ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Sponsored by Alliance for Clinical Trials in Oncology
About this study
This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumab.
The primary and secondary objectives of the study: PRIMARY OBJECTIVES: I. To evaluate whether 6 months of combined neoadjuvant (neo)/adjuvant HER2 blockade results in a non-inferior recurrence-free survival (RFS) compared to 12 months of combined neo/adjuvant HER2 blockade, in patients with early stage HER2+ breast cancer who achieve pCR after neoadjuvant chemotherapy with HER2 blockade. II. To compare the Functional Assessment of Cancer Therapy-Breast (FACT-B) total score at 12 months between patients randomized to receive 6 months versus 12 months of combined neo/adjuvant HER2 blockade. (Quality of life) SECONDARY OBJECTIVES: I. Secondary objectives are to evaluate whether 6 months compared to 12 months results in differences for the following: Ia. Grade 3 or higher adverse event (…
Where this study is enrolling (596)
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Mayo Clinic Hospital in Arizona
Phoenix, Arizona
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NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas
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Kaiser Permanente-Vallejo
Vallejo, California
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Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California
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UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California
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University of California Davis Comprehensive Cancer Center
Sacramento, California
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UCI Health - Yorba Linda
Yorba Linda, California
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Woodland Memorial Hospital
Woodland, California
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Kaiser Permanente-Walnut Creek
Walnut Creek, California
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Torrance Memorial Physician Network - Cancer Care
Torrance, California
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Cedars-Sinai Cancer - Tarzana
Tarzana, California
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Kaiser Permanente-South San Francisco
South San Francisco, California
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Santa Rosa, California
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Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California
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Kaiser San Rafael-Gallinas
San Rafael, California
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Tower Cancer Research Foundation
Beverly Hills, California
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Mercy Cancer Center - Carmichael
Carmichael, California
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Mercy San Juan Medical Center
Carmichael, California
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Enloe Medical Center
Chico, California
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Kaiser Permanente Dublin
Dublin, California
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Mercy Cancer Center - Elk Grove
Elk Grove, California
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Emeryville, California
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Fremont, California
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Fresno, California
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California
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UC San Diego Moores Cancer Center
La Jolla, California
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Loma Linda University Medical Center
Loma Linda, California
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Marysville, California
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Modesto, California
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Modesto, California
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Oakland, California
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Stanford Cancer Institute Palo Alto
Palo Alto, California
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Huntington Memorial Hospital
Pasadena, California
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Mercy Cancer Center - Rocklin
Rocklin, California
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Roseville, California
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Kaiser Permanente Downtown Commons
Sacramento, California
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Mercy Cancer Center - Sacramento
Sacramento, California
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Sacramento, California
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San Diego, California
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San Francisco, California
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San Jose, California
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San Leandro, California
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Stanford Cancer Center South Bay
San Jose, California
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Salinas Valley Memorial
Salinas, California
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Eisenhower Medical Center
Rancho Mirage, California
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Washington Health
Fremont, California
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Saint John's Cancer Institute
Santa Monica, California
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Aurora, Colorado
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Colorado Springs, Colorado
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Memorial Hospital North
Colorado Springs, Colorado
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Kaiser Permanente-Franklin
Denver, Colorado
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Denver, Colorado
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Shaw Cancer Center
Edwards, Colorado
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Poudre Valley Hospital
Fort Collins, Colorado
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Fort Collins, Colorado
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Greeley, Colorado
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Highlands Ranch, Colorado
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Lafayette, Colorado
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Lone Tree, Colorado
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Medical Center of the Rockies
Loveland, Colorado
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Lone Tree, Colorado
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut
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Hartford, Connecticut
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New Haven, Connecticut
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North Haven, Connecticut
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Stamford, Connecticut
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Waterford, Connecticut
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Greenwich, Connecticut
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Fairfield, Connecticut
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Glastonbury, Connecticut
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Derby, Connecticut
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Helen F Graham Cancer Center
Newark, Delaware
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Medical Oncology Hematology Consultants PA
Newark, Delaware
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Beebe Health Campus
Rehoboth Beach, Delaware
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Millville, Delaware
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MedStar Washington Hospital Center
Washington D.C., District of Columbia
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia
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Jupiter Medical Center
Jupiter, Florida
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Morton Plant Hospital
Clearwater, Florida
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UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, Florida
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida
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UM Sylvester Comprehensive Cancer Center at Doral
Doral, Florida
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Mayo Clinic in Florida
Jacksonville, Florida
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The Watson Clinic
Lakeland, Florida
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UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida
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Sacred Heart Hospital
Pensacola, Florida
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UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida
