I'm interested
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota
- I'm interested
Health Partners Inc
Minneapolis, Minnesota
- I'm interested
Regions Hospital
Saint Paul, Minnesota
- I'm interested
Mercy Hospital
Coon Rapids, Minnesota
- I'm interested
Fairview Southdale Hospital
Edina, Minnesota
- I'm interested
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota
- I'm interested
Baptist Cancer Center-Grenada
Grenada, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi
- I'm interested
Gulfport Memorial Hospital
Gulfport, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi
- I'm interested
Capital Region Southwest Campus
Jefferson City, Missouri
- I'm interested
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri
- Call 314-251-7066
Mercy Hospital Saint Louis
St Louis, Missouri
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- I'm interested
Mercy Hospital South
St Louis, Missouri
- I'm interested
Saint Francis Medical Center
Cape Girardeau, Missouri
- Call 314-996-5569
Parkland Health Center - Farmington
Farmington, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 816-404-4375
Truman Medical Centers
Kansas City, Missouri
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- Call 573-882-7440
University of Missouri - Ellis Fischel
Columbia, Missouri
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- Call 417-269-4520
Mercy Hospital Springfield
Springfield, Missouri
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- I'm interested
Freeman Health System
Joplin, Missouri
- Call 636-390-1600
Mercy Hospital Washington
Washington, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 314-996-5569
Missouri Baptist Medical Center
St Louis, Missouri
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- Call 314-996-5569
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 314-996-5569
Missouri Baptist Sullivan Hospital
Sullivan, Missouri
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- Call 573-651-5550
Southeast Cancer Center
Cape Girardeau, Missouri
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- I'm interested
Heartland Regional Medical Center
Saint Joseph, Missouri
- Call 314-996-5569
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 314-205-6936
Saint Luke's Hospital
Chesterfield, Missouri
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- Call 417-269-4520
Cox Cancer Center Branson
Branson, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 417-269-4520
CoxHealth South Hospital
Springfield, Missouri
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- Call 314-353-1870
Saint Louis Cancer and Breast Institute-South City
St Louis, Missouri
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- Call 314-251-7058
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri
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- Call 573-458-6379
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri
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- I'm interested
Mercy Hospital Joplin
Joplin, Missouri
- I'm interested
Bozeman Deaconess Hospital
Bozeman, Montana
- I'm interested
Great Falls Clinic
Great Falls, Montana
- I'm interested
Kalispell Regional Medical Center
Kalispell, Montana
- I'm interested
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana
- I'm interested
Billings Clinic Cancer Center
Billings, Montana
- I'm interested
Community Hospital of Anaconda
Anaconda, Montana
- I'm interested
Community Medical Hospital
Missoula, Montana
- I'm interested
Saint Patrick Hospital - Community Hospital
Missoula, Montana
- I'm interested
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska
- I'm interested
Creighton University Medical Center
Omaha, Nebraska
- I'm interested
CHI Health Good Samaritan
Kearney, Nebraska
- I'm interested
Midlands Community Hospital
Papillion, Nebraska
- I'm interested
Alegent Health Lakeside Hospital
Omaha, Nebraska
- I'm interested
Alegent Health Immanuel Medical Center
Omaha, Nebraska
- I'm interested
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska
- I'm interested
Las Vegas Urology - Pebble
Henderson, Nevada
- I'm interested
Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada
- I'm interested
Las Vegas Prostate Cancer Center
Las Vegas, Nevada
- I'm interested
Urology Specialists of Nevada - Central
Las Vegas, Nevada
- I'm interested
Hope Cancer Care of Nevada
Las Vegas, Nevada
- I'm interested
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada
- I'm interested
Urology Specialists of Nevada - Green Valley
Henderson, Nevada
- I'm interested
Urology Specialists of Nevada - Northwest
Las Vegas, Nevada
- I'm interested
Urology Specialists of Nevada - Southwest
Las Vegas, Nevada
- I'm interested
OptumCare Cancer Care at Charleston
Las Vegas, Nevada
- I'm interested
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada
- I'm interested
OptumCare Cancer Care at MountainView
Las Vegas, Nevada
- I'm interested
OptumCare Cancer Care at Seven Hills
Henderson, Nevada
- I'm interested
GenesisCare USA - Vegas Tenaya
Las Vegas, Nevada
- I'm interested
GenesisCare USA - Las Vegas
Las Vegas, Nevada
- I'm interested
GenesisCare USA - Henderson
Henderson, Nevada
- I'm interested
GenesisCare USA - Fort Apache
Las Vegas, Nevada
- I'm interested
