Back to Clinical Trials
Phase 2Recruiting

Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer

Sponsored by Pfizer

About this study

This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to adults with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing type of lung cancer that has spread widely in the body. To join the study, participants must meet the following conditions: * Be 18 years or older. * Have extensive-stage small cell lung cancer confirmed by lab tests. * Have not received chemotherapy or radiation for this type of lung cancer. * Be in good physical condition and have healthy organs based on medical tests. The study has two parts: * In the first part, researchers will check how safe the study medicine is and how well people tolerate it when given with chemotherapy. * In the second part, they will compare study medicine plus chemotherapy to another approved treatment (atezolizumab plus chemotherapy) to see which works better. Participants will receive the treatment through IV infusions (medicine given directly into a vein). The treatment will be given in repeated time periods called cycles. Some participants will continue receiving the study medicine alone after the initial treatment.

Where this study is enrolling (4)

  • Texas Oncology - Gulf Coast

    Houston, Texas

    Call 832-932-1730

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Texas Oncology - Gulf Coast

    Pearland, Texas

    Call 713-436-7500

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Texas Oncology - Gulf Coast

    Sugar Land, Texas

    Call 281-277-5200

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

  • Texas Oncology - Gulf Coast

    The Woodlands, Texas

    Call 281-296-0365

    This research site can be reached directly by phone. Call to ask about this study.

    Create a free account to get updates on similar Clinical Trials for your conditions.

Who can participate

Inclusion criteria

  • ✓Histologically or cytologically confirmed extensive-stage small cell lung cancer (ES-SCLC).
  • ✓Participants have not received systemic therapy (chemotherapy, radiotherapy, chemoradiation) for ES-SCLC.
  • ✓Treatment-free for at least 6 months since last chemo/radiotherapy, among those treated (with curative intent) with prior chemo/radiotherapy for limited-stage SCLC
  • ✓Have at least one measurable lesion as the targeted lesion based on RECIST V1.1.
  • ✓Eastern Cooperative Oncology Group performance status of 0 or 1.
  • ✓Adequate organ function

Exclusion criteria

  • ✕known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression
  • ✕Leptomeningeal disease
  • ✕Clinically significant risk of hemorrhage or fistula
  • ✕history of another malignancy within 3 years
  • ✕active autoimmune diseases requiring systemic treatment within the past 2 years

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.