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Mease Countryside Hospital
Safety Harbor, Florida
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Saint Anthony's Hospital Cancer Care Center
St. Petersburg, Florida
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Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida
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Winter Haven Hospital
Winter Haven, Florida
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University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, Florida
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UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, Florida
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UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida
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Mount Sinai Medical Center
Miami Beach, Florida
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South Florida Baptist Hospital
Plant City, Florida
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Grady Health System
Atlanta, Georgia
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Emory University Hospital Midtown
Atlanta, Georgia
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia
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Emory Saint Joseph's Hospital
Atlanta, Georgia
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Decatur, Georgia
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Johns Creek, Georgia
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Duluth, Georgia
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Lawrenceville, Georgia
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Atlanta, Georgia
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Phoebe Putney Memorial Hospital
Albany, Georgia
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Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii
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Saint Luke's Cancer Institute - Boise
Boise, Idaho
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Fruitland, Idaho
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Meridian, Idaho
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Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho
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Nampa, Idaho
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Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho
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Sandpoint, Idaho
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Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho
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Rush-Copley Healthcare Center
Yorkville, Illinois
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Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois
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UChicago Medicine AdventHealth Cancer Institute Hinsdale
Hinsdale, Illinois
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John H Stroger Jr Hospital of Cook County
Chicago, Illinois
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Illinois CancerCare-Galesburg
Galesburg, Illinois
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Advocate Good Shepherd Hospital
Barrington, Illinois
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Illinois CancerCare-Canton
Canton, Illinois
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SIH Cancer Institute
Carterville, Illinois
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Illinois CancerCare-Carthage
Carthage, Illinois
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Centralia Oncology Clinic
Centralia, Illinois
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Rush MD Anderson Cancer Center
Chicago, Illinois
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University of Illinois
Chicago, Illinois
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois
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Advocate Illinois Masonic Medical Center
Chicago, Illinois
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AMG Crystal Lake - Oncology
Crystal Lake, Illinois
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Carle at The Riverfront
Danville, Illinois
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Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois
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Decatur Memorial Hospital
Decatur, Illinois
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Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois
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Illinois CancerCare-Dixon
Dixon, Illinois
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Advocate Good Samaritan Hospital
Downers Grove, Illinois
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Carle Physician Group-Effingham
Effingham, Illinois
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Crossroads Cancer Center
Effingham, Illinois
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Advocate Sherman Hospital
Elgin, Illinois
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Illinois CancerCare-Eureka
Eureka, Illinois
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Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois
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Advocate South Suburban Hospital
Hazel Crest, Illinois
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Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois
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Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois
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AMG Libertyville - Oncology
Libertyville, Illinois
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Condell Memorial Hospital
Libertyville, Illinois
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Rush MD Anderson Cancer Center at Rush Lisle
Lisle, Illinois
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Illinois CancerCare-Macomb
Macomb, Illinois
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Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois
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Loyola University Medical Center
Maywood, Illinois
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Trinity Medical Center
Moline, Illinois
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Carle BroMenn Medical Center
Normal, Illinois
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Carle Cancer Institute Normal
Normal, Illinois
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Cancer Care Center of O'Fallon
O'Fallon, Illinois
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Northwestern Medicine Oak Brook
Oak Brook, Illinois
- Call 800-323-8622
Advocate Christ Medical Center
Oak Lawn, Illinois
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Advocate Outpatient Center - Oak Lawn
Oak Lawn, Illinois
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Northwestern Medicine Orland Park
Orland Park, Illinois
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Advocate Lutheran General Hospital
Park Ridge, Illinois
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Illinois CancerCare-Pekin
Pekin, Illinois
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Peru, Illinois
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Illinois CancerCare-Princeton
Princeton, Illinois
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UW Health Carbone Cancer Center Rockford
Rockford, Illinois
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Memorial Hospital East
Shiloh, Illinois
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Southern Illinois University School of Medicine
Springfield, Illinois
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Springfield Clinic
Springfield, Illinois
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Springfield Memorial Hospital
Springfield, Illinois
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Carle Cancer Center
Urbana, Illinois
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Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois
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Illinois CancerCare - Washington
Washington, Illinois
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Illinois CancerCare-Peoria
Peoria, Illinois
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Ingalls Memorial Hospital
Harvey, Illinois
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Bloomington, Illinois
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Rush MD Anderson Cancer Center at Rush Oak Park
Oak Park, Illinois
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Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois
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UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois
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Northwestern Medicine Cancer Center Delnor
Geneva, Illinois
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University of Chicago Medicine-Orland Park
Orland Park, Illinois