Radiation Oncology Associates
Reno, Nevada
- I'm interested
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada
- I'm interested
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada
- I'm interested
Renown Regional Medical Center
Reno, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada
- I'm interested
Saint Mary's Regional Medical Center
Reno, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada
- I'm interested
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada
- I'm interested
Carson Tahoe Regional Medical Center
Carson City, Nevada
- I'm interested
Ann M Wierman MD LTD
Las Vegas, Nevada
- I'm interested
Cancer and Blood Specialists-Henderson
Henderson, Nevada
- I'm interested
Summerlin Hospital Medical Center
Las Vegas, Nevada
- I'm interested
Sunrise Hospital and Medical Center
Las Vegas, Nevada
- I'm interested
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada
- I'm interested
University Cancer Center
Las Vegas, Nevada
- I'm interested
University Medical Center of Southern Nevada
Las Vegas, Nevada
- I'm interested
Las Vegas Urology - Sunset
Las Vegas, Nevada
- I'm interested
Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada
- I'm interested
Las Vegas Urology - Pecos
Las Vegas, Nevada
- I'm interested
Las Vegas Urology - Green Valley
Henderson, Nevada
- Call 800-339-6484
Solinsky Center for Cancer Care
Manchester, New Hampshire
This research site can be reached directly by phone. Call to ask about this study.
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- Call 603-224-2556
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire
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- I'm interested
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey
- I'm interested
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico
- I'm interested
Presbyterian Kaseman Hospital
Albuquerque, New Mexico
- I'm interested
University of New Mexico Cancer Center
Albuquerque, New Mexico
- I'm interested
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico
- I'm interested
Mount Sinai Chelsea
New York, New York
- I'm interested
Mount Sinai Hospital
New York, New York
- I'm interested
Mount Sinai West
New York, New York
- I'm interested
Mary Imogene Bassett Hospital
Cooperstown, New York
- Call 607-271-7000
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York
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- I'm interested
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York
- Call 585-275-5830
University of Rochester
Rochester, New York
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- I'm interested
CaroMont Regional Medical Center
Gastonia, North Carolina
- I'm interested
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina
- I'm interested
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina
- I'm interested
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina
- I'm interested
Outer Banks Hospital
Nags Head, North Carolina
- I'm interested
Sanford Roger Maris Cancer Center
Fargo, North Dakota
- Call 800-437-4010
Sanford Medical Center Fargo
Fargo, North Dakota
This research site can be reached directly by phone. Call to ask about this study.
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- Call 701-234-6161
Sanford South University Medical Center
Fargo, North Dakota
This research site can be reached directly by phone. Call to ask about this study.
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- Call 605-312-3320
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota
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- I'm interested
Sanford Broadway Medical Center
Fargo, North Dakota
- I'm interested
Sanford Bismarck Medical Center
Bismarck, North Dakota
- I'm interested
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio
- I'm interested
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio
- I'm interested
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio
- I'm interested
Riverside Methodist Hospital
Columbus, Ohio
- I'm interested
Orion Cancer Care
Findlay, Ohio
- I'm interested
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio
- I'm interested
OhioHealth Marion General Hospital
Marion, Ohio
- I'm interested
OhioHealth Mansfield Hospital
Mansfield, Ohio
- I'm interested
Fairfield Medical Center
Lancaster, Ohio
- I'm interested
Dublin Methodist Hospital
Dublin, Ohio
- I'm interested
Doctors Hospital
Columbus, Ohio
- I'm interested
Saint Ann's Hospital
Westerville, Ohio
- I'm interested
Saint Elizabeth Boardman Hospital
Boardman, Ohio
- I'm interested
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio
- I'm interested
Delaware Health Center-Grady Cancer Center
Delaware, Ohio
- I'm interested
North Coast Cancer Care
Sandusky, Ohio
- I'm interested
Newark Radiation Oncology
Newark, Ohio
- I'm interested
Dayton Physicians LLC-Wayne
Greenville, Ohio
- I'm interested
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio
- I'm interested
Dayton Physicians LLC-Atrium
Franklin, Ohio
- I'm interested
Dayton Physicians LLC - Troy
Troy, Ohio
- I'm interested
Dayton Physician LLC-Miami Valley Hospital North
Dayton, Ohio
- I'm interested
Saint Joseph Warren Hospital
Warren, Ohio
- I'm interested
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio
- I'm interested
