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Phase 3Recruiting

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Sponsored by NRG Oncology

About this study

This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy \[IGRT\] and chemotherapy followed by immunotherapy with durvalumab or targeted therapy with osimertinib) versus the usual treatment alone in treating patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be treated by surgery (inoperable). SBRT uses special equipment to position a patient and deliver radiation therapy to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. IGRT is a type of radiation therapy that creates a picture of the tumor to help guide the radiation beam during therapy, making it more accurate and causing less damage to healthy tissue. Usual chemotherapy used in this trial consists of combinations of the following drugs: cisplatin, carboplatin, paclitaxel, nab-paclitaxel, pemetrexed, and etoposide. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds. Cisplatin works by killing, stopping, or slowing the growth of tumor cells. Carboplatin works in a way similar to the anticancer drug cisplatin but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells as well. Paclitaxel is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of tumor cells. Nab-paclitaxel is an albumin-stabilized nanoparticle formulation of paclitaxel which may have fewer side effects and work better than other forms of paclitaxel. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help tumor cells multiply. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and deoxyribonucleic acid (DNA) repair and may kill tumor cells. Immunotherapy with durvalumab can induce changes in the body's immune system and can interfere with the ability of tumor cells to grow and spread. Osimertinib is in a class of medications called kinase inhibitors. It works by blocking the action of a protein called EGFR that signals cancer cells to multiply. This helps slow or stop the spread of tumor cells. Adding SBRT to the usual treatment of IGRT with chemotherapy and immunotherapy may be more effective at treating patients with locally-advanced non-small cell lung cancer than giving the usual treatment alone.

PRIMARY OBJECTIVES: I. To compare the overall survival in patients with stage II-IIIC inoperable node-positive non-small cell lung cancer (NSCLC) after image guided, motion-managed conventional radiotherapy to the primary tumor and nodal metastases (Arm 1) or after image guided, motion-managed stereotactic body radiation therapy (SBRT) to the primary tumor followed by conventionally fractionated radiotherapy to nodal metastases (Arm 2) both given with concurrent platinum-based chemotherapy. II. To compare progression-free survival between the experimental arm (Arm 2) and control arm (Arm 1). SECONDARY OBJECTIVES: I. To compare objective response rate (as defined by Response Evaluation Criteria in Solid Tumors \[RECIST\] version \[v\] 1.1) between the experimental arm and control arm. …

Where this study is enrolling (446)

  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis

    Daphne, Alabama

    I'm interested

  • Mobile Infirmary Medical Center

    Mobile, Alabama

    Call 251-435-3942

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  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland

    Saraland, Alabama

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  • Thomas Hospital

    Fairhope, Alabama

    Call 251-435-4584

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  • The Kirklin Clinic at Acton Road

    Birmingham, Alabama

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  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama

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  • Banner University Medical Center - Tucson

    Tucson, Arizona

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  • Kingman Regional Medical Center

    Kingman, Arizona

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  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona

    Call +1 480-342-2000

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  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona

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  • Cancer Center at Saint Joseph's

    Phoenix, Arizona

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  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas

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  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas

    Call 501-686-8274

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  • Sutter Roseville Medical Center

    Roseville, California

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  • California Pacific Medical Center-Pacific Campus

    San Francisco, California

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  • Memorial Medical Center

    Modesto, California

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  • Palo Alto Medical Foundation-Fremont

    Fremont, California

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    Burlingame, California

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  • AIS Cancer Center at San Joaquin Community Hospital

    Bakersfield, California

    Call 661-323-4673

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  • Sutter Cancer Centers Radiation Oncology Services-Roseville

    Roseville, California

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  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California

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  • Palo Alto Medical Foundation Health Care

    Palo Alto, California

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    Sacramento, California

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    San Mateo, California

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    Santa Rosa, California

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    Sunnyvale, California

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    Vallejo, California

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  • UCHealth Lone Tree Health Center

    Lone Tree, Colorado

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  • UCHealth University of Colorado Hospital

    Aurora, Colorado

    Call 720-848-0650

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  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado

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  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado

    Call 719-365-2406

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  • Memorial Hospital North

    Colorado Springs, Colorado

    Call 719-364-6700

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  • UCHealth - Cherry Creek

    Denver, Colorado

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  • Poudre Valley Hospital

    Fort Collins, Colorado

    Call 970-297-6150

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  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado

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  • UCHealth Greeley Hospital

    Greeley, Colorado

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  • UCHealth Highlands Ranch Hospital

    Highlands Ranch, Colorado

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  • Medical Center of the Rockies

    Loveland, Colorado

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  • Medical Oncology Hematology Consultants PA

    Newark, Delaware

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  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware

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  • Beebe Health Campus

    Rehoboth Beach, Delaware

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    Wilmington, Delaware

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    Lewes, Delaware

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    Millville, Delaware

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  • Helen F Graham Cancer Center

    Newark, Delaware

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  • Bay Pines VA Healthcare System

    Bay Pines, Florida

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  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida

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  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida

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  • Halifax Health Cancer Center for Hope - Daytona Beach

    Daytona Beach, Florida

    Call 386-425-4213

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  • Memorial Hospital West

    Pembroke Pines, Florida

    Call 954-265-4325

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  • Orlando Health Cancer Institute

