The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study
Sponsored by Children's Hospital Medical Center, Cincinnati
About this study
The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every 12 hours) and (2) pharmacokinetically-guided precision-dosing of MMF (MMFPK; MMF dosed twice daily to achieve an area under the concentration-time curve (AUC0-12h) of MPA \>60-70 mg\*h/L. The study goal is to determine the safety and efficacy of MMFPK compared to MMFBSA for the treatment of proliferative LN in subjects 8 to \<21 years.
Enrolling at this location
University Hospitals Cleveland Medical Center
Cleveland, Ohio
I'm interestedThis study also enrolls at 18 other locations. See all.
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Trial data sourced from ClinicalTrials.gov.