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Northwestern University
Chicago, Illinois
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Women's Diagnostic Center - Munster
Munster, Indiana
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Saint Mary Medical Center
Hobart, Indiana
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Northwest Cancer Center - Valparaiso
Valparaiso, Indiana
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Northwest Cancer Center - Crown Point
Crown Point, Indiana
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Saint Catherine Hospital
Indianapolis, Indiana
- Call 219-924-8178
Northwest Oncology LLC
Dyer, Indiana
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The Community Hospital
Munster, Indiana
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Northwest Cancer Center - Hobart
Hobart, Indiana
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Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana
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UChicago Medicine Northwest Indiana
Crown Point, Indiana
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IU Health North Hospital
Carmel, Indiana
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IU Health West Hospital
Avon, Indiana
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Mercy Hospital
Cedar Rapids, Iowa
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Saint Anthony Regional Hospital
Carroll, Iowa
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa
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UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa
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UI Healthcare Mission Cancer and Blood - Pella
Pella, Iowa
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UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa
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The Iowa Clinic PC
West Des Moines, Iowa
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Mercy Medical Center - Des Moines
Des Moines, Iowa
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McFarland Clinic - Ames
Ames, Iowa
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Mary Greeley Medical Center
Ames, Iowa
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McFarland Clinic - Marshalltown
Marshalltown, Iowa
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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa
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Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa
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McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa
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UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa
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Broadlawns Medical Center
Des Moines, Iowa
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Iowa Methodist Medical Center
Des Moines, Iowa
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Cancer Center of Kansas-Kingman
Kingman, Kansas
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Cancer Center of Kansas - Chanute
Chanute, Kansas
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Cancer Center of Kansas - Dodge City
Dodge City, Kansas
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Cancer Center of Kansas - El Dorado
El Dorado, Kansas
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University of Kansas Cancer Center-Overland Park
Overland Park, Kansas
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University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas
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Salina Regional Health Center
Salina, Kansas
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University of Kansas Health System Saint Francis Campus
Topeka, Kansas
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Cancer Center of Kansas - Wellington
Wellington, Kansas
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Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas
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Ascension Via Christi Hospitals Wichita
Wichita, Kansas
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Wichita, Kansas
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Winfield, Kansas
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Westwood, Kansas
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Salina, Kansas
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Parsons, Kansas
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Pratt, Kansas
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Liberal, Kansas
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Newton, Kansas
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Lawrence Memorial Hospital
Lawrence, Kansas
- I'm interested
The University of Kansas Cancer Center - Olathe
Olathe, Kansas
- Call 785-623-5774
HaysMed
Hays, Kansas
This research site can be reached directly by phone. Call to ask about this study.
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Cancer Center of Kansas-Independence
Independence, Kansas
- Call 502-562-3429
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky
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- I'm interested
UofL Health Medical Center Northeast
Louisville, Kentucky
- Call 859-257-3379
University of Kentucky/Markey Cancer Center
Lexington, Kentucky
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- I'm interested
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington, Louisiana
- I'm interested
Touro Infirmary
New Orleans, Louisiana
- I'm interested
LSU Health Sciences Center at Shreveport
Shreveport, Louisiana
- Call 318-813-1406
Ochsner LSU Health - Cancer Treatment Center
Shreveport, Louisiana
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Ochsner Medical Center Jefferson
New Orleans, Louisiana
- I'm interested
University Medical Center New Orleans
New Orleans, Louisiana
- I'm interested
Ochsner LSU Health Monroe Medical Center
Monroe, Louisiana
- Call 800-987-3005
Lafayette Family Cancer Center-EMMC
Brewer, Maine
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
MaineHealth Cancer Care and IV Therapy - Brunswick
Brunswick, Maine
- Call 207-626-4855
Harold Alfond Center for Cancer Care
Augusta, Maine
This research site can be reached directly by phone. Call to ask about this study.
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- Call 207-459-1600
MaineHealth Cancer Care Center of York County
Sanford, Maine
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- I'm interested
MaineHealth LincolnHealth Hospital
Damariscotta, Maine
- I'm interested
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine
- I'm interested
Penobscot Bay Medical Center
Rockport, Maine
- I'm interested
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, Maine
- I'm interested
UM Upper Chesapeake Hematology and Oncology - Aberdeen
Aberdeen, Maryland
- Call 301-668-7043
FMH James M Stockman Cancer Institute
Frederick, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 443-777-7364
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 410-601-9083
Sinai Hospital of Baltimore
Baltimore, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 443-849-3706
Greater Baltimore Medical Center
Baltimore, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 800-888-8823
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland
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- Call 410-553-8100
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland
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- Call 410-871-6400
William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster, Maryland
This research site can be reached directly by phone. Call to ask about this study.
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- Call 855-546-1944
MedStar Montgomery Medical Center
Olney, Maryland
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- I'm interested
University of Maryland Shore Medical Center at Easton
Easton, Maryland
- Call 240-964-1400
UPMC Western Maryland
Cumberland, Maryland
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- Call 301-877-4673
MedStar Southern Maryland Hospital Center
Clinton, Maryland
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- Call 301-319-2100
Walter Reed National Military Medical Center
Bethesda, Maryland
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- I'm interested
MedStar Health Bel Air Medical Campus
Bel Air, Maryland
- Call 443-643-3010
UM Upper Chesapeake Medical Center
Bel Air, Maryland
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- I'm interested
MedStar Good Samaritan Hospital
Baltimore, Maryland
- I'm interested
Lahey Clinic
Burlington, Massachusetts
- I'm interested
Baystate Medical Center
Springfield, Massachusetts
- I'm interested
Lahey Clinic Peabody
Peabody, Massachusetts
- Call 978-463-1374
Beverly Hospital Cancer Center at Anna Jaques
Newburyport, Massachusetts
This research site can be reached directly by phone. Call to ask about this study.