    Orlando, Florida

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  • Jupiter Medical Center

    Jupiter, Florida

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    Winter Haven, Florida

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  • Morton Plant Hospital

    Clearwater, Florida

    Call 855-314-8646

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  • Mayo Clinic in Florida

    Jacksonville, Florida

    Call 855-776-0015

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  • Emory University Hospital Midtown

    Atlanta, Georgia

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    Atlanta, Georgia

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    Atlanta, Georgia

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    Augusta, Georgia

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    Austell, Georgia

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    Dalton, Georgia

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    Marietta, Georgia

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  • CTCA at Southeastern Regional Medical Center

    Newnan, Georgia

    Call 770-400-6629

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  • Grady Health System

    Atlanta, Georgia

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  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

    Savannah, Georgia

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  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia

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  • UW Health Carbone Cancer Center Rockford

    Rockford, Illinois

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  • Advocate Sherman Hospital

    Elgin, Illinois

    Call 847-429-2907

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  • Illinois CancerCare-Eureka

    Eureka, Illinois

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  • Illinois CancerCare-Galesburg

    Galesburg, Illinois

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  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois

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  • Advocate South Suburban Hospital

    Hazel Crest, Illinois

    Call 708-799-9995

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  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois

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  • AMG Libertyville - Oncology

    Libertyville, Illinois

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  • Illinois CancerCare-Macomb

    Macomb, Illinois

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  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois

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  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois

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  • Advocate Christ Medical Center

    Oak Lawn, Illinois

    Call 800-323-8622

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  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois

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  • Advocate High Tech Medical Park

    Palos Heights, Illinois

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  • Advocate Lutheran General Hospital

    Park Ridge, Illinois

    Call 847-384-3621

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  • Illinois CancerCare-Pekin

    Pekin, Illinois

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  • Illinois CancerCare-Peoria

    Peoria, Illinois

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  • OSF Saint Francis Radiation Oncology at Peoria Cancer Center

    Peoria, Illinois

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  • Methodist Medical Center of Illinois

    Peoria, Illinois

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  • OSF Saint Francis Medical Center

    Peoria, Illinois

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  • Illinois CancerCare-Peru

    Peru, Illinois

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  • Illinois CancerCare-Princeton

    Princeton, Illinois

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  • Crossroads Cancer Center

    Effingham, Illinois

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  • Southern Illinois University School of Medicine

    Springfield, Illinois

    Call 217-545-7929

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  • Springfield Clinic

    Springfield, Illinois

    Call 800-444-7541

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  • Springfield Memorial Hospital

    Springfield, Illinois

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  • Carle Cancer Center

    Urbana, Illinois

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  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois

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  • Illinois CancerCare - Washington

    Washington, Illinois

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  • Midwestern Regional Medical Center

    Zion, Illinois

    Call 844-793-0745

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  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois

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  • Decatur Memorial Hospital

    Decatur, Illinois

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  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois

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  • Carle at The Riverfront

    Danville, Illinois

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  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois

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  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois

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  • Centralia Oncology Clinic

    Centralia, Illinois

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  • Illinois CancerCare-Carthage

    Carthage, Illinois

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  • Advocate Outpatient Center - Aurora

    Aurora, Illinois

    I'm interested

  • Advocate Good Shepherd Hospital

    Barrington, Illinois

    Call 847-842-4847

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  • HSHS Saint Elizabeth's Hospital

    O'Fallon, Illinois

    I'm interested

  • Illinois CancerCare-Canton

    Canton, Illinois

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  • Illinois CancerCare-Bloomington

    Bloomington, Illinois

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  • Northwestern University

    Chicago, Illinois

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  • Condell Memorial Hospital

    Libertyville, Illinois

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  • Rush-Copley Medical Center

    Aurora, Illinois

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  • OSF Saint Joseph Medical Center

    Bloomington, Illinois

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  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois

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  • Carle Physician Group-Effingham

    Effingham, Illinois

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  • The Community Hospital

    Munster, Indiana

    Call 219-836-3349

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  • Women's Diagnostic Center - Munster

    Munster, Indiana

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  • Saint Mary Medical Center

    Hobart, Indiana

    I'm interested

  • Northwest Cancer Center - Hobart

    Hobart, Indiana

    Call 219-947-1795

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  • Northwest Oncology LLC

    Dyer, Indiana

    Call 219-924-8178

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  • Northwest Cancer Center - Crown Point

    Crown Point, Indiana

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  • Northwest Cancer Center - Valparaiso

    Valparaiso, Indiana

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  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa

    Call 515-241-3305

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  • Mary Greeley Medical Center

    Ames, Iowa

    Call 515-956-4132

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  • McFarland Clinic - Ames

    Ames, Iowa

    I'm interested

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa

    Call 515-241-3305

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  • Saint Luke's Hospital

    Cedar Rapids, Iowa

    I'm interested

  • Mercy Cancer Center-West Lakes

    Clive, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa

    Call 515-241-3305

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  • Heartland Oncology and Hematology LLP

    Council Bluffs, Iowa

    Call 712-322-4136

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  • Methodist Jennie Edmundson Hospital

