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Phase 2Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Sponsored by National Cancer Institute (NCI)

About this study

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.

PRIMARY OBJECTIVE: I. To register, allocate, and assign patients to ComboMATCH treatment trials. SECONDARY OBJECTIVES: I. To evaluate the rate of positive outcomes in defined cohorts within treatment trials of treatment combinations including targeted therapies for molecularly defined populations, and also in the subset of treatment trials where the treatments are supported by in vivo models. II. To perform quality control of the patients registered in the form of pathological confirmation of disease and sub-type to confirm diagnosis and treatment arm allocation. SECONDARY CORRELATIVE OBJECTIVES: I. Assess the concordance of the central molecular characterization of the pre-treatment biopsy samples with the genetic readouts from the Designated Laboratories (DLs) for patients enrolled…

Where this study is enrolling (429)

  • University of South Alabama Mitchell Cancer Institute

    Mobile, Alabama

    I'm interested

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama

    I'm interested

  • Alaska Women's Cancer Care

    Anchorage, Alaska

    I'm interested

  • Kingman Regional Medical Center

    Kingman, Arizona

    I'm interested

  • CTCA at Western Regional Medical Center

    Goodyear, Arizona

    Call 623-207-3000

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Show all 429 locations

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas

    I'm interested

  • Cedars-Sinai Medical Center

    Los Angeles, California

    I'm interested

  • VA Palo Alto Health Care System

    Palo Alto, California

    Call 800-455-0057

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  • Stanford Cancer Institute Palo Alto

    Palo Alto, California

    I'm interested

  • PCR Oncology

    Arroyo Grande, California

    I'm interested

  • Mercy Cancer Center - Carmichael

    Carmichael, California

    I'm interested

  • Mercy San Juan Medical Center

    Carmichael, California

    I'm interested

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California

    I'm interested

  • UC San Diego Health System - Encinitas

    Encinitas, California

    Call 760-536-7700

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  • UC San Diego Moores Cancer Center

    La Jolla, California

    I'm interested

  • The Angeles Clinic and Research Institute - West Los Angeles Office

    Los Angeles, California

    I'm interested

  • Children's Hospital of Orange County

    Orange, California

    I'm interested

  • Saint Joseph Hospital - Orange

    Orange, California

    Call 714-734-6220

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  • Mercy Cancer Center - Rocklin

    Rocklin, California

    I'm interested

  • Mercy Cancer Center - Sacramento

    Sacramento, California

    I'm interested

  • Sharp Memorial Hospital

    San Diego, California

    I'm interested

  • Saint John's Cancer Institute

    Santa Monica, California

    Call 310-582-7448

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  • Woodland Memorial Hospital

    Woodland, California

    I'm interested

  • UC San Diego Medical Center - Hillcrest

    San Diego, California

    I'm interested

  • Medical Center of the Rockies

    Loveland, Colorado

    Call 970-203-7083

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  • UCHealth Greeley Hospital

    Greeley, Colorado

    I'm interested

  • UCHealth University of Colorado Hospital

    Aurora, Colorado

    Call 720-848-0650

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  • Poudre Valley Hospital

    Fort Collins, Colorado

    Call 970-297-6150

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  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado

    I'm interested

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware

    I'm interested

  • Helen F Graham Cancer Center

    Newark, Delaware

    I'm interested

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida

    I'm interested

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida

    Call 305-243-2647

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  • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

    North Miami, Florida

    I'm interested

  • UM Sylvester Comprehensive Cancer Center at Aventura

    Aventura, Florida

    Call 954-461-2180

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  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida

    Call 305-243-2647

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  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida

    Call 305-243-2647

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  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida

    Call 305-243-2647

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  • Broward Health Medical Center

    Fort Lauderdale, Florida

    I'm interested

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida

    Call 305-243-2647

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  • Mayo Clinic in Florida

    Jacksonville, Florida

    Call 855-776-0015

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  • The Queen's Medical Center - West Oahu

    ‘Ewa Beach, Hawaii

    I'm interested

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii

    Call 808-983-6090

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  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii