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- Call 877-442-3324
Dana-Farber Cancer Institute
Boston, Massachusetts
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- I'm interested
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan
- I'm interested
University of Michigan Health - West
Wyoming, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan
- I'm interested
Munson Medical Center
Traverse City, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan
- Call 800-865-1125
University of Michigan - Brighton Center for Specialty Care
Brighton, Michigan
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- I'm interested
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan
- I'm interested
Bronson Battle Creek
Battle Creek, Michigan
- I'm interested
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan
- I'm interested
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan
- I'm interested
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan
- I'm interested
Cancer Hematology Centers - Flint
Flint, Michigan
- I'm interested
Genesys Hurley Cancer Institute
Flint, Michigan
- I'm interested
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan
- I'm interested
Bronson Methodist Hospital
Kalamazoo, Michigan
- I'm interested
West Michigan Cancer Center
Kalamazoo, Michigan
- I'm interested
University of Michigan Health - Sparrow Lansing
Lansing, Michigan
- I'm interested
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan
- I'm interested
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan
- Call 616-391-1230
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan
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- I'm interested
Henry Ford Wyandotte Hospital
Wyandotte, Michigan
- I'm interested
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan
- I'm interested
Henry Ford Medical Center-Columbus
Novi, Michigan
- I'm interested
Henry Ford Health Providence Novi Hospital
Novi, Michigan
- I'm interested
Allegiance Health
Jackson, Michigan
- I'm interested
Henry Ford Hospital
Detroit, Michigan
- I'm interested
Henry Ford Medical Center-Fairlane
Dearborn, Michigan
- I'm interested
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan
- I'm interested
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan
- I'm interested
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan
- I'm interested
Newland Medical Associates-Pontiac
Pontiac, Michigan
- I'm interested
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan
- I'm interested
Corewell Health Reed City Hospital
Reed City, Michigan
- I'm interested
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan
- Call 605-312-3320
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota
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- I'm interested
Essentia Health Virginia Clinic
Virginia, Minnesota
- Call 605-312-3320
Sanford Cancer Center Worthington
Worthington, Minnesota
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- I'm interested
Essentia Health - Deer River Clinic
Deer River, Minnesota
- I'm interested
Mercy Hospital
Coon Rapids, Minnesota
- I'm interested
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota
- I'm interested
Abbott-Northwestern Hospital
Minneapolis, Minnesota
- Call 855-776-0015
Mayo Clinic in Rochester
Rochester, Minnesota
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- I'm interested
Saint Francis Regional Medical Center
Shakopee, Minnesota
- I'm interested
Essentia Health Cancer Center
Duluth, Minnesota
- I'm interested
Fairview Southdale Hospital
Edina, Minnesota
- Call 218-786-3308
Essentia Health Hibbing Clinic
Hibbing, Minnesota
This research site can be reached directly by phone. Call to ask about this study.
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- Call 855-776-0015
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota
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- I'm interested
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota
- I'm interested
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota
- I'm interested
Lakeview Hospital
Stillwater, Minnesota
- I'm interested
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota
- I'm interested
Regions Hospital
Saint Paul, Minnesota
- I'm interested
United Hospital
Saint Paul, Minnesota
- I'm interested
Essentia Health Sandstone
Sandstone, Minnesota
- I'm interested
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi
- I'm interested
Baptist Cancer Center-Grenada
Grenada, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi
- I'm interested
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi
- Call 913-588-1569
Liberty Hospital
Liberty, Missouri
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- I'm interested
Lake Regional Hospital
Osage Beach, Missouri
- I'm interested
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri
- I'm interested
Siteman Cancer Center-South County
St Louis, Missouri
- Call 314-996-5569
Missouri Baptist Medical Center
St Louis, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Siteman Cancer Center at Christian Hospital
St Louis, Missouri
- Call 314-251-7066
Mercy Hospital Saint Louis
St Louis, Missouri
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- Call 314-996-5569
Missouri Baptist Sullivan Hospital
Sullivan, Missouri
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- I'm interested
Washington University School of Medicine
St Louis, Missouri
- Call 314-996-5569
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri
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- I'm interested
Mercy Hospital South
St Louis, Missouri
- Call 888-446-3729
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri
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- I'm interested
Saint Francis Medical Center
Cape Girardeau, Missouri
- I'm interested
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri
- I'm interested
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri
- Call 314-996-5569
Parkland Health Center - Farmington
Farmington, Missouri
This research site can be reached directly by phone. Call to ask about this study.
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- Call 816-404-4375
University Health Truman Medical Center
Kansas City, Missouri
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- Call 913-588-3671
University of Kansas Cancer Center - Briarcliff
Kansas City, Missouri
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- I'm interested
University of Kansas Cancer Center - North
Kansas City, Missouri
- I'm interested
Community Medical Center
Missoula, Montana
- I'm interested
Community Hospital of Anaconda
Anaconda, Montana
- I'm interested
Billings Clinic Cancer Center
Billings, Montana
- I'm interested
Bozeman Health Deaconess Hospital
Bozeman, Montana
- I'm interested
Benefis Sletten Cancer Institute
Great Falls, Montana
- I'm interested
Logan Health Medical Center
Kalispell, Montana
- I'm interested
University of Nebraska Medical Center
Omaha, Nebraska
- I'm interested
Nebraska Medicine-Bellevue
Bellevue, Nebraska
- Call 402-559-5600
Nebraska Medicine-Village Pointe
Omaha, Nebraska
This research site can be reached directly by phone. Call to ask about this study.