    Council Bluffs, Iowa

    I'm interested

  • Greater Regional Medical Center

    Creston, Iowa

    Call 515-241-3305

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  • Iowa Methodist Medical Center

    Des Moines, Iowa

    Call 515-241-6727

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  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa

    Call 515-241-3305

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  • Mercy Medical Center - Des Moines

    Des Moines, Iowa

    Call 515-241-3305

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  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa

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  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa

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  • Lawrence Memorial Hospital

    Lawrence, Kansas

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  • University of Kansas Cancer Center

    Kansas City, Kansas

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  • Ascension Via Christi Hospitals Wichita

    Wichita, Kansas

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  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas

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  • University of Kansas Health System Saint Francis Campus

    Topeka, Kansas

    Call 785-295-8000

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  • Salina Regional Health Center

    Salina, Kansas

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  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas

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  • The University of Kansas Cancer Center - Olathe

    Olathe, Kansas

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  • Louisiana State University Health Science Center

    New Orleans, Louisiana

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  • Touro Infirmary

    New Orleans, Louisiana

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  • University Medical Center New Orleans

    New Orleans, Louisiana

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  • MaineHealth Cancer Care and IV Therapy - South Portland

    South Portland, Maine

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  • MaineHealth Maine Medical Center - Portland

    Portland, Maine

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  • MaineHealth Cancer Care Center of York County

    Sanford, Maine

    Call 207-459-1600

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  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine

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  • William E Kahlert Regional Cancer Center/Sinai Hospital

    Westminster, Maryland

    Call 410-871-6400

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  • Greater Baltimore Medical Center

    Baltimore, Maryland

    Call 443-849-3706

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  • Sinai Hospital of Baltimore

    Baltimore, Maryland

    Call 410-601-9083

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  • TidalHealth Richard A Henson Cancer Institute

    Ocean Pines, Maryland

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  • TidalHealth Peninsula Regional

    Salisbury, Maryland

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  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts

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  • McLaren Cancer Institute-Macomb

    Mount Clemens, Michigan

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  • McLaren Cancer Institute-Central Michigan

    Mount Pleasant, Michigan

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  • Henry Ford Medical Center-Columbus

    Novi, Michigan

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  • McLaren Cancer Institute-Northern Michigan

    Petoskey, Michigan

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  • Michigan Healthcare Professionals Pontiac

    Pontiac, Michigan

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  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan

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    Port Huron, Michigan

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  • Henry Ford Health Providence Southfield Hospital

    Southfield, Michigan

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  • Munson Medical Center

    Traverse City, Michigan

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  • Michigan Healthcare Professionals Troy

    Troy, Michigan

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  • Henry Ford Health Warren Hospital

    Warren, Michigan

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  • Henry Ford West Bloomfield Hospital

    West Bloomfield, Michigan

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  • University of Michigan Health - West

    Wyoming, Michigan

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  • Michigan Healthcare Professionals Madison Heights

    Madison Heights, Michigan

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  • Michigan Healthcare Professionals Macomb

    Macomb, Michigan

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  • McLaren Cancer Institute-Lapeer Region

    Lapeer, Michigan

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  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan

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  • Karmanos Cancer Institute at McLaren Greater Lansing

    Lansing, Michigan

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  • Beacon Kalamazoo

    Kalamazoo, Michigan

    Call 574-647-7370

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  • West Michigan Cancer Center

    Kalamazoo, Michigan

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  • Bronson Methodist Hospital

    Kalamazoo, Michigan

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  • Allegiance Health

    Jackson, Michigan

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  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan

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  • McLaren Cancer Institute-Flint

    Flint, Michigan

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  • Corewell Health Farmington Hills Hospital

    Farmington Hills, Michigan

    Call 248-551-7695

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  • Weisberg Cancer Treatment Center

    Farmington Hills, Michigan

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  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan

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  • Henry Ford Medical Center-Fairlane

    Dearborn, Michigan

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  • Henry Ford Hospital

    Detroit, Michigan

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  • Michigan Healthcare Professionals Farmington

    Farmington Hills, Michigan

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  • Michigan Healthcare Professionals Clarkston

    Clarkston, Michigan

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  • McLaren Cancer Institute-Clarkston

    Clarkston, Michigan

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  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan

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  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan

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  • Corewell Health Beaumont Troy Hospital

    Troy, Michigan

    Call 248-551-7695

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  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan

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  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan

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  • Chelsea Hospital

    Chelsea, Michigan

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  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan

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  • Trinity Health Medical Center - Brighton

    Brighton, Michigan

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  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan

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  • McLaren Cancer Institute-Bay City

    Bay City, Michigan

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  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan

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  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan

    Call 248-551-7695

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  • Essentia Health Virginia Clinic

    Virginia, Minnesota

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  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota

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  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota

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  • Essentia Health - Deer River Clinic

    Deer River, Minnesota

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  • Essentia Health Cancer Center

    Duluth, Minnesota

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  • Essentia Health Saint Mary's Medical Center

    Duluth, Minnesota

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  • Miller-Dwan Hospital

    Duluth, Minnesota

    I'm interested

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota

    Call 218-786-3308

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  • Mayo Clinic in Rochester

    Rochester, Minnesota

    Call 855-776-0015

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  • Coborn Cancer Center at Saint Cloud Hospital

    Saint Cloud, Minnesota

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  • Essentia Health Sandstone

    Sandstone, Minnesota

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  • Baptist Memorial Hospital and Cancer Center-Desoto

    Southhaven, Mississippi

    I'm interested

  • Parkland Health Center - Farmington

    Farmington, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • University of Kansas Cancer Center - Briarcliff

    Kansas City, Missouri

    Call 913-588-3671

    This research site can be reached directly by phone. Call to ask about this study.

