Back to Clinical Trials
Phase 2Recruiting

Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

Sponsored by Merck Sharp & Dohme LLC

About this study

Researchers are looking for new ways to treat Psoriatic Arthritis (PsA). This study will help find out if a study medicine called tulisokibart (MK-7240) can treat symptoms of active PsA. This study assesses the efficacy, safety, and tolerability of tulisokibart in adult participants with active PsA. In this study, researchers will look at different doses of tulisokibart. Researchers want to learn if at least one of the study doses of tulisokibart works better than a placebo to lessen PsA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.

This study consists of a 16-week Placebo-controlled Period and a 112-week Long-term Extension (LTE), which is composed of a 40-week Main Extension and a 72-week Optional Extension.

Where this study is enrolling (18)

  • Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 5120)

    Tucson, Arizona

    Call (480) 443-8400

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Arizona Arthritis & Rheumatology Associates, P.C. ( Site 5117)

    Sun City, Arizona

    Call 480-443-8400

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Medvin Clinical Research - Riverside ( Site 5115)

    Riverside, California

    Call 951-924-6500

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Cohen Medical Centers ( Site 5111)

    Thousand Oaks, California

    Call 877-972-7576

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Medvin Clinical Research - Tujunga ( Site 5113)

    Tujunga, California

    Call 213-281-5146

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

Show all 18 locations

  • Arthritis and Rheumatic Disease Specialties ( Site 5105)

    Aventura, Florida

    Call 305-652-6676

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • International Center for Research ( Site 5124)

    Tampa, Florida

    Call 813-392-1103

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • St. Luke's Clinic - Rheumatology - Boise ( Site 5109)

    Boise, Idaho

    Call 208-706-9088

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Arthritis and Rheumatism Associates - Rockville ( Site 5127)

    Rockville, Maryland

    Call 240-283-2046

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Johns Hopkins Bayview Medical Center - Johns Hopkins Asthma & Allergy Center ( Site 5132)

    Baltimore, Maryland

    Call 410-550-0579

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Kansas City Physician Partners ( Site 5119)

    Kansas City, Missouri

    Call 816-531-0930

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Physician Research Collaboration, LLC ( Site 5102)

    Lincoln, Nebraska

    Call 402-420-1212

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Joseph S. and Diane H. Steinberg Ambulatory Care Center ( Site 5106)

    Brooklyn, New York

    Call 929-455-2500

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Joint and Muscle Research Institute ( Site 5108)

    Charlotte, North Carolina

    Call 704-248-8577

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Altoona Center for Clinical Research ( Site 5110)

    Duncansville, Pennsylvania

    Call 814-693-0300

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Hospital of the University of Pennsylvania ( Site 5134)

    Philadelphia, Pennsylvania

    Call 215-662-2454

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Articularis Healthcare Group dba: Low Country Rheumatology ( Site 5128)

    Summerville, South Carolina

    Call 843-572-4840

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Greater Houston Rheumatology ( Site 5103)

    Houston, Texas

    Call 832-237-0400

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

Who can participate

Inclusion criteria

  • ✓The main inclusion criteria include but are not limited to the following:
  • ✓Has a clinical diagnosis of PsA and fulfillment of the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria at Screening, with symptom onset ≥6 months before Screening.
  • ✓Has a diagnosis of active plaque psoriasis or documented history of plaque psoriasis.
  • ✓Has history of biologic disease-modifying antirheumatic drug (bDMARD)-naïve or bDMARD-inadequate response/intolerant.

Exclusion criteria

  • ✕The main exclusion criteria include but are not limited to the following:
  • ✕Has any arthritis with onset before age 17 years or current diagnosis of inflammatory joint disease other than PsA (such as, but not limited to, rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, myositis, etc), or any other conditions that may, in the judgment of the investigator, interfere with the assessment of PsA.
  • ✕Has a skin condition diagnosis, other than psoriasis that may, in the judgment of the investigator, interfere with the assessment of psoriasis.
  • ✕Has a history of cancer (except fully treated nonmelanoma skin cancers or cervical carcinoma in situ after complete surgical removal) and is disease free for \<5 years before Randomization.
  • ✕Has any active infection.
  • ✕Has known allergies, hypersensitivity, or intolerance to tulisokibart of its excipients.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.