    I'm interested

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii

    Call 808-531-8521

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  • University of Hawaii Cancer Center

    Honolulu, Hawaii

    Call 808-586-2979

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  • Straub Clinic and Hospital

    Honolulu, Hawaii

    Call 808-522-4333

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  • Queen's Medical Center

    Honolulu, Hawaii

    Call 808-545-8548

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  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii

    Call 808-532-0315

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  • Pali Momi Medical Center

    ‘Aiea, Hawaii

    Call 808-486-6000

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  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii

    I'm interested

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho

    I'm interested

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho

    I'm interested

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho

    I'm interested

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho

    I'm interested

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho

    I'm interested

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, Idaho

    I'm interested

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho

    I'm interested

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho

    I'm interested

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho

    I'm interested

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho

    I'm interested

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho

    I'm interested

  • Advocate South Suburban Hospital

    Hazel Crest, Illinois

    Call 708-799-9995

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  • Illinois CancerCare-Carthage

    Carthage, Illinois

    I'm interested

  • Southern Illinois University School of Medicine

    Springfield, Illinois

    Call 217-545-7929

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  • NorthShore University HealthSystem-Highland Park Hospital

    Highland Park, Illinois

    Call 847-570-2109

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  • Mount Sinai Hospital Medical Center

    Chicago, Illinois

    I'm interested

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois

    I'm interested

  • Northwestern University

    Chicago, Illinois

    I'm interested

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois

    I'm interested

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois

    I'm interested

  • Illinois CancerCare - Washington

    Washington, Illinois

    I'm interested

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois

    I'm interested

  • Centralia Oncology Clinic

    Centralia, Illinois

    I'm interested

  • Advocate Good Shepherd Hospital

    Barrington, Illinois

    Call 847-842-4847

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  • Illinois CancerCare-Bloomington

    Bloomington, Illinois

    I'm interested

  • Illinois CancerCare-Canton

    Canton, Illinois

    I'm interested

  • SIH Cancer Institute

    Carterville, Illinois

    I'm interested

  • John H Stroger Jr Hospital of Cook County

    Chicago, Illinois

    Call (312) 864-0200

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  • University of Illinois

    Chicago, Illinois

    Call 312-355-3046

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  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois

    I'm interested

  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois

    I'm interested

  • Carle at The Riverfront

    Danville, Illinois

    I'm interested

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois

    I'm interested

  • Decatur Memorial Hospital

    Decatur, Illinois

    I'm interested

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois

    I'm interested

  • Illinois CancerCare-Dixon

    Dixon, Illinois

    Call 815-285-7800

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  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois

    I'm interested

  • Carle Physician Group-Effingham

    Effingham, Illinois

    I'm interested

  • Crossroads Cancer Center

    Effingham, Illinois

    I'm interested

  • Advocate Sherman Hospital

    Elgin, Illinois

    Call 847-429-2907

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  • Illinois CancerCare-Eureka

    Eureka, Illinois

    I'm interested

  • NorthShore University HealthSystem-Evanston Hospital

    Evanston, Illinois

    Call 847-570-2000

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  • Illinois CancerCare-Galesburg

    Galesburg, Illinois

    I'm interested

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois

    I'm interested

  • NorthShore University HealthSystem-Glenbrook Hospital

    Glenview, Illinois

    Call 847-570-2109

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  • Northwestern Medicine Glenview Outpatient Center

    Glenview, Illinois

    Call 312-695-1102

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  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois

    Call 312-695-1102

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  • Ingalls Memorial Hospital

    Harvey, Illinois

    I'm interested

  • SSM Health Good Samaritan

    Mount Vernon, Illinois

    I'm interested

  • AMG Libertyville - Oncology

    Libertyville, Illinois

    I'm interested

  • Condell Memorial Hospital

    Libertyville, Illinois

    I'm interested

  • Illinois CancerCare-Macomb

    Macomb, Illinois

    I'm interested

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois

    I'm interested

  • Loyola University Medical Center

    Maywood, Illinois

    Call 708-226-4357

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  • UC Comprehensive Cancer Center at Silver Cross