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- Call 800-339-6484
Solinsky Center for Cancer Care
Manchester, New Hampshire
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire
- Call 603-224-2556
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire
This research site can be reached directly by phone. Call to ask about this study.
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- I'm interested
Jefferson Cherry Hill Hospital
Cherry Hill, New Jersey
- Call 856-325-6757
Cooper Hospital University Medical Center
Camden, New Jersey
This research site can be reached directly by phone. Call to ask about this study.
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- Call 201-894-3456
Englewood Hospital and Medical Center
Englewood, New Jersey
This research site can be reached directly by phone. Call to ask about this study.
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- Call 551-996-2897
Hackensack University Medical Center
Hackensack, New Jersey
This research site can be reached directly by phone. Call to ask about this study.
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- Call 973-971-5900
Morristown Medical Center
Morristown, New Jersey
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- I'm interested
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey
- Call 908-522-2043
Overlook Hospital
Summit, New Jersey
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- I'm interested
Saint Joseph's Regional Medical Center
Paterson, New Jersey
- I'm interested
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico
- I'm interested
Presbyterian Kaseman Hospital
Albuquerque, New Mexico
- I'm interested
University of New Mexico Cancer Center
Albuquerque, New Mexico
- Call 315-472-7504
Hematology Oncology Associates of CNY at Camillus
Camillus, New York
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- I'm interested
Roswell Park Cancer Institute
Buffalo, New York
- Call 315-472-7504
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 516-734-8896
Northwell Health Cancer Institute at Huntington
Greenlawn, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 516-734-8896
Northwell Health/Center for Advanced Medicine
Lake Success, New York
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- I'm interested
Northern Westchester Hospital
Mount Kisco, New York
- I'm interested
Pluta Cancer Center
Rochester, New York
- Call 914-366-1600
Phelps Memorial Hospital Center
Sleepy Hollow, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 718-226-8888
Staten Island University Hospital
Staten Island, New York
This research site can be reached directly by phone. Call to ask about this study.
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- Call 800-862-2215
Stony Brook University Medical Center
Stony Brook, New York
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- I'm interested
Montefiore Medical Center-Einstein Campus
The Bronx, New York
- I'm interested
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York
- I'm interested
The New York Hospital Medical Center of Queens
Flushing, New York
- Call 212-746-1848
NYP/Weill Cornell Medical Center
New York, New York
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- I'm interested
Unity Park Ridge Campus
Rochester, New York
- I'm interested
Rochester General Hospital
Rochester, New York
- I'm interested
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York
- I'm interested
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina
- I'm interested
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina
- I'm interested
Duke Cancer Center Cary
Cary, North Carolina
- I'm interested
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina
- I'm interested
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina
- I'm interested
Novant Health Presbyterian Medical Center
Charlotte, North Carolina
- I'm interested
Novant Health Cancer Institute - Kernersville
Kernersville, North Carolina
- Call 888-275-3853
Duke University Medical Center
Durham, North Carolina
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- I'm interested
Novant Health Cancer Institute - Huntersville
Huntersville, North Carolina
- I'm interested
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina
- I'm interested
Novant Health Cancer Institute - Matthews
Matthews, North Carolina
- I'm interested
Novant Health Cancer Institute - Mooresville
Mooresville, North Carolina
- I'm interested
Novant Health Cancer Institute - Mount Airy
Mount Airy, North Carolina
- Call 919-785-4878
Duke Women's Cancer Care Raleigh
Raleigh, North Carolina
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Novant Health Cancer Institute - Thomasville
Thomasville, North Carolina
- I'm interested
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina
- I'm interested
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina
- I'm interested
Sanford Roger Maris Cancer Center
Fargo, North Dakota
- I'm interested
Sanford Broadway Medical Center
Fargo, North Dakota
- I'm interested
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota
- I'm interested
Sanford Bismarck Medical Center
Bismarck, North Dakota
- Call 937-569-7515
Miami Valley Cancer Care and Infusion
Greenville, Ohio
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- I'm interested
Upper Valley Medical Center
Troy, Ohio
- I'm interested
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio
- I'm interested
Ohio State University Comprehensive Cancer Center
Columbus, Ohio
- I'm interested
Miami Valley Hospital
Dayton, Ohio
- I'm interested
Miami Valley Hospital North
Dayton, Ohio
- I'm interested
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio
- I'm interested
ProMedica Flower Hospital
Sylvania, Ohio
- I'm interested
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio
- I'm interested
Aultman Health Foundation
Canton, Ohio
- I'm interested
Miami Valley Hospital South
Centerville, Ohio
- I'm interested
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio
- Call 405-752-3402
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
- Call 877-231-4440
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma
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- Call 503-413-2150
Legacy Mount Hood Medical Center
Gresham, Oregon
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Providence Saint Vincent Medical Center
Portland, Oregon
- Call 503-413-1742
Legacy Meridian Park Hospital
Tualatin, Oregon
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Providence Portland Medical Center
Portland, Oregon
- I'm interested
Providence Willamette Falls Medical Center
Oregon City, Oregon
- I'm interested
Saint Charles Health System
Bend, Oregon
- I'm interested
Asante Rogue Regional Medical Center
Medford, Oregon
- Call 541-472-7000
Three Rivers Community Hospital
Grants Pass, Oregon
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- I'm interested
Providence Newberg Medical Center
Newberg, Oregon
- I'm interested
Providence Hood River Memorial Hospital
Hood River, Oregon
- I'm interested
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon
- I'm interested
UPMC Hillman Cancer Center - Passavant - Cranberry
Cranberry Township, Pennsylvania
- Call 717-721-4840