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  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • Mercy Hospital Springfield

    Springfield, Missouri

    Call 417-269-4520

    This research site can be reached directly by phone. Call to ask about this study.

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  • Mercy Hospital South

    St Louis, Missouri

    I'm interested

  • Missouri Baptist Medical Center

    St Louis, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • BJC Outpatient Center at Sunset Hills

    Sunset Hills, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri

    Call 314-996-5569

    This research site can be reached directly by phone. Call to ask about this study.

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  • Mercy Hospital Saint Louis

    St Louis, Missouri

    Call 314-251-7066

    This research site can be reached directly by phone. Call to ask about this study.

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  • University of Kansas Cancer Center - North

    Kansas City, Missouri

    I'm interested

  • University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri

    I'm interested

  • Freeman Health System

    Joplin, Missouri

    I'm interested

  • Saint Francis Medical Center

    Cape Girardeau, Missouri

    I'm interested

  • MU Health - University Hospital/Ellis Fischel Cancer Center

    Columbia, Missouri

    Call 573-882-7440

    This research site can be reached directly by phone. Call to ask about this study.

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  • Benefis Sletten Cancer Institute

    Great Falls, Montana

    I'm interested

  • Billings Clinic Cancer Center

    Billings, Montana

    I'm interested

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana

    I'm interested

  • Nebraska Methodist Hospital

    Omaha, Nebraska

    Call 402-354-5144

    This research site can be reached directly by phone. Call to ask about this study.

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  • Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

    Omaha, Nebraska

    Call 402-334-4773

    This research site can be reached directly by phone. Call to ask about this study.

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  • Renown Regional Medical Center

    Reno, Nevada

    I'm interested

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire

    I'm interested

  • Community Medical Center

    Toms River, New Jersey

    I'm interested

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey

    Call 212-639-7592

    This research site can be reached directly by phone. Call to ask about this study.

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  • Cooper Hospital University Medical Center

    Camden, New Jersey

    Call 856-325-6757

    This research site can be reached directly by phone. Call to ask about this study.

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  • Jefferson Cherry Hill Hospital

    Cherry Hill, New Jersey

    I'm interested

  • Englewood Hospital and Medical Center

    Englewood, New Jersey

    Call 201-894-3456

    This research site can be reached directly by phone. Call to ask about this study.

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  • The Cancer Institute of New Jersey Hamilton

    Hamilton, New Jersey

    Call 609-631-6946

    This research site can be reached directly by phone. Call to ask about this study.

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  • Jersey City Medical Center

    Jersey City, New Jersey

    I'm interested

  • Monmouth Medical Center Southern Campus

    Lakewood, New Jersey

    I'm interested

  • Saint Barnabas Medical Center

    Livingston, New Jersey

    I'm interested

  • Monmouth Medical Center

    Long Branch, New Jersey

    I'm interested

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey

    Call 212-639-7592

    This research site can be reached directly by phone. Call to ask about this study.

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  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey

    Call 212-639-7592

    This research site can be reached directly by phone. Call to ask about this study.

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  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey

    Call 732-235-7356

    This research site can be reached directly by phone. Call to ask about this study.

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  • Rutgers New Jersey Medical School

    Newark, New Jersey

    Call 732-235-7356

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  • Sidney Kimmel Cancer Center Washington Township

    Sewell, New Jersey

    I'm interested

  • Robert Wood Johnson University Hospital Somerset

    Somerville, New Jersey

    I'm interested

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico

    I'm interested

  • Memorial Medical Center-Las Cruces

    Las Cruces, New Mexico

    I'm interested

  • Stony Brook University Medical Center

    Stony Brook, New York

    Call 800-862-2215

    This research site can be reached directly by phone. Call to ask about this study.

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  • State University of New York Upstate Medical University

    Syracuse, New York

    Call 315-464-5476

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  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York

    I'm interested

  • Memorial Sloan Kettering Nassau

    Uniondale, New York

    Call 212-639-7592

    This research site can be reached directly by phone. Call to ask about this study.

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  • Northwell Health Cancer Institute at Huntington

    Greenlawn, New York

    Call 516-734-8896

    This research site can be reached directly by phone. Call to ask about this study.

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  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York

    I'm interested

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York

    I'm interested

  • Westchester Medical Center

    Valhalla, New York

    I'm interested

  • Wilmot Cancer Institute at Webster

    Webster, New York

    I'm interested

  • Memorial Sloan Kettering Westchester

    Harrison, New York

    Call 212-639-7592

    This research site can be reached directly by phone. Call to ask about this study.

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  • Northwell Health Imbert Cancer Center

    Bay Shore, New York

    Call 516-734-8896

    This research site can be reached directly by phone. Call to ask about this study.

