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Phase 2Recruiting

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Sponsored by University of Pennsylvania

About this study

This study will test whether pharmacologic agents that may improve mitochondrial function and energy fuel metabolism \[Empagliflozin (Empa)\], with and without additional supplements that increase perfusion and fatty acid oxidation \[Potassium Nitrate (KNO3)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).

Enrolling at this location

University of Pennsylvania Health System

Philadelphia, Pennsylvania

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Trial data sourced from ClinicalTrials.gov.