Ephrata Cancer Center
Ephrata, Pennsylvania
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- I'm interested
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania
- Call 814-452-5000
Saint Vincent Hospital
Erie, Pennsylvania
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- I'm interested
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania
- Call 814-534-4724
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, Pennsylvania
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- I'm interested
Jefferson Hospital
Jefferson Hills, Pennsylvania
- I'm interested
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania
- Call 877-441-7957
Adams Cancer Center
Gettysburg, Pennsylvania
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- I'm interested
UPMC Cancer Center-Uniontown
Uniontown, Pennsylvania
- I'm interested
UPMC Cancer Center-Washington
Washington, Pennsylvania
- Call 814-676-7900
UPMC Cancer Center at UPMC Northwest
Seneca, Pennsylvania
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Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania
- I'm interested
IRMC Cancer Center
Indiana, Pennsylvania
- I'm interested
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania
- I'm interested
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania
- Call 724-838-1900
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania
This research site can be reached directly by phone. Call to ask about this study.
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- Call 412-784-4900
UPMC-Saint Margaret
Pittsburgh, Pennsylvania
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- Call 412-647-2811
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania
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- Call 877-284-2000
Allegheny General Hospital
Pittsburgh, Pennsylvania
This research site can be reached directly by phone. Call to ask about this study.
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- Call 610-983-1800
Reading Hospital McGlinn Cancer Institute at Phoenixville
Phoenixville, Pennsylvania
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- I'm interested
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania
- I'm interested
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania
- I'm interested
UPMC Hillman Cancer Center - New Castle
New Castle, Pennsylvania
- I'm interested
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania
- I'm interested
UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania
- Call 412-858-7746
Forbes Hospital
Monroeville, Pennsylvania
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UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania
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Yolanda G Barco Oncology Institute
Meadville, Pennsylvania
- Call 412-647-8073
UPMC Cancer Center at UPMC McKeesport
McKeesport, Pennsylvania
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Sechler Family Cancer Center
Lebanon, Pennsylvania
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UPMC Hillman Cancer Center at Butler Health System
Butler, Pennsylvania
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Carlisle Regional Cancer Center
Carlisle, Pennsylvania
- Call 412-647-8073
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania
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- Call 717-217-6020
WellSpan Medical Oncology and Hematology
Chambersburg, Pennsylvania
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Geisinger Cancer Center Dickson City
Dickson City, Pennsylvania
- Call 877-441-7957
WellSpan Health-York Cancer Center
York, Pennsylvania
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Asplundh Cancer Pavilion
Willow Grove, Pennsylvania
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Divine Providence Hospital
Williamsport, Pennsylvania
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Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania
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Wexford Health and Wellness Pavilion
Wexford, Pennsylvania
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UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania
- Call 610-988-9323
Reading Hospital
West Reading, Pennsylvania
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- Call 412-653-8100
UPMC West Mifflin-Cancer Center Jefferson
West Mifflin, Pennsylvania
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- Call 800-836-0388
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania
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- Call 412-502-3920
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania
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- Call 412-367-6454
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania
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- Call 401-444-1488
Rhode Island Hospital
Providence, Rhode Island
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- Call 401-274-1122
Women and Infants Hospital
Providence, Rhode Island
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Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island
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Beaufort Memorial Hospital
Beaufort, South Carolina
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Prisma Health Cancer Institute - Greer
Greer, South Carolina
- I'm interested
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina
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Prisma Health Cancer Institute - Butternut
Greenville, South Carolina
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Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina
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Prisma Health Cancer Institute - Easley
Easley, South Carolina
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Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina
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Lexington Health
West Columbia, South Carolina
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Medical University of South Carolina
Charleston, South Carolina
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Prisma Health Cancer Institute - Eastside
Greenville, South Carolina
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Prisma Health Cancer Institute - Faris
Greenville, South Carolina
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Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota
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Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota
- I'm interested
Rapid City Regional Hospital
Rapid City, South Dakota
- I'm interested
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee
- Call 865-544-9773
University of Tennessee - Knoxville
Knoxville, Tennessee
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Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee
- Call 281.274.7000
Houston Methodist Sugar Land Hospital
Sugar Land, Texas
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Houston Methodist Cypress Hospital
Cypress, Texas
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Houston Methodist San Jacinto Hospital
Baytown, Texas
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UT MD Anderson - The Woodlands