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  • Sands Cancer Center

    Canandaigua, New York

    Call 585-396-6161

    This research site can be reached directly by phone. Call to ask about this study.

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  • Memorial Sloan Kettering Commack

    Commack, New York

    Call 212-639-7592

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  • Noyes Memorial Hospital/Myers Cancer Center

    Dansville, New York

    I'm interested

  • Glens Falls Hospital

    Glens Falls, New York

    Call 518-926-6700

    This research site can be reached directly by phone. Call to ask about this study.

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  • Northwell Health/Center for Advanced Medicine

    Lake Success, New York

    Call 516-734-8896

    This research site can be reached directly by phone. Call to ask about this study.

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  • New York Proton Center

    New York, New York

    I'm interested

  • Manhattan Eye Ear and Throat Hospital

    New York, New York

    Call 212-434-4460

    This research site can be reached directly by phone. Call to ask about this study.

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  • Memorial Sloan Kettering Cancer Center

    New York, New York

    Call 212-639-7592

    This research site can be reached directly by phone. Call to ask about this study.

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  • Lenox Hill Hospital

    New York, New York

    Call 516-734-8896

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  • Wilmot Cancer Institute Radiation Oncology at Greece

    Rochester, New York

    Call 585-758-7877

    This research site can be reached directly by phone. Call to ask about this study.

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  • Highland Hospital

    Rochester, New York

    Call 585-341-8113

    This research site can be reached directly by phone. Call to ask about this study.

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  • University of Rochester

    Rochester, New York

    Call 585-275-5830

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  • Staten Island University Hospital

    Staten Island, New York

    Call 718-226-8888

    This research site can be reached directly by phone. Call to ask about this study.

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  • Hayworth Cancer Center

    High Point, North Carolina

    Call 336-802-2500

    This research site can be reached directly by phone. Call to ask about this study.

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  • Levine Cancer Institute - Union West

    Matthews, North Carolina

    Call 980-442-0600

    This research site can be reached directly by phone. Call to ask about this study.

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  • Matthews Radiation Oncology Center

    Matthews, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Matthews

    Matthews, North Carolina

    I'm interested

  • Atrium Health Union/LCI-Union

    Monroe, North Carolina

    Call 980-442-2000

    This research site can be reached directly by phone. Call to ask about this study.

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  • Novant Health Cancer Institute - Mooresville

    Mooresville, North Carolina

    I'm interested

  • Rowan Regional Medical Center

    Salisbury, North Carolina

    I'm interested

  • Atrium Health Cleveland/LCI-Cleveland

    Shelby, North Carolina

    Call 800-804-9376

    This research site can be reached directly by phone. Call to ask about this study.

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  • Novant Health Cancer Institute - Statesville

    Statesville, North Carolina

    I'm interested

  • Wake Forest Baptist Health - Hematology Oncology - Statesville

    Statesville, North Carolina

    Call 704-872-3630

    This research site can be reached directly by phone. Call to ask about this study.

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  • Novant Cancer Institute Radiation Oncology - Supply

    Supply, North Carolina

    Call 910-754-4716

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  • Novant Health Cancer Institute - Thomasville

    Thomasville, North Carolina

    I'm interested

  • Wake Forest Baptist Health - Wilkes Medical Center

    Wilkesboro, North Carolina

    Call 888-716-9253

    This research site can be reached directly by phone. Call to ask about this study.

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  • Novant Health Cancer Institute Radiation Oncology - Wilmington

    Wilmington, North Carolina

    Call 910-251-1839

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  • Novant Health New Hanover Regional Medical Center

    Wilmington, North Carolina

    Call 910-342-3000

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  • Novant Health Forsyth Medical Center

    Winston-Salem, North Carolina

    I'm interested

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina

    Call 336-713-6771

    This research site can be reached directly by phone. Call to ask about this study.

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  • Levine Cancer Institute - Rutherford

    Forest City, North Carolina

    Call 800-804-9376

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  • CaroMont Regional Medical Center

    Gastonia, North Carolina

    I'm interested

  • Novant Health Breast Surgery - Greensboro

    Greensboro, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Kernersville

    Kernersville, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Huntersville

    Huntersville, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Rowan

    Salisbury, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Wilkesboro

    North Wilkesboro, North Carolina

    I'm interested

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina

    Call 800-804-9376

    This research site can be reached directly by phone. Call to ask about this study.

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  • Duke Cancer Center Raleigh

    Raleigh, North Carolina

    I'm interested

  • Novant Health Presbyterian Medical Center Huntersville

    Huntersville, North Carolina

    I'm interested

  • Novant Health Cancer Institute - Mount Airy

    Mount Airy, North Carolina

    I'm interested

  • Atrium Health Stanly/LCI-Albemarle

    Albemarle, North Carolina

    Call 800-804-9376

    This research site can be reached directly by phone. Call to ask about this study.

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  • Duke Cancer Center Cary

    Cary, North Carolina

    I'm interested

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina

    I'm interested

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina

    I'm interested

  • Atrium Health Pineville/LCI-Pineville

    Charlotte, North Carolina

    Call 980-442-2000

    This research site can be reached directly by phone. Call to ask about this study.

