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Phase 3Recruiting

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Sponsored by Children's Oncology Group

About this study

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.

PRIMARY OBJECTIVE: I. To determine if open surgical resection is superior to thoracoscopic resection for thoracic event-free survival (tEFS) in patients with resectable oligometastatic pulmonary osteosarcoma. SECONDARY OBJECTIVES: I. To determine if open surgical resection is superior to thoracoscopy for event free survival (EFS) in patients with resectable oligometastatic pulmonary osteosarcoma. II. To determine if open surgical resection is superior to thoracoscopy for overall survival (OS) in patients with resectable oligometastatic pulmonary osteosarcoma. EXPLORATORY OBJECTIVES: I. To compare 30-day rates of perioperative surgical complications for both open surgical resection and thoracoscopy. II. To compare patterns of recurrence (ipsilateral and/or contralateral) in patients …

Where this study is enrolling (202)

  • Children's Hospital of Alabama

    Birmingham, Alabama

    I'm interested

  • Providence Alaska Medical Center

    Anchorage, Alaska

    I'm interested

  • Phoenix Childrens Hospital

    Phoenix, Arizona

    Call 602-933-1000

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  • Banner University Medical Center - Tucson

    Tucson, Arizona

    I'm interested

  • Banner Children's at Desert

    Mesa, Arizona

    Call 480-412-3100

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Show all 202 locations

  • Kingman Regional Medical Center

    Kingman, Arizona

    I'm interested

  • Arkansas Children's Hospital

    Little Rock, Arkansas

    Call 501-364-7373

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  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California

    I'm interested

  • Kaiser Permanente-Anaheim

    Anaheim, California

    I'm interested

  • Kaiser Permanente-Bellflower

    Bellflower, California

    I'm interested

  • UCSF Medical Center-Mission Bay

    San Francisco, California

    I'm interested

  • Rady Children's Hospital - San Diego

    San Diego, California

    Call 858-966-5934

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  • Kaiser Permanente-San Diego Zion

    San Diego, California

    I'm interested

  • Kaiser Permanente-Oakland

    Oakland, California

    I'm interested

  • Kaiser Permanente-Fontana

    Fontana, California

    I'm interested

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California

    Call 562-933-5600

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  • Kaiser Permanente Downey Medical Center

    Downey, California

    Call 626-564-3455

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  • Cedars-Sinai Medical Center

    Los Angeles, California

    I'm interested

  • PCR Oncology

    Arroyo Grande, California

    I'm interested

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California

    Call 916-734-3089

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  • Children's Hospital Los Angeles

    Los Angeles, California

    Call 323-361-4110

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  • Loma Linda University Medical Center

    Loma Linda, California

    Call 909-558-4050

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  • Children's Hospital of Orange County

    Orange, California

    I'm interested

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California

    I'm interested

  • Valley Children's Hospital

    Madera, California

    I'm interested

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado

    I'm interested

  • Children's Hospital Colorado

    Aurora, Colorado

    I'm interested

  • Connecticut Children's Medical Center

    Hartford, Connecticut

    Call 860-545-9981

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  • Smilow Cancer Center/Yale-New Haven Hospital

    New Haven, Connecticut

    I'm interested

  • Yale University

    New Haven, Connecticut

    I'm interested

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware

    I'm interested

  • Children's National Medical Center

    Washington D.C., District of Columbia

    I'm interested

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida

    I'm interested

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida

    I'm interested

  • Arnold Palmer Hospital for Children

    Orlando, Florida

    I'm interested

  • Tampa General Hospital

    Tampa, Florida

    I'm interested

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida

    I'm interested

  • Nicklaus Children's Hospital

    Miami, Florida

    Call 888-624-2778

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  • Nemours Children's Hospital

    Orlando, Florida

    I'm interested

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida

    I'm interested

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia

    I'm interested

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii

    Call 808-983-6090

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  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho

    I'm interested

  • OSF Children's Hospital of Illinois

    Peoria, Illinois

    I'm interested

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois

    I'm interested

  • Northwestern Medicine Central DuPage Hospital

    Winfield, Illinois

    I'm interested

  • University of Illinois

    Chicago, Illinois

    Call 312-355-3046

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  • Lurie Children's Hospital-Chicago

    Chicago, Illinois

    I'm interested

  • Loyola University Medical Center

    Maywood, Illinois

    Call 708-226-4357

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  • Riley Hospital for Children

    Indianapolis, Indiana

    Call 800-248-1199

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  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa

    Call 800-237-1225

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  • Blank Children's Hospital

    Des Moines, Iowa

    I'm interested

  • Norton Children's Hospital

    Louisville, Kentucky

    I'm interested

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky

    Call 859-257-3379

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  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana

    I'm interested

  • Children's Hospital New Orleans

    New Orleans, Louisiana

    Call 504-894-5377

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  • Eastern Maine Medical Center

    Bangor, Maine

    Call 207-973-4274

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  • Maine Children's Cancer Program

    Scarborough, Maine

    I'm interested

  • Sinai Hospital of Baltimore

    Baltimore, Maryland

    Call 410-601-9083

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  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland

    I'm interested

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland

    Call 800-888-8823

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  • Walter Reed National Military Medical Center

    Bethesda, Maryland

    Call 301-319-2100

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  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts

    Call 877-726-5130

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  • Dana-Farber Cancer Institute

    Boston, Massachusetts

    Call 877-442-3324

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  • Corewell Health Lakeland Hospitals - Niles Hospital