Conroe, Texas
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UT MD Anderson Cancer Center
Houston, Texas
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UT MD Anderson - West Houston
Houston, Texas
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Covenant Medical Center-Lakeside
Lubbock, Texas
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UT MD Anderson - League City
League City, Texas
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UT MD Anderson - Sugar Land
Sugar Land, Texas
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Methodist Willowbrook Hospital
Houston, Texas
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Houston Methodist The Woodlands Hospital
The Woodlands, Texas
- Call 713-566-5000
Lyndon Baines Johnson General Hospital
Houston, Texas
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- Call 713.790.3311
Houston Methodist Hospital
Houston, Texas
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- Call 832.522.6070
Houston Methodist West Hospital
Houston, Texas
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Houston Methodist Saint John Hospital
Nassau Bay, Texas
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah
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Farmington Health Center
Farmington, Utah
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University of Utah Sugarhouse Health Center
Salt Lake City, Utah
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South Jordan Health Center
South Jordan, Utah
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University of Vermont Medical Center
Burlington, Vermont
- I'm interested
University of Vermont and State Agricultural College
Burlington, Vermont
- I'm interested
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont
- Call 802-225-5400
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia
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Virginia Cancer Institute
Richmond, Virginia
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Bon Secours Saint Mary's Hospital
Richmond, Virginia
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Bon Secours Saint Francis Medical Center
Midlothian, Virginia
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Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia
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Centra Alan B Pearson Regional Cancer Center
Lynchburg, Virginia
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VCU Community Memorial Health Center
South Hill, Virginia
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VCU Massey Cancer Center at Stony Point
Richmond, Virginia
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Swedish Cancer Institute-Edmonds
Edmonds, Washington
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Skagit Regional Health Cancer Care Center
Mount Vernon, Washington
- Call 503-413-2150
Legacy Salmon Creek Hospital
Vancouver, Washington
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Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington
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Swedish Medical Center-First Hill
Seattle, Washington
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Swedish Cancer Institute-Issaquah
Issaquah, Washington
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Edwards Comprehensive Cancer Center
Huntington, West Virginia
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WVUH-Berkely Medical Center
Martinsburg, West Virginia
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United Hospital Center
Bridgeport, West Virginia
- Call 304-526-1349
Saint Mary's Medical Center
Huntington, West Virginia
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West Virginia University Healthcare
Morgantown, West Virginia
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Camden Clark Medical Center
Parkersburg, West Virginia
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Aurora BayCare Medical Center
Green Bay, Wisconsin
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Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin
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Aurora Saint Luke's South Shore
Cudahy, Wisconsin
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Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin
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Duluth Clinic Ashland
Ashland, Wisconsin
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Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin
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University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin
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Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
Rhinelander, Wisconsin
- I'm interested
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin
- Call 715-422-7718
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin
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- Call 855-776-0015
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin
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- Call 877-405-6866
Aspirus Cancer Care-Wausau
Wausau, Wisconsin
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Cancer Center of Western Wisconsin
New Richmond, Wisconsin
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ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin
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Gundersen Lutheran Medical Center
La Crosse, Wisconsin
- Call 920-435-8326
Bellin Memorial Hospital
Green Bay, Wisconsin
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ThedaCare Regional Cancer Center
Appleton, Wisconsin
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Aspirus Cancer Care-Antigo-Volm Cancer Center
Antigo, Wisconsin
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Aurora Health Care Germantown Health Center
Germantown, Wisconsin
- I'm interested
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin
- Call 414-805-0505
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin
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Aurora West Allis Medical Center
West Allis, Wisconsin
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Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin
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Aurora Cancer Care-Grafton
Grafton, Wisconsin
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Sheboygan Physicians Group
Sheboygan, Wisconsin
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Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin
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Aurora Medical Center in Summit
Summit, Wisconsin
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Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin
- I'm interested
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin
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Aurora Cancer Care-Racine
Racine, Wisconsin
- I'm interested
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin
- I'm interested
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin
- Call 414-805-0505
Drexel Town Square Health Center
Oak Creek, Wisconsin