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  • Atrium Health University City/LCI-University

    Charlotte, North Carolina

    Call 800-804-9376

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  • Levine Cancer Institute-Ballantyne

    Charlotte, North Carolina

    Call 800-804-9376

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  • Wake Forest University at Clemmons

    Clemmons, North Carolina

    Call 888-716-9259

    This research site can be reached directly by phone. Call to ask about this study.

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  • Atrium Health Cabarrus/LCI-Concord

    Concord, North Carolina

    Call 800-804-9376

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  • Duke University Medical Center

    Durham, North Carolina

    Call 888-275-3853

    This research site can be reached directly by phone. Call to ask about this study.

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  • Sanford Bismarck Medical Center

    Bismarck, North Dakota

    I'm interested

  • Sanford Broadway Medical Center

    Fargo, North Dakota

    I'm interested

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota

    I'm interested

  • Altru Cancer Center

    Grand Forks, North Dakota

    Call 701-780-6520

    This research site can be reached directly by phone. Call to ask about this study.

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  • Cleveland Clinic Akron General

    Akron, Ohio

    I'm interested

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio

    Call 800-641-2422

    This research site can be reached directly by phone. Call to ask about this study.

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  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio

    I'm interested

  • Cleveland Clinic Mercy Hospital

    Canton, Ohio

    Call 888-293-4673

    This research site can be reached directly by phone. Call to ask about this study.

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  • Aultman Health Foundation

    Canton, Ohio

    I'm interested

  • Miami Valley Hospital South

    Centerville, Ohio

    I'm interested

  • Grant Medical Center

    Columbus, Ohio

    I'm interested

  • Doctors Hospital

    Columbus, Ohio

    I'm interested

  • Miami Valley Hospital

    Dayton, Ohio

    I'm interested

  • Premier Blood and Cancer Center

    Dayton, Ohio

    Call 937-276-8320

    This research site can be reached directly by phone. Call to ask about this study.

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  • Miami Valley Hospital North

    Dayton, Ohio

    I'm interested

  • Delaware Health Center-Grady Cancer Center

    Delaware, Ohio

    I'm interested

  • Grady Memorial Hospital

    Delaware, Ohio

    I'm interested

  • Dublin Methodist Hospital

    Dublin, Ohio

    I'm interested

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio

    I'm interested

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio

    Call 937-569-7515

    This research site can be reached directly by phone. Call to ask about this study.

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  • OhioHealth Mansfield Hospital

    Mansfield, Ohio

    I'm interested

  • OhioHealth Marion General Hospital

    Marion, Ohio

    I'm interested

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio

    I'm interested

  • Mercy Health - Perrysburg Hospital

    Perrysburg, Ohio

    I'm interested

  • Upper Valley Medical Center

    Troy, Ohio

    I'm interested

  • Case Western Reserve University

    Cleveland, Ohio

    I'm interested

  • Riverside Methodist Hospital

    Columbus, Ohio

    I'm interested

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma

    I'm interested

  • Legacy Meridian Park Hospital

    Tualatin, Oregon

    Call 503-413-1742

    This research site can be reached directly by phone. Call to ask about this study.

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  • Legacy Mount Hood Medical Center

    Gresham, Oregon

    Call 503-413-2150

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  • Legacy Good Samaritan Hospital and Medical Center

    Portland, Oregon

    I'm interested

  • Geisinger Medical Oncology-Lewisburg

    Lewisburg, Pennsylvania

    I'm interested

  • Adams Cancer Center

    Gettysburg, Pennsylvania

    Call 877-441-7957

    This research site can be reached directly by phone. Call to ask about this study.

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  • Temple University Hospital

    Philadelphia, Pennsylvania

    I'm interested

  • University of Pennsylvania/Abramson Cancer Center

    Philadelphia, Pennsylvania

    I'm interested

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania

    I'm interested

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania

    I'm interested

  • Reading Hospital

    West Reading, Pennsylvania

    Call 610-988-9323

    This research site can be reached directly by phone. Call to ask about this study.

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  • Geisinger Wyoming Valley/Henry Cancer Center

    Wilkes-Barre, Pennsylvania

    I'm interested

  • Asplundh Cancer Pavilion

    Willow Grove, Pennsylvania

    I'm interested

  • Lankenau Medical Center

    Wynnewood, Pennsylvania

    I'm interested

  • WellSpan Health-York Cancer Center

    York, Pennsylvania

    Call 877-441-7957

    This research site can be reached directly by phone. Call to ask about this study.

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  • WellSpan Health-York Hospital

    York, Pennsylvania

    Call 877-441-7957

    This research site can be reached directly by phone. Call to ask about this study.

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  • Penn State Milton S Hershey Medical Center

    Hershey, Pennsylvania

    I'm interested

  • Ephrata Cancer Center

    Ephrata, Pennsylvania

    Call 717-721-4840

    This research site can be reached directly by phone. Call to ask about this study.

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  • Christiana Care Health System-Concord Health Center

    Chadds Ford, Pennsylvania

    I'm interested

  • Chambersburg Hospital

    Chambersburg, Pennsylvania

    I'm interested

  • Geisinger Medical Center

    Danville, Pennsylvania

    I'm interested

  • Geisinger Cancer Center Dickson City

    Dickson City, Pennsylvania

    I'm interested

  • Lancaster General Ann B Barshinger Cancer Institute

    Lancaster, Pennsylvania

    I'm interested

  • Sechler Family Cancer Center

    Lebanon, Pennsylvania

    I'm interested

  • Lexington Medical Center

    West Columbia, South Carolina

    I'm interested

  • Spartanburg Medical Center

    Spartanburg, South Carolina

    I'm interested

  • Lancaster Radiation Therapy Center

    Lancaster, South Carolina

    Call 800-804-9376

    This research site can be reached directly by phone. Call to ask about this study.