    New Lenox, Illinois

    I'm interested

  • Carle BroMenn Medical Center

    Normal, Illinois

    I'm interested

  • Carle Cancer Institute Normal

    Normal, Illinois

    I'm interested

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois

    I'm interested

  • Advocate Christ Medical Center

    Oak Lawn, Illinois

    Call 800-323-8622

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  • Northwestern Medicine Orland Park

    Orland Park, Illinois

    I'm interested

  • University of Chicago Medicine-Orland Park

    Orland Park, Illinois

    I'm interested

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois

    I'm interested

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois

    Call 847-384-3621

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  • Illinois CancerCare-Pekin

    Pekin, Illinois

    I'm interested

  • Illinois CancerCare-Peoria

    Peoria, Illinois

    I'm interested

  • Illinois CancerCare-Peru

    Peru, Illinois

    I'm interested

  • Illinois CancerCare-Princeton

    Princeton, Illinois

    I'm interested

  • Mercyhealth Cancer Institute - Rockford

    Rockford, Illinois

    I'm interested

  • Memorial Hospital East

    Shiloh, Illinois

    I'm interested

  • Springfield Clinic

    Springfield, Illinois

    Call 800-444-7541

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  • Springfield Memorial Hospital

    Springfield, Illinois

    I'm interested

  • Carle Cancer Center

    Urbana, Illinois

    I'm interested

  • Woodland Cancer Care Center

    Michigan City, Indiana

    I'm interested

  • UChicago Medicine Northwest Indiana

    Crown Point, Indiana

    I'm interested

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa

    Call 515-241-3305

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  • Mercy Hospital

    Cedar Rapids, Iowa

    Call 319-365-4673

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  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa

    Call 319-363-2690

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  • Mercy Medical Center - Des Moines

    Des Moines, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa

    Call 515-241-3305

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  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky

    Call 859-257-3379

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  • CommonSpirit Saint Joseph Medical Center - East Lexington

    Lexington, Kentucky

    I'm interested

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana

    I'm interested

  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine

    Call 800-987-3005

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  • Harold Alfond Center for Cancer Care

    Augusta, Maine

    Call 207-626-4855

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  • MaineHealth Cancer Care and IV Therapy - South Portland

    South Portland, Maine

    I'm interested

  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine

    I'm interested

  • UPMC Western Maryland

    Cumberland, Maryland

    Call 240-964-1400

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  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland

    Call 800-888-8823

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  • Walter Reed National Military Medical Center

    Bethesda, Maryland

    Call 301-319-2100

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  • National Institutes of Health Clinical Center

    Bethesda, Maryland

    Call 800-411-1222

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  • Tufts Medical Center Cancer Center Stoneham

    Stoneham, Massachusetts

    I'm interested

  • Baystate Medical Center

    Springfield, Massachusetts

    I'm interested

  • Dana-Farber Cancer Institute

    Boston, Massachusetts

    Call 877-442-3324

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  • Tufts Medical Center

    Boston, Massachusetts

    I'm interested

  • Bronson Methodist Hospital

    Kalamazoo, Michigan

    I'm interested

  • West Michigan Cancer Center

    Kalamazoo, Michigan

    I'm interested

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan

    I'm interested

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan

    I'm interested

  • Henry Ford Saint John Hospital - Macomb Medical

    Macomb, Michigan

    I'm interested

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan

    I'm interested

  • Corewell Health Lakeland Hospitals - Niles Hospital

    Niles, Michigan

    Call 616-391-1230

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  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    Norton Shores, Michigan

    I'm interested

  • Michigan Healthcare Professionals Pontiac

    Pontiac, Michigan

    I'm interested

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan

    I'm interested

  • Corewell Health Reed City Hospital

    Reed City, Michigan

    I'm interested

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan

    I'm interested

  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan

    Call 248-551-7695

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  • MyMichigan Medical Center Saginaw