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- Call 414-805-0505
Froedtert and MCW Moorland Reserve Health Center
New Berlin, Wisconsin
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Aurora Sinai Medical Center
Milwaukee, Wisconsin
- Call 414-805-3666
Medical College of Wisconsin
Milwaukee, Wisconsin
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Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin
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Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin
- Call 262-257-5100
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin
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Aspirus Medford Hospital
Medford, Wisconsin
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Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin
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Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin
- Call 855-776-0015
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin
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Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin
Who can participate
Inclusion criteria
- ✓Patients (females and males) with clinical stage T1c-T3 (or Tx) and nodal stage N0-N1 (except T3N1 tumors, which are not eligible)
- ✓Patients must have no residual invasive disease in the breast or lymph nodes after the completion of neoadjuvant therapy. Residual ductal carcinoma in situ (DCIS) is allowed. Patients with residual isolated tumor cells at surgery are considered node-positive and are not eligible
- ✓HER2+ by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines. Central pathology review is not required. In cases where there were multiple tumor sites in breast/nodes that had HER2 testing at diagnosis, at least one site must have been HER2+ AND the treating investigator must feel it is in the patient's best interest to be treated as having HER2+ breast cancer
- ✓Known hormone receptor status as defined by ASCO/CAP guidelines. Estrogen receptor (ER) and progesterone receptor (PR) of any values are allowed. Hormone receptor positive status can be determined by either known positive ER or known positive PR status; hormone receptor negative status must be determined by both known negative ER and known negative PR
- ✓If invasive disease was present in both breasts, participation in the study is permitted as long as the eligibility criteria are met for both tumors/breasts (including the requirement that at least one biopsied site on each side must have been HER2+)
- ✓Age ≥ 18 years
- ✓Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- ✓Patients must have received neoadjuvant chemotherapy in combination with trastuzumab with or without pertuzumab for a minimum of 12 weeks. All chemotherapy must have been completed preoperatively
- ✓Patient must complete a minimum of 12 weeks of coverage with trastuzumab and a maximum of 24 weeks in the combined neoadjuvant and adjuvant setting prior to trial registration. Trastuzumab may have been administered either weekly or once every 3 weeks (q3weeks). (For purposes of this eligibility criterion, a single dose of q3week trastuzumab would provide 3 weeks of coverage; a single dose of once a week (q1week) trastuzumab would provide 1 week of coverage. If a q3week dose of trastuzumab were administered and then the subsequent dose was delayed for any period of time, that would still count as 3 weeks of coverage.)
- ✓Administration of endocrine therapy for treatment of this breast cancer is allowed prior to trial registration. If a patient received prior breast cancer endocrine therapy (eg tamoxifen or aromatase inhibitor) for DCIS or preventive indication, and endocrine therapy is indicated for treatment of their current breast cancer, then prior endocrine therapy must have been stopped \> 12 months prior to registration on this protocol
- ✓No use of investigational anti-cancer agents at time of registration
- ✓Patient must register within 14 weeks of final surgery
- ✓Adequate excision: Surgical removal of all clinically evident disease in the breast and lymph nodes as follows:
- ✓Breast surgery: Total mastectomy with grossly negative margins (in the opinion of the surgeon there is no disease grossly at the margins) or breast-conserving surgery with histologically negative margins (no ink on tumor, including DCIS) unless those margins are anterior at the skin or posterior at the chest wall and no additional margin re-excision can be performed
- ✓Lymph node surgery: Lymph node surgery must have been performed and can include sentinel lymph node biopsy, targeted axillary dissection, or axillary dissection, at the discretion of the breast surgeon
- ✓Adequate radiation: Patients who completed breast-conserving surgery (i.e. lumpectomy) must have received or plan to receive adjuvant radiation. If breast-conserving surgery was performed but patient will not be receiving breast radiation, the patient is not eligible. Patients for whom radiotherapy would be recommended for breast cancer treatment but for whom it is contraindicated because of medical reasons (e.g., connective tissue disorder or prior ipsilateral breast radiation) are not eligible
- ✓Adjuvant radiation can be given on study, and in this case is encouraged to be given concurrently with adjuvant HER2-directed therapy, per investigator discretion
- ✓Targeting of the regional nodal basins will be at treating investigator discretion
- ✓Not pregnant and not nursing, because this study involves agents with known teratogenic potential. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test should be performed prior to receiving HER2-directed therapy according to local standard practice
- ✓Adequate hepatic, renal and bone marrow function to receive adjuvant HER2-directed therapy in the opinion of the treating investigator. There are no specific required laboratory values for eligibility
- ✓No stage IV (metastatic) breast cancer
- ✓Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- ✓No history of any prior (ipsilateral \[ipsi-\] or contralateral) invasive breast cancer. Prior DCIS is allowed
- ✓No evidence of recurrent disease following preoperative therapy and surgery
- ✓Patients living with HIV who are healthy and deemed by their medical team to have a low risk of AIDS-related illnesses are included in this trial. Patients with Hepatitis B or Hepatitis C virus who are healthy and deemed by their medical team to meet all other enrollment criteria are included in this trial.
- ✓Patients with inadequate cardiac function on most recent assessment of left ventricular ejection fraction (LVEF) are not eligible for this trial. Inadequate cardiac function is defined as LVEF \< 50% on echocardiogram (echo) or multiple-gated acquisition (MUGA)
- ✓No history of grade 3 or 4 toxicity related to trastuzumab. If pertuzumab is planned to be given on trial, patient must also have no history of grade 3-4 toxicity related to pertuzumab
- ✓No contraindication to receipt of further HER2-directed therapy
- ✓No patients with severe, uncontrolled systemic disease that may interfere with planned trial therapy.
Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.
Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.