Armes Family Cancer Center
Findlay, Ohio
- I'm interested
Wayne Hospital
Greenville, Ohio
- I'm interested
Marietta Memorial Hospital
Marietta, Ohio
- Call 419-226-9617
Saint Rita's Medical Center
Lima, Ohio
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- I'm interested
Saint Vincent Mercy Medical Center
Toledo, Ohio
- I'm interested
Indu and Raj Soin Medical Center
Beavercreek, Ohio
- I'm interested
Licking Memorial Hospital
Newark, Ohio
- I'm interested
Mount Carmel New Albany Surgical Hospital
New Albany, Ohio
- I'm interested
Mount Carmel Health Center West
Columbus, Ohio
- I'm interested
Columbus Oncology and Hematology Associates
Dublin, Ohio
- I'm interested
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio
- I'm interested
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio
- I'm interested
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio
- I'm interested
Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio
- I'm interested
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio
- I'm interested
Cleveland Clinic Cancer Center Independence
Independence, Ohio
- I'm interested
Mount Carmel Grove City Hospital
Grove City, Ohio
- I'm interested
Mount Carmel East Hospital
Columbus, Ohio
- I'm interested
South Pointe Hospital
Warrensville Heights, Ohio
- I'm interested
Southern Ohio Medical Center
Portsmouth, Ohio
- I'm interested
Springfield Regional Cancer Center
Springfield, Ohio
- I'm interested
Springfield Regional Medical Center
Springfield, Ohio
- I'm interested
Strecker Cancer Center-Belpre
Belpre, Ohio
- I'm interested
Blanchard Valley Hospital
Findlay, Ohio
- I'm interested
Bethesda North Hospital
Cincinnati, Ohio
- I'm interested
The Mark H Zangmeister Center
Columbus, Ohio
- I'm interested
Zangmeister Center Grove City
Grove City, Ohio
- Call 800-444-3561
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio
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- I'm interested
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio
- I'm interested
TriHealth Cancer Institute-Westside
Cincinnati, Ohio
- I'm interested
Adena Regional Medical Center
Chillicothe, Ohio
- I'm interested
Kettering Medical Center
Kettering, Ohio
- I'm interested
Knox Community Hospital
Mount Vernon, Ohio
- I'm interested
Mercy Health - Saint Anne Hospital
Toledo, Ohio
- I'm interested
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio
- I'm interested
Greater Dayton Cancer Center
Kettering, Ohio
- I'm interested
Grant Medical Center
Columbus, Ohio
- I'm interested
Grady Memorial Hospital
Delaware, Ohio
- Call 405-752-3402
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma
This research site can be reached directly by phone. Call to ask about this study.
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- Call 541-706-2909
Saint Charles Health System-Redmond
Redmond, Oregon
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- I'm interested
Saint Charles Health System
Bend, Oregon
- I'm interested
Saint Alphonsus Medical Center-Baker City
Baker City, Oregon
- I'm interested
Clackamas Radiation Oncology Center
Clackamas, Oregon
- Call 503-561-2618
Salem Hospital
Salem, Oregon
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- I'm interested
Providence Portland Medical Center
Portland, Oregon
- I'm interested
Bay Area Hospital
Coos Bay, Oregon
- I'm interested
Providence Saint Vincent Medical Center
Portland, Oregon
- I'm interested
Providence Newberg Medical Center
Newberg, Oregon
- I'm interested
Providence Willamette Falls Medical Center
Oregon City, Oregon
- I'm interested
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon
- I'm interested
Saint Alphonsus Medical Center-Ontario
Ontario, Oregon
- I'm interested
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania
- I'm interested
Doylestown Hospital
Doylestown, Pennsylvania
- I'm interested
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania
- I'm interested
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania
- I'm interested
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania
- I'm interested
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania
- I'm interested
Geisinger Medical Center
Danville, Pennsylvania
- I'm interested
Geisinger Medical Group
State College, Pennsylvania
- I'm interested
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania
- I'm interested
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania
- Call 610-983-1908
Phoenixville Hospital
Phoenixville, Pennsylvania
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Pocono Medical Center
East Stroudsburg, Pennsylvania
- I'm interested
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania
- I'm interested
Geisinger Medical Oncology-Selinsgrove
Selinsgrove, Pennsylvania
- I'm interested
Community Medical Center
Scranton, Pennsylvania
- Call 610-327-7544
Pottstown Hospital
Pottstown, Pennsylvania
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- I'm interested
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island
- I'm interested
South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina
- Call 864-241-6251
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina
This research site can be reached directly by phone. Call to ask about this study.