    Saginaw, Michigan

    I'm interested

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    Saint Joseph, Michigan

    I'm interested

  • MyMichigan Medical Center Tawas

    Tawas City, Michigan

    I'm interested

  • Munson Medical Center

    Traverse City, Michigan

    I'm interested

  • Corewell Health Beaumont Troy Hospital

    Troy, Michigan

    Call 248-551-7695

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  • Huron Gastroenterology PC

    Ypsilanti, Michigan

    I'm interested

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan

    I'm interested

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan

    I'm interested

  • Corewell Health Children's

    Royal Oak, Michigan

    Call 248-551-7695

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  • University of Michigan Health - West

    Wyoming, Michigan

    I'm interested

  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital

    Saint Joseph, Michigan

    I'm interested

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan

    I'm interested

  • Bronson Battle Creek

    Battle Creek, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan

    I'm interested

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan

    I'm interested

  • University of Michigan - Brighton Center for Specialty Care

    Brighton, Michigan

    Call 800-865-1125

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  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan

    I'm interested

  • Trinity Health Medical Center - Canton

    Canton, Michigan

    I'm interested

  • Chelsea Hospital

    Chelsea, Michigan

    I'm interested

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan

    I'm interested

  • Corewell Health Dearborn Hospital

    Dearborn, Michigan

    Call 248-551-7695

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  • OSF Saint Francis Hospital and Medical Group

    Escanaba, Michigan

    I'm interested

  • Corewell Health Farmington Hills Hospital

    Farmington Hills, Michigan

    Call 248-551-7695

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  • Cancer Hematology Centers - Flint

    Flint, Michigan

    I'm interested

  • Genesys Hurley Cancer Institute

    Flint, Michigan

    I'm interested

  • Hurley Medical Center

    Flint, Michigan

    I'm interested

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota

    I'm interested

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota

    I'm interested

  • Mercy Hospital

    Coon Rapids, Minnesota

    I'm interested

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota

    I'm interested

  • Essentia Health Cancer Center

    Duluth, Minnesota

    I'm interested

  • Fairview Southdale Hospital

    Edina, Minnesota

    I'm interested

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota

    Call 218-786-3308

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  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota

    I'm interested

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota

    I'm interested

  • Mayo Clinic in Rochester

    Rochester, Minnesota

    Call 855-776-0015

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  • Regions Hospital

    Saint Paul, Minnesota

    I'm interested

  • United Hospital

    Saint Paul, Minnesota

    I'm interested

  • Essentia Health Virginia Clinic

    Virginia, Minnesota

    I'm interested

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota

    I'm interested

  • Essentia Health Sandstone

    Sandstone, Minnesota

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Union County

    New Albany, Mississippi

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Oxford

    Oxford, Mississippi

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Desoto

    Southhaven, Mississippi

    I'm interested

  • Baptist Cancer Center-Grenada

    Grenada, Mississippi

    I'm interested

  • Missouri Baptist Medical Center

    St Louis, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • Mercy Hospital Saint Louis

    St Louis, Missouri

    Call 314-251-7066

    This research site can be reached directly by phone. Call to ask about this study.

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  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri

    Call 314-996-5569

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  • Mercy Hospital South

    St Louis, Missouri

    I'm interested

  • Mercy Hospital Springfield

    Springfield, Missouri

    Call 417-269-4520

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  • Heartland Regional Medical Center

    Saint Joseph, Missouri

    I'm interested

  • Parkland Health Center - Farmington

    Farmington, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri

    I'm interested

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri

    I'm interested

  • Saint Luke's Hospital

    Chesterfield, Missouri

    Call 314-205-6936

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  • Saint Francis Medical Center

    Cape Girardeau, Missouri

    I'm interested

  • Washington University School of Medicine

    St Louis, Missouri

    I'm interested

  • CoxHealth South Hospital

    Springfield, Missouri

    Call 417-269-4520

    This research site can be reached directly by phone. Call to ask about this study.

