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Phase 2Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

Sponsored by Celgene

About this study

This is a study to evaluate the efficacy, safety, and tolerability of BMS-986368, a FAAH/MAGL inhibitor, for the treatment of agitation in participants with Alzheimer's Disease.

Where this study is enrolling (32)

  • University of Alabama - Huntsville Regional Medical Campus

    Huntsville, Alabama

    Call 256-551-4512

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  • Kaizen Brain Center

    La Jolla, California

    Call 214-893-0542

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  • Shreenath Clinical Service - Lakewood

    Lakewood, California

    Call 714-717-6039

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  • Next Level Clinical Trials

    West Covina, California

    Call 714-999-6688

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  • Inland Psychiatric Medical Group.

    Chino, California

    Call 909-488-9116

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Show all 32 locations

  • University of California San Diego - La Jolla

    La Jolla, California

    Call 858-246-1303

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  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado

    Call 303-724-2046

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  • Georgetown University

    Washington D.C., District of Columbia

    Call 202-687-3350

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  • Arrow Clinical Trials

    Daytona Beach, Florida

    Call 386-278-8000

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  • Charter Research - Lady Lake

    The Villages, Florida

    Call 352-775-1000

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  • ClinCloud

    Maitland, Florida

    Call 717-357-1569

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  • CenExel iResearch, LLC

    Savannah, Georgia

    Call 912-744-0800

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  • CenExel iResearch, LLC

    Decatur, Georgia

    Call 404-537-1281

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  • K2 Medical Research

    Foxborough, Massachusetts

    Call 401-435-8950

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  • Boeson Research

    Missoula, Montana

    Call 406-543-9700

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  • Be Well Clinical Studies - Omaha

    Omaha, Nebraska

    Call 402-937-9293

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  • Mid Hudson Medical Research

    New Windsor, New York

    Call 845-674-9398

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  • Research Central LLC (DBA Ichor Research)

    Syracuse, New York

    Call 315-529-0766

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  • The Feinstein Institute for Medical Research

    Manhasset, New York

    Call 516-562-3492

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  • University at Buffalo - UBMD Neurology

    Buffalo, New York

    Call 281-630-2316

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  • New Hope Clinical Research

    Charlotte, North Carolina

    Call 980-209-9784

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  • UNC Health REX Hospital

    Raleigh, North Carolina

    Call 919-784-1092

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  • Cleveland Clinic

    Cleveland, Ohio

    Call 216-403-6847

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  • Thomas Jefferson University - Vickie & Jack Farber Institute for Neuroscience

    Philadelphia, Pennsylvania

    Call 215-503-2823

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  • Vanderbilt University Medical Center- Village

    Nashville, Tennessee

    Call 601-594-0792

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  • Neurology Clinic, P.C.

    Cordova, Tennessee

    Call 901-866-9252

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  • Horizon Clinical Research Center - Houston

    Cypress, Texas

    Call 949-491-0710

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  • Be Well Clinical Studies

    Round Rock, Texas

    Call 000-000-0000

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  • Pinnacle Clinical Research

    Austin, Texas

    Call 817-602-5188

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  • Stryde Research - Plano

    Plano, Texas

    Call 214-407-8640

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  • ANESC Research

    El Paso, Texas

    Call 505-903-1715

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  • Boeson Research - Provo

    Provo, Utah

    Call 385-392-2200

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Who can participate

Inclusion criteria

  • ✓Participants with a diagnosis of Alzheimer's disease with biomarker confirmation meeting the 2024 Revised criteria for diagnosis and staging of AD: Alzheimer's Association Workgroup.
  • ✓The diagnosis of agitation must meet the International Psychogeriatric Association (IPA) definition of agitation.
  • ✓History of agitation with onset at least four weeks prior to Screening.
  • ✓MMSE-1 score ≤24.
  • ✓NPI-NH agitation/aggression sub-score ≥ 4.
  • ✓Stable living environment for at least 6 weeks prior to Screening. Participants are eligible if they are in nursing homes, assisted living facilities, or living at home and have an identified study partner (caregiver).
  • ✓Capable of self-locomotion (alone or with the aid of an assistive device); wheelchairs and other mobility aids are acceptable.

Exclusion criteria

  • ✕Clinically significant delusions/hallucinations requiring hospitalization.
  • ✕History of bipolar disorder, schizophrenia, or schizoaffective disorder.
  • ✕History of major depressive episode with psychotic features during the 12 months prior to Screening.
  • ✕History of delirium within 30 days of Screening.
  • ✕Other protocol-defined Inclusion/Exclusion criteria apply.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.