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- Call 864-241-6251
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina
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- Call 864-241-6251
Prisma Health Cancer Institute - Laurens
Clinton, South Carolina
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- Call 864-241-6251
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina
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Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina
- Call 864-241-6251
Prisma Health Cancer Institute - Faris
Greenville, South Carolina
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- Call 864-241-6251
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina
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- Call 864-241-6251
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina
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- Call 864-241-6251
Prisma Health Cancer Institute - Greer
Greer, South Carolina
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- I'm interested
Prisma Health Cancer Institute - Easley
Easley, South Carolina
- I'm interested
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota
- I'm interested
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota
- I'm interested
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee
- I'm interested
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee
- Call 931-783-2714
Cookeville Regional Medical Center
Cookeville, Tennessee
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- I'm interested
Sovah Health Martinsville
Martinsville, Virginia
- I'm interested
Chesapeake Regional Medical Center
Chesapeake, Virginia
- I'm interested
Valley Medical Center
Renton, Washington
- I'm interested
Providence Regional Cancer Partnership
Everett, Washington
- I'm interested
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington
- I'm interested
Providence Regional Cancer System-Yelm
Yelm, Washington
- I'm interested
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington
- I'm interested
PeaceHealth Saint John Medical Center
Longview, Washington
- Call 360-788-8223
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington
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- I'm interested
PeaceHealth Southwest Medical Center
Vancouver, Washington
- I'm interested
PeaceHealth United General Medical Center
Sedro-Woolley, Washington
- Call 360-344-3091
Jefferson Healthcare
Port Townsend, Washington
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Kadlec Clinic Hematology and Oncology
Kennewick, Washington
- I'm interested
Swedish Cancer Institute-Edmonds
Edmonds, Washington
- I'm interested
Swedish Cancer Institute-Issaquah
Issaquah, Washington
- I'm interested
Swedish Medical Center-Ballard Campus
Seattle, Washington
- I'm interested
Swedish Medical Center-Cherry Hill
Seattle, Washington
- I'm interested
Swedish Medical Center-First Hill
Seattle, Washington
- I'm interested
Kaiser Permanente Bellevue Medical Center
Bellevue, Washington
- I'm interested
Providence Regional Cancer System-Shelton
Shelton, Washington
- I'm interested
Providence Regional Cancer System-Lacey
Lacey, Washington
- I'm interested
Kaiser Permanente Washington
Seattle, Washington
- I'm interested
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington
- I'm interested
Providence Regional Cancer System-Centralia
Centralia, Washington
- I'm interested
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington
- I'm interested
Harrison Medical Center
Bremerton, Washington
- I'm interested
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin
- I'm interested
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin
- I'm interested
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin
- I'm interested
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin
- I'm interested
Gundersen Lutheran Medical Center
La Crosse, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin
- I'm interested
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin
- I'm interested
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin
- I'm interested
Marshfield Clinic - Ladysmith Center
Ladysmith, Wisconsin
- I'm interested
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin
- I'm interested
Langlade Hospital and Cancer Center
Antigo, Wisconsin
- I'm interested
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin
- Call 877-405-6866
Aspirus Regional Cancer Center
Wausau, Wisconsin
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Sheboygan Phyisicans Group
Sheboygan, Wisconsin
- I'm interested
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin
- I'm interested
Marshfield Clinic-Wausau Center
Wausau, Wisconsin
- I'm interested
Marshfield Medical Center - Weston
Weston, Wisconsin
- I'm interested
HSHS Sacred Heart Hospital
Eau Claire, Wisconsin
- I'm interested
Ascension Saint Michael's Hospital
Stevens Point, Wisconsin
- Call 715-422-7718
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Aspirus Medford Hospital
Medford, Wisconsin
- I'm interested
Cancer Center of Western Wisconsin
New Richmond, Wisconsin
- I'm interested
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming
- I'm interested
Billings Clinic-Cody
Cody, Wyoming
- I'm interested
Welch Cancer Center
Sheridan, Wyoming
Who can participate
Inclusion criteria
- ✓STEP 1 REGISTRATION
- ✓Patients must have a diagnosis of hormone receptor positive (estrogen receptor positive \[ER+\] and/or progesterone receptor positive \[PR+\]), HER-2 negative, metastatic (M1) breast cancer and must be receiving or plan to receive first-line systemic treatment for metastatic disease. (Systemic treatment is any treatment meant to treat the whole body such as endocrine therapy +/- targeted therapy +/- chemotherapy).