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  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri

    Call 314-996-5569

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  • Siteman Cancer Center-South County

    St Louis, Missouri

    I'm interested

  • Siteman Cancer Center at Christian Hospital

    St Louis, Missouri

    I'm interested

  • Community Hospital of Anaconda

    Anaconda, Montana

    I'm interested

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana

    I'm interested

  • Billings Clinic Cancer Center

    Billings, Montana

    I'm interested

  • Community Medical Center

    Missoula, Montana

    I'm interested

  • Logan Health Medical Center

    Kalispell, Montana

    I'm interested

  • Benefis Sletten Cancer Institute

    Great Falls, Montana

    I'm interested

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada

    I'm interested

  • Renown Regional Medical Center

    Reno, Nevada

    I'm interested

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada

    I'm interested

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada

    I'm interested

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada

    I'm interested

  • Monmouth Medical Center

    Long Branch, New Jersey

    I'm interested

  • Hunterdon Medical Center

    Flemington, New Jersey

    Call 908-237-2330

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  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey

    Call 212-639-7592

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  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey

    Call 732-235-7356

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  • Community Medical Center

    Toms River, New Jersey

    I'm interested

  • Cooperman Barnabas Medical Center

    Livingston, New Jersey

    Call 973-322-5200

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  • Monmouth Medical Center Southern Campus

    Lakewood, New Jersey

    I'm interested

  • Sidney Kimmel Cancer Center Washington Township

    Sewell, New Jersey

    I'm interested

  • Robert Wood Johnson University Hospital Somerset

    Somerville, New Jersey

    I'm interested

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico

    I'm interested

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York

    I'm interested

  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York

    I'm interested

  • Roswell Park Cancer Institute

    Buffalo, New York

    I'm interested

  • State University of New York Upstate Medical University

    Syracuse, New York

    Call 315-464-5476

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  • Montefiore Medical Center - Moses Campus

    The Bronx, New York

    I'm interested

  • Memorial Sloan Kettering Commack

    Commack, New York

    Call 212-639-7592

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  • Memorial Sloan Kettering Westchester

    Harrison, New York

    Call 212-639-7592

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  • NYU Langone Hospital - Long Island

    Mineola, New York

    I'm interested

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York

    I'm interested

  • Memorial Sloan Kettering Cancer Center

    New York, New York

    Call 212-639-7592

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  • Mount Sinai Hospital

    New York, New York

    I'm interested

  • Duke Women's Cancer Care Raleigh

    Raleigh, North Carolina

    Call 919-785-4878

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  • Annie Penn Memorial Hospital

    Reidsville, North Carolina

    I'm interested

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina

    Call 336-713-6771

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  • Cone Health Cancer Center at Drawbridge Parkway

    Greensboro, North Carolina

    I'm interested

  • Hayworth Cancer Center

    High Point, North Carolina

    Call 336-802-2500

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  • Southeastern Medical Oncology Center-Jacksonville

    Jacksonville, North Carolina

    I'm interested

  • Cone Health MedCenter Asheboro

    Asheboro, North Carolina

    I'm interested

  • Cone Health Cancer Center at Alamance Regional

    Burlington, North Carolina

    I'm interested

  • Southeastern Medical Oncology Center-Clinton

    Clinton, North Carolina

    I'm interested

  • Duke University Medical Center

    Durham, North Carolina

    Call 888-275-3853

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  • Southeastern Medical Oncology Center-Goldsboro