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  • Rock Hill Radiation Therapy Center

    Rock Hill, South Carolina

    Call 800-804-9376

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  • Levine Cancer Institute-Rock Hill

    Rock Hill, South Carolina

    Call 800-804-9376

    This research site can be reached directly by phone. Call to ask about this study.

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  • SMC Center for Hematology Oncology Union

    Union, South Carolina

    I'm interested

  • Saint Joseph's/Candler - Bluffton Campus

    Bluffton, South Carolina

    I'm interested

  • Gibbs Cancer Center-Gaffney

    Gaffney, South Carolina

    I'm interested

  • Saint Francis Hospital

    Greenville, South Carolina

    I'm interested

  • Saint Francis Cancer Center

    Greenville, South Carolina

    I'm interested

  • Gibbs Cancer Center-Pelham

    Greer, South Carolina

    I'm interested

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota

    I'm interested

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee

    I'm interested

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee

    I'm interested

  • University of Tennessee - Knoxville

    Knoxville, Tennessee

    Call 865-544-9773

    This research site can be reached directly by phone. Call to ask about this study.

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  • MD Anderson in Sugar Land

    Sugar Land, Texas

    I'm interested

  • UT MD Anderson - League City

    League City, Texas

    I'm interested

  • MD Anderson West Houston

    Houston, Texas

    I'm interested

  • UT MD Anderson Cancer Center

    Houston, Texas

    I'm interested

  • Ben Taub General Hospital

    Houston, Texas

    Call 713-873-2000

    This research site can be reached directly by phone. Call to ask about this study.

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  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas

    I'm interested

  • MD Anderson in The Woodlands

    Conroe, Texas

    I'm interested

  • Dartmouth Cancer Center - North

    Saint Johnsbury, Vermont

    I'm interested

  • University of Vermont and State Agricultural College

    Burlington, Vermont

    I'm interested

  • University of Vermont Medical Center

    Burlington, Vermont

    I'm interested

  • Central Vermont Medical Center/National Life Cancer Treatment

    Berlin Corners, Vermont

    Call 802-225-5400

    This research site can be reached directly by phone. Call to ask about this study.

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  • Legacy Cancer Institute Medical Oncology and Day Treatment

    Vancouver, Washington

    I'm interested

  • Virginia Mason Medical Center

    Seattle, Washington

    I'm interested

  • Legacy Salmon Creek Hospital

    Vancouver, Washington

    Call 503-413-2150

    This research site can be reached directly by phone. Call to ask about this study.

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  • West Virginia University Healthcare

    Morgantown, West Virginia

    I'm interested

  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia

    I'm interested

  • Aspirus Regional Cancer Center

    Wausau, Wisconsin

    Call 877-405-6866

    This research site can be reached directly by phone. Call to ask about this study.

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  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin

    I'm interested

  • Langlade Hospital and Cancer Center

    Antigo, Wisconsin

    I'm interested

  • Essentia Health Saint Mary's Hospital - Superior

    Superior, Wisconsin

    Call 701-364-6272

    This research site can be reached directly by phone. Call to ask about this study.

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  • Aurora Medical Center in Summit

    Summit, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    Sturgeon Bay, Wisconsin

    I'm interested

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin

    I'm interested

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin

    I'm interested

  • University of Wisconsin Carbone Cancer Center - Johnson Creek

    Johnson Creek, Wisconsin

    I'm interested

  • Aspirus Cancer Care - Stevens Point

    Stevens Point, Wisconsin

    I'm interested

  • Essentia Health-Spooner Clinic

    Spooner, Wisconsin

    I'm interested

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center at Sheboygan

    Sheboygan, Wisconsin

    I'm interested

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin

    I'm interested

  • Aspirus Cancer Care - James Beck Cancer Center

    Rhinelander, Wisconsin

    I'm interested

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin

    I'm interested

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin

    Call 262-928-7878

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  • Drexel Town Square Health Center

    Oak Creek, Wisconsin

    Call 414-805-0505

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  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin

    I'm interested

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin

    I'm interested

  • Zablocki Veterans Administration Medical Center

    Milwaukee, Wisconsin

    Call 888-469-6614

    This research site can be reached directly by phone. Call to ask about this study.

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  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin

    I'm interested

  • Medical College of Wisconsin

    Milwaukee, Wisconsin

    Call 414-805-3666

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  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin

    I'm interested

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin

    I'm interested

  • Froedtert Menomonee Falls Hospital

    Menomonee Falls, Wisconsin

    Call 262-257-5100

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  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin

    I'm interested

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin

    I'm interested

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin

    I'm interested

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin

    I'm interested

  • William S Middleton VA Medical Center

    Madison, Wisconsin

    Call 608-256-1901

    This research site can be reached directly by phone. Call to ask about this study.

