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Phase 3Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Sponsored by Eli Lilly and Company

About this study

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.

Where this study is enrolling (37)

  • Infirmary Cancer Care

    Mobile, Alabama

    Call 251-435-2273

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  • The University of Arizona Cancer Center - North Campus

    Tucson, Arizona

    Call 520-626-3434

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  • Highlands Oncology Group

    Springdale, Arkansas

    Call 479-872-8130

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  • Stanford Cancer Center

    Palo Alto, California

    Call 650-725-3081

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  • UCLA Hematology/Oncology - Santa Monica

    Los Angeles, California

    Call 310-794-7333

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Show all 37 locations

  • Comprehensive Hematology Oncology

    St. Petersburg, Florida

    Call 727-344-6569

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  • Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala

    Ocala, Florida

    Call 352-732-4032

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  • Moffitt Cancer Center

    Tampa, Florida

    Call 813-745-2677

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  • University Cancer & Blood Center, LLC

    Athens, Georgia

    Call 706-353-2990

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  • Winship Cancer Institute

    Atlanta, Georgia

    I'm interested

  • University of Chicago Medical Center

    Chicago, Illinois

    I'm interested

  • Franciscan Health

    Indianapolis, Indiana

    Call 317-528-5173

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  • Mary Bird Perkins Cancer Center

    Baton Rouge, Louisiana

    Call 225-215-1185

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  • Ochsner Health Ochsner Cancer Center - Baton Rouge

    Baton Rouge, Louisiana

    Call 504-842-3910

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  • Ochsner Clinic Foundation

    New Orleans, Louisiana

    Call 504-842-3910

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  • New England Cancer Specialists

    Westbrook, Maine

    Call 207-303-3300

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  • Lahey Hospital & Medical Center

    Burlington, Massachusetts

    Call 781-744-8400

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  • Reliant Medical Group

    Worcester, Massachusetts

    Call 508-556-5400

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  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire

    Call 603-650-6344

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  • Northport VA Medical Center

    Northport, New York

    Call 631-261-4400 x12581

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  • Columbia University Irving Medical Center

    New York, New York

    Call 212-305-3997

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  • Memorial Sloan Kettering Cancer Center

    New York, New York

    Call 646-608-3761

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  • Aultman Hospital

    Canton, Ohio

    Call 330-438-6333

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  • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T

    Columbus, Ohio

    Call 614-293-3300

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  • Oregon Health and Science University

    Portland, Oregon

    Call 971-262-9000

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  • Kaiser Permanente Interstate Medical Office Central

    Portland, Oregon

    Call 503-249-3315

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  • Lexington Medical Center

    West Columbia, South Carolina

    Call 803-794-7511

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  • Avera Cancer Institute- Research

    Sioux Falls, South Dakota

    Call 605-322-6900

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  • University of Tennessee Medical Center

    Knoxville, Tennessee

    Call 865-305-8780

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  • University of Texas MD Anderson Cancer Center

    Houston, Texas

    Call 877-632-6789

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  • Houston Methodist Hospital

    Houston, Texas

    Call 713.790.3311

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  • The Center for Cancer and Blood Disorders

    Fort Worth, Texas

    Call 817-759-7000

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  • Kelsey-Seybold Clinic

    Houston, Texas

    Call 713-442-1700

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  • USO - Texas Oncology Gulf Coast

    Sugar Land, Texas

    Call 281-277-5200

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  • VCU Health Adult Outpatient Pavillion

    Richmond, Virginia

    Call 804-828-7999

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  • University of Virginia Health System

    Charlottesville, Virginia

    Call 434-924-4251

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  • University Hospital and UW Health Clinics

    Madison, Wisconsin

    Call 608-261-1500

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Who can participate

Inclusion criteria

  • ✓Histological or cytological confirmation of NSCLC.
  • ✓Part A
  • ✓1. Clinical Stage II-IIIB (N0, N1, N2) treated with presurgical chemoimmunotherapy, with residual tumor present at time of surgery. Patients with a pathologic complete response are not eligible.
  • ✓2. Pathologic Stage II-IIIB (N0, N1, N2) NSCLC treated with initial upfront resection.
  • ✓Part B - Clinical Stage III, unresectable NSCLC, without progression on concurrent platinum-based chemoradiotherapy.
  • ✓Must have disease with evidence of KRAS G12C mutation.
  • ✓Must have known programmed death-ligand 1 (PD-L1) expression
  • ✓Must have an ECOG performance status of 0 or 1.
  • ✓Able to swallow oral medication.
  • ✓Must have adequate laboratory parameters.
  • ✓Contraceptive use should be consistent with local regulations for those participating in clinical studies.
  • ✓Women of childbearing potential must
  • ✓Have a negative pregnancy test.
  • ✓Not be breastfeeding during treatment

Exclusion criteria

  • ✕Have known, actionable changes in the EGFR or ALK genes.
  • ✕Have another type of cancer that is progressing or required active treatment within the past 2 years before screening.
  • ✕Have an active autoimmune disease that required systemic treatment in the past 2 years. Endocrine replacement therapy is allowed.
  • ✕Had any immune-related side effect or allergic reaction (Grade 3 or higher) from a previous immunotherapy medicine, or any immune-related side effect greater than Grade 1 that has not resolved. This does not apply for people with hormone-related diseases who are now on stable hormone replacement therapy.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.