    Goldsboro, North Carolina

    I'm interested

  • Cone Health Cancer Center

    Greensboro, North Carolina

    I'm interested

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota

    I'm interested

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota

    I'm interested

  • Sanford Broadway Medical Center

    Fargo, North Dakota

    I'm interested

  • Kettering Medical Center

    Kettering, Ohio

    I'm interested

  • Fairfield Medical Center

    Lancaster, Ohio

    I'm interested

  • OhioHealth Mansfield Hospital

    Mansfield, Ohio

    I'm interested

  • OhioHealth Marion General Hospital

    Marion, Ohio

    I'm interested

  • Memorial Hospital

    Marysville, Ohio

    I'm interested

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio

    I'm interested

  • Knox Community Hospital

    Mount Vernon, Ohio

    I'm interested

  • Licking Memorial Hospital

    Newark, Ohio

    I'm interested

  • Mercy Health - Perrysburg Hospital

    Perrysburg, Ohio

    I'm interested

  • Southern Ohio Medical Center

    Portsmouth, Ohio

    I'm interested

  • Springfield Regional Cancer Center

    Springfield, Ohio

    I'm interested

  • Mercy Health - Saint Anne Hospital

    Toledo, Ohio

    I'm interested

  • Saint Ann's Hospital

    Westerville, Ohio

    I'm interested

  • Genesis Healthcare System Cancer Care Center

    Zanesville, Ohio

    I'm interested

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio

    I'm interested

  • Strecker Cancer Center-Belpre

    Belpre, Ohio

    I'm interested

  • Aultman Health Foundation

    Canton, Ohio

    I'm interested

  • Miami Valley Hospital South

    Centerville, Ohio

    I'm interested

  • Adena Regional Medical Center

    Chillicothe, Ohio

    I'm interested

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio

    I'm interested

  • Case Western Reserve University

    Cleveland, Ohio

    I'm interested

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio

    I'm interested

  • Mount Carmel East Hospital

    Columbus, Ohio

    I'm interested

  • Columbus Oncology and Hematology Associates Inc

    Columbus, Ohio

    I'm interested

  • Riverside Methodist Hospital

    Columbus, Ohio

    I'm interested

  • Grant Medical Center

    Columbus, Ohio

    I'm interested

  • The Mark H Zangmeister Center

    Columbus, Ohio

    I'm interested

  • Doctors Hospital

    Columbus, Ohio

    I'm interested

  • Miami Valley Hospital

    Dayton, Ohio

    I'm interested

  • Premier Blood and Cancer Center

    Dayton, Ohio

    Call 937-276-8320

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  • Miami Valley Hospital North

    Dayton, Ohio

    I'm interested

  • Grady Memorial Hospital

    Delaware, Ohio

    I'm interested

  • Columbus Oncology and Hematology Associates

    Dublin, Ohio

    I'm interested

  • Dublin Methodist Hospital

    Dublin, Ohio

    I'm interested

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio

    I'm interested

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio

    Call 937-569-7515

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  • Springfield Regional Medical Center

    Springfield, Ohio

    I'm interested

  • Delaware Health Center-Grady Cancer Center

    Delaware, Ohio

    I'm interested

  • OhioHealth Westerville Medical Campus/Westerville Cancer Center

    Westerville, Ohio

    I'm interested

  • OhioHealth Pickerington Methodist Hospital

    Pickerington, Ohio

    I'm interested

  • OhioHealth O'Bleness Hospital

    Athens, Ohio

    I'm interested

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio

    Call 800-641-2422

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  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma

    I'm interested

  • Providence Saint Vincent Medical Center

    Portland, Oregon

    I'm interested

  • Providence Portland Medical Center

    Portland, Oregon

    I'm interested

  • Oregon Health and Science University

    Portland, Oregon

    I'm interested

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon

    I'm interested

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania

    Call 412-647-8073

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  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania

    I'm interested

  • UPMC-Magee Womens Hospital

    Pittsburgh, Pennsylvania

    Call 412-647-2811

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  • UPMC-Passavant Hospital

    Pittsburgh, Pennsylvania

    Call 412-367-6454

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  • Guthrie Medical Group PC-Robert Packer Hospital

    Sayre, Pennsylvania

    Call 800-836-0388

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  • Asplundh Cancer Pavilion

    Willow Grove, Pennsylvania

    I'm interested

  • Lankenau Medical Center

    Wynnewood, Pennsylvania

    I'm interested

  • Paoli Memorial Hospital

    Paoli, Pennsylvania

    I'm interested

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania

    I'm interested

  • Pennsylvania Hospital

    Philadelphia, Pennsylvania

    I'm interested

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania

    I'm interested

  • UPMC Altoona

    Altoona, Pennsylvania

    I'm interested

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania

    I'm interested

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania

    I'm interested

  • Pocono Medical Center

    East Stroudsburg, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center Erie