- ✓NOTE: Participants are eligible if they have either de-novo metastatic breast cancer and/or recurrent breast cancer from an earlier stage that is now metastatic
- ✓Patients must be registered to step 1 between 14 days prior to and 60 days after start of first-line systemic treatment for metastatic disease
- ✓Patients must have been tested for the following breast cancer specific STMs after diagnosis of metastatic disease and within +/-14 days of initiation of first-line systemic treatment for metastatic disease:
- ✓CEA (must be tested)
- ✓CA 15-3 or CA 27.29 (at least one of these must be tested)
- ✓At least one of the tested STMs must have been \>= 1.5 x the institutional upper limit of normal at this time.
- ✓Testing all three STMs is encouraged but only two are required. Patients must plan to have the same two STMs tested for the duration that the patient is on protocol-specified disease monitoring.
- ✓Patients must have systemic radiographic imaging prior to initiation of systemic therapy or within 30 days of initiation of treatment for metastatic breast cancer and prior to step 1 registration. Modality of imaging is at the discretion of the treating physician.
- ✓Note: the treating physician can order additional imaging tests at any point prior to randomization at their discretion
- ✓Patients must be willing to obtain disease monitoring (imaging and/or serum tumor markers) from a consistent facility in which the registering site has access to the results for the duration of the study intervention (312 weeks after step 2 randomization). Imaging and STMs do not need to be completed at the same facility.
- ✓Patients with known cirrhosis, untreated B12 deficiency, thalassemia, or sickle cell anemia are not eligible as these could cause falsely elevated STM levels
- ✓Patients with known brain leptomeningeal metastases are not eligible as they may require regular radiographic monitoring to assess treatment response
- ✓Patients must not be currently enrolled or plan to participate in a first-line treatment trial for metastatic breast cancer with a defined monitoring schedule
- ✓Patients who are able to complete questionnaires in English or Spanish must participate in patient-reported outcome (PRO) assessments
- ✓Patients must not be pregnant due to the potential harm to the fetus from radiation exposure from radiographic imaging
- ✓Except for breast cancer (and previous history of breast cancer), no other prior malignancy is allowed with the following exceptions:
- ✓Adequately treated basal (or squamous cell) skin cancer
- ✓Any cancer from which the patient has been disease free for five years
- ✓Prior Stage 0 or pre-cancerous lesions that have been removed with clear margins
- ✓Patients must not have received prior systemic therapy for metastatic breast cancer, except for their current line of therapy.
- ✓Patients must have decision making capacity and be able to provide informed consent
- ✓Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines; use of legally-authorized representative is not permissible for this study. Remote consent is allowed with adequate documentation.
- ✓As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- ✓STEP 2 RANDOMIZATION
- ✓Patients must be tested for the breast cancer specific STMs that were tested prior to STEP 1 Registration between 56 and 140 days after initiation of first-line systemic therapy for metastatic disease:
- ✓CEA (must be tested)
- ✓CA 15-3 or CA 27.29 (whichever was tested prior to Step 1)
- ✓Testing all three STMs is encouraged but only two are required. Patients must plan to have the same two STMs tested for the duration that the patient is on protocol-specified disease monitoring.
- ✓At least one of the STMs that was previously elevated must have decreased from the assessment at step 1 by \>= 10% at this time.
- ✓Patients must not have known progression since registration to step 1
- ✓Patients must be registered to step 2 randomization between 56 days and 140 days after the initiation of first-line systemic therapy for metastatic disease; This window is inclusive; patients may be registered to Step 2 on day 56 or Day 140. Patients must have been eligible for Step 1 in order to be eligible for Step 2 Randomization
- ✓Baseline questionnaires must be completed within 28 days prior to step 2 randomization; (Note: Those patients who cannot complete the PRO questionnaires in English or Spanish can be registered to step 2 without contributing to PRO research)
Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.
Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.