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  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin

    I'm interested

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin

    I'm interested

  • Essentia Health-Hayward Clinic

    Hayward, Wisconsin

    I'm interested

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin

    I'm interested

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin

    I'm interested

  • Duluth Clinic Ashland

    Ashland, Wisconsin

    I'm interested

  • Marshfield Medical Center - Weston

    Weston, Wisconsin

    I'm interested

  • Aspirus Cancer Care - Wisconsin Rapids

    Wisconsin Rapids, Wisconsin

    Call 715-422-7718

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  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin

    I'm interested

  • Northwest Wisconsin Cancer Center

    Ashland, Wisconsin

    I'm interested

  • Aurora Cancer Care-Racine

    Racine, Wisconsin

    I'm interested

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin

    I'm interested

  • Aurora Saint Luke's South Shore

    Cudahy, Wisconsin

    I'm interested

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin

    I'm interested

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    West Bend, Wisconsin

    Call 414-805-0505

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  • Aurora West Allis Medical Center

    West Allis, Wisconsin

    I'm interested

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin

    I'm interested
Who can participate

Inclusion criteria

  • ✓Pathologically (histologically or cytologically) proven diagnosis of non-operable stage IIB or III, node positive (American Joint Committee on Cancer \[AJCC\] eighth edition) non-small cell lung cancer (NSCLC) with known PD-L1 status prior to registration
  • ✓Patients must have an identified primary tumor and at least one nodal metastasis (peribronchial/hilar/intrapulmonary, mediastinal/subcarinal, supraclavicular/scalene)
  • ✓Up to 4 cycles of systemic therapy received prior to registration for the current study cancer is allowable; any prior chemotherapy for a different cancer is also permissible
  • ✓Patients who refuse surgery, in addition to those who are technically unresectable or medically inoperable, are eligible.
  • ✓Patients with separate tumor nodules in the same lobe of the primary tumor are eligible
  • ✓The patient must be deemed clinically appropriate for curative intent definitive combined modality therapy, based on the following staging assessments:
  • ✓History/physical examination prior to registration;
  • ✓Magnetic resonance imaging (MRI) scan of the brain (preferred) or CT scan of the brain (if available, contrast is preferred for all neuroimaging) prior to registration;
  • ✓CT chest with IV contrast (if contrast is available and unless contraindicated, such as for abnormal kidney function) prior to registration. PET/CT may be used if the CT portion is of identical diagnostic quality as achieved in a stand-alone CT
  • ✓No evidence of distant metastases based on FDG PET/CT scan obtained within 60 days of registration
  • ✓Primary tumor =\< 7 cm
  • ✓Age \>= 18
  • ✓Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • ✓Hematologic function (e.g. platelets, leukocytes, hemoglobin) amenable, at the discretion of the treating physician, to allow for treatment with chemotherapy and concurrent radiation therapy
  • ✓Creatinine clearance \>= 25 mL/min by the Cockcroft-Gault (C-G) equation
  • ✓Subjects with non-malignant pleural effusion are eligible provided the effusion is not known or demonstrated to be an exudative effusion
  • ✓If a pleural effusion is present, the following criteria must be met to exclude malignant involvement:
  • ✓When pleural fluid is visible on both the CT scan and on a chest x-ray, a pleuracentesis is required to confirm that the pleural fluid is cytologically negative;
  • ✓Effusions that are minimal (i.e., not visible on chest x-ray) that are too small to safely tap are eligible
  • ✓Medical history consistent with the patient being amenable, at the discretion of the treating physician, to allow for treating with consolidation immunotherapy. Patients with known EGFR/ALK/other driver mutation at the time of registration are eligible, and these patients can be treated with consolidation systemic therapy at the discretion of the treating physician
  • ✓Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen
  • ✓Negative pregnancy test =\< 14 days prior to registration for participants of childbearing potential
  • ✓The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

Exclusion criteria

  • ✕Prior radiotherapy to the study cancer (local recurrence). Prior radiotherapy for a different cancer/condition to the region of the study cancer that would result in overlap of radiation therapy fields that is determined by the treating physician to impede the treatment of the study malignancy
  • ✕Patients without identifiable primary tumor and at least 1 pathologically enlarged lymph node are not eligible (T3-4N0 or T0N1-3 patients are not eligible). At least 1 radiographically-involved lymph node is required, but pathologic confirmation of involvement is not mandated
  • ✕Centrally located primary tumor \< 2 cm from involved nodal disease that would result in significant overlap of the primary SBRT and nodal radiation fields. This does not include proximity to involved segmental and subsegmental lymph nodes (levels 13 and 14) that would not result in overlap of dose to the proximal bronchial tree or esophagus. Centrally located is defined as within or touching the zone of the proximal bronchial tree, which is a volume 2 cm in all directions around the proximal bronchial tree (carina, right and left main bronchi, right and left upper lobe bronchi, intermedius bronchus, right middle lobe bronchus, lingular bronchus right and left lower lobe bronchi)
  • ✕Participants who are pregnant or unwilling to discontinue nursing
  • ✕Participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) unwilling to use highly effective contraceptives during therapy and for the Food and Drug Administration (FDA)-labeled contraception timeframe required after the final dose of the selected systemic therapy regimen, because the treatment in this study may be significantly teratogenic

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.