    Erie, Pennsylvania

    I'm interested

  • UPMC Cancer Centers - Arnold Palmer Pavilion

    Greensburg, Pennsylvania

    Call 724-838-1900

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  • Lehigh Valley Hospital-Hazleton

    Hazleton, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

    Mechanicsburg, Pennsylvania

    I'm interested

  • Riddle Memorial Hospital

    Media, Pennsylvania

    I'm interested

  • UPMC Hillman Cancer Center - Monroeville

    Monroeville, Pennsylvania

    I'm interested

  • Women and Infants Hospital

    Providence, Rhode Island

    Call 401-274-1122

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  • Roger Williams Medical Center

    Providence, Rhode Island

    I'm interested

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina

    I'm interested

  • Saint Francis Hospital

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina

    I'm interested

  • Prisma Health Richland Hospital

    Columbia, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina

    I'm interested

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina

    I'm interested

  • Saint Francis Cancer Center

    Greenville, South Carolina

    I'm interested

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota

    I'm interested

  • Rapid City Regional Hospital

    Rapid City, South Dakota

    I'm interested

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota

    I'm interested

  • Regional Cancer Center at Johnson City Medical Center

    Johnson City, Tennessee

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee

    I'm interested

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee

    Call 800-811-8480

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  • Ballad Health Cancer Care - Kingsport

    Kingsport, Tennessee

    I'm interested

  • Vanderbilt Breast Center at One Hundred Oaks

    Nashville, Tennessee

    Call 800-811-8480

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  • Hendrick Medical Center

    Abilene, Texas

    Call 325-670-6340

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  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas

    I'm interested

  • Lyndon Baines Johnson General Hospital

    Houston, Texas

    Call 713-566-5000

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  • Scott and White Memorial Hospital

    Temple, Texas

    Call 254-724-5407

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  • UT MD Anderson Cancer Center

    Houston, Texas

    I'm interested

  • University of Virginia Cancer Center

    Charlottesville, Virginia

    I'm interested

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia

    I'm interested

  • VCU Community Memorial Health Center

    South Hill, Virginia

    I'm interested

  • Carilion Roanoke Memorial Hospital

    Roanoke, Virginia

    Call 540-985-8510

    This research site can be reached directly by phone. Call to ask about this study.

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  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia

    I'm interested

  • Henrico Doctor's Hospital

    Richmond, Virginia

    Call 804-591-4152

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  • Ballad Health Cancer Care - Bristol

    Bristol, Virginia

    I'm interested

  • Inova Schar Cancer Institute

    Fairfax, Virginia

    I'm interested

  • Inova Fairfax Hospital

    Falls Church, Virginia

    I'm interested

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington

    I'm interested

  • Providence Saint Mary Regional Cancer Center

    Walla Walla, Washington

    I'm interested

  • Swedish Medical Center-First Hill

    Seattle, Washington

    I'm interested

  • Valley Medical Center

    Renton, Washington

    I'm interested

  • Providence Regional Cancer System-Lacey

    Lacey, Washington

    I'm interested

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington

    I'm interested

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington

    I'm interested

  • West Virginia University Charleston Division

    Charleston, West Virginia

    Call 304-388-9944

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  • West Virginia University Healthcare

    Morgantown, West Virginia

    I'm interested

  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia

    I'm interested

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin

    I'm interested

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin

    I'm interested

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin

    I'm interested

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin

    I'm interested

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin

    I'm interested

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin

    I'm interested

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin

    I'm interested

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    Green Bay, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin

    I'm interested

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin

    I'm interested

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin

    I'm interested

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin

    I'm interested

  • Aurora Medical Center in Summit

    Summit, Wisconsin

    I'm interested

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin

    I'm interested

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin

    I'm interested

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Berlin

    Berlin, Wisconsin

    I'm interested

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin

    I'm interested

  • Mercyhealth Hospital and Cancer Center - Janesville

    Janesville, Wisconsin

    I'm interested

  • Duluth Clinic Ashland

    Ashland, Wisconsin

    I'm interested

  • ThedaCare Regional Medical Center - Appleton

    Appleton, Wisconsin

    I'm interested

  • ThedaCare Regional Cancer Center

    Appleton, Wisconsin

    I'm interested

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Shawano

    Shawano, Wisconsin

    I'm interested

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center at Sheboygan

    Sheboygan, Wisconsin

    I'm interested

  • Sheboygan Physicians Group

    Sheboygan, Wisconsin

    I'm interested

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    Sturgeon Bay, Wisconsin

    I'm interested

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin

    I'm interested

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Waupaca

    Waupaca, Wisconsin

    I'm interested

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin

    I'm interested

  • Aurora West Allis Medical Center

    West Allis, Wisconsin

    I'm interested

  • Marshfield Medical Center - Weston

    Weston, Wisconsin

    I'm interested

  • Aurora Cancer Care-Racine

    Racine, Wisconsin

    I'm interested

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - Oshkosh

    Oshkosh, Wisconsin

    I'm interested

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center at Oconto Falls

    Oconto Falls, Wisconsin

    I'm interested

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin

    Call 262-928-7878

    This research site can be reached directly by phone. Call to ask about this study.

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  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin

    I'm interested

  • ThedaCare Cancer Care - New London

    New London, Wisconsin

    I'm interested

  • ThedaCare Regional Medical Center - Neenah

    Neenah, Wisconsin

    I'm interested
Who can participate

Inclusion criteria

  • ✓Patient must have measurable disease
  • ✓Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status between 0-2 OR patient must have Lansky performance status of \>= 50% or Karnofsky performance status of \>= 50%
  • ✓Patient must be deemed potentially eligible for a ComboMATCH Treatment Trial as assessed by the enrolling provider
  • ✓All patients must have sequencing results available from a National Cancer Institute (NCI) credentialed Designated Laboratory (DL)
  • ✓Patients must have locally advanced or advanced histologically documented solid tumors requiring therapy and meet one of the following criteria:
  • ✓Patients must have progressed on at least one line of standard systemic therapy OR
  • ✓Patients whose disease has no standard treatment that has been shown to prolong overall survival
  • ✓Patient must meet one of the following requirements:
  • ✓Patients 18 years and older who have tumor amenable to minimal risk image-guided or direct vision biopsy and must be willing and able to undergo a tumor biopsy to obtain samples for research if the patient is to enroll in a ComboMATCH treatment trial OR
  • ✓Patients 18 years and older who do not have disease that is biopsiable at minimal risk to the patient must confirm availability of an archival tumor tissue specimen for submission for research if the patient enrolls to a ComboMATCH Treatment Trial. This tumor tissue must meet the following criteria:
  • ✓Tissue must have been collected within 12 months prior to registration to the EAY191 Registration Trial
  • ✓Patient must not have had a Response Evaluation Criteria in Solid Tumors (RECIST) response (complete response \[CR\] or partial response \[PR\]) to any intervening therapy after collection of the tissue
  • ✓Formalin-fixed paraffin-embedded tumor tissue block(s) or slides must be available OR
  • ✓Patients under 18 years old must confirm availability of an archival tumor tissue specimen for submission for research if patient enrolls to a ComboMATCH Treatment Trial. This tumor tissue must meet the following criteria:
  • ✓Formalin-fixed paraffin-embedded tumor tissue block(s) or slides must be available
  • ✓NOTE: See specific ComboMATCH Treatment Trial protocol for tissue collection and management instructions. Performance of the mandatory research biopsy or submission of pre-trial formalin-fixed paraffin-embedded (FFPE) and collection and submission of the blood specimens for the integrated studies will be performed under the consent authority of the specific treatment trial protocol to which the patient is registered. No procedures to collect specimens for research only are to be performed for patients registered to the EAY191 Registration Trial only
  • ✓NOTE: Each ComboMATCH Treatment Trial contains specific eligibility criteria. If patient is found to not be eligible for the assigned ComboMATCH Treatment Trial, indication of ineligibility will trigger re-evaluation and potential assignment to another Treatment Trial

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.