    Niles, Michigan

    Call 616-391-1230

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  • Beacon Kalamazoo Cancer Center

    Kalamazoo, Michigan

    Call 574-647-7370

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  • Beacon Kalamazoo

    Kalamazoo, Michigan

    Call 574-647-7370

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  • Bronson Battle Creek

    Battle Creek, Michigan

    I'm interested

  • Bronson Methodist Hospital

    Kalamazoo, Michigan

    I'm interested

  • C S Mott Children's Hospital

    Ann Arbor, Michigan

    Call 800-865-1125

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  • Children's Hospital of Michigan

    Detroit, Michigan

    I'm interested

  • Corewell Health Children's

    Royal Oak, Michigan

    Call 248-551-7695

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  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan

    I'm interested

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan

    I'm interested

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    Saint Joseph, Michigan

    I'm interested

  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital

    Saint Joseph, Michigan

    I'm interested

  • Corewell Health Reed City Hospital

    Reed City, Michigan

    I'm interested

  • Munson Medical Center

    Traverse City, Michigan

    I'm interested

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan

    I'm interested

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan

    I'm interested

  • University of Michigan Health - West

    Wyoming, Michigan

    I'm interested

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan

    I'm interested

  • West Michigan Cancer Center

    Kalamazoo, Michigan

    I'm interested

  • Mayo Clinic in Rochester

    Rochester, Minnesota

    Call 855-776-0015

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  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota

    Call 612-624-2620

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  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota

    I'm interested

  • University of Mississippi Medical Center

    Jackson, Mississippi

    Call 601-815-6700

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  • University of Missouri Children's Hospital

    Columbia, Missouri

    I'm interested

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri

    Call 314-268-4000

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  • Washington University School of Medicine

    St Louis, Missouri

    I'm interested

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri

    I'm interested

  • Mercy Hospital Saint Louis

    St Louis, Missouri

    Call 314-251-7066

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  • University of Nebraska Medical Center

    Omaha, Nebraska

    I'm interested

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska

    Call 402-955-3949

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  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada-Summerlin

    Las Vegas, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada-Southeast Henderson

    Henderson, Nevada

    I'm interested

  • Oncology Las Vegas - Henderson

    Henderson, Nevada

    I'm interested

  • Oncology Las Vegas - Tenaya

    Las Vegas, Nevada

    I'm interested

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada

    I'm interested

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada

    I'm interested

  • OptumCare Cancer Care at MountainView

    Las Vegas, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada-Horizon Ridge

    Henderson, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada - Town Center

    Las Vegas, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada - Northwest

    Las Vegas, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada - Henderson

    Henderson, Nevada

    I'm interested

  • Radiation Oncology Centers of Nevada Central

    Las Vegas, Nevada

    I'm interested

  • Radiation Oncology Centers of Nevada Southeast

    Las Vegas, Nevada

    I'm interested

  • Comprehensive Cancer Centers of Nevada - Central Valley

    Las Vegas, Nevada

    I'm interested

  • Renown Regional Medical Center

    Reno, Nevada

    I'm interested

  • Saint Mary's Regional Medical Center

    Reno, Nevada

    I'm interested

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada

    I'm interested

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada

    I'm interested

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada

    I'm interested

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada

    I'm interested

  • Carson Tahoe Regional Medical Center

    Carson City, Nevada

    I'm interested

  • Urology Specialists of Nevada - Central

    Las Vegas, Nevada

    I'm interested

  • Urology Specialists of Nevada - Green Valley

    Henderson, Nevada

    I'm interested

  • Urology Specialists of Nevada - Northwest

    Las Vegas, Nevada

    I'm interested

  • Urology Specialists of Nevada - Southwest

    Las Vegas, Nevada

    I'm interested

  • Hope Cancer Care of Nevada

    Las Vegas, Nevada

    I'm interested

  • Hope Cancer Care of Nevada-Pahrump

    Pahrump, Nevada

    I'm interested

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire

    I'm interested

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey

    Call 732-235-8675

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  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey

    I'm interested

  • Saint Peter's University Hospital

    New Brunswick, New Jersey

    I'm interested

  • Morristown Medical Center

    Morristown, New Jersey

    Call 973-971-5900

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  • Hackensack University Medical Center

    Hackensack, New Jersey

    Call 551-996-2897

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  • Presbyterian Hospital

    Albuquerque, New Mexico

    I'm interested

  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York

    I'm interested

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York

    I'm interested

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York

    Call 718-470-3460

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  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York

    I'm interested

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York

    I'm interested

  • New York Medical College

    Valhalla, New York

    Call 914-594-3794

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  • Albany Medical Center

    Albany, New York

    Call 518-262-5513

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  • Mount Sinai Hospital

    New York, New York

    I'm interested

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York

    I'm interested

  • Maimonides Medical Center

    Brooklyn, New York

    Call 718-765-2500

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  • Memorial Sloan Kettering Cancer Center

    New York, New York

    Call 212-639-7592

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  • Children's Hospital at Montefiore

    The Bronx, New York

    I'm interested

  • State University of New York Upstate Medical University

    Syracuse, New York

    Call 315-464-5476

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  • Stony Brook University Medical Center

    Stony Brook, New York

    Call 800-862-2215

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  • Mission Hospital

    Asheville, North Carolina

    I'm interested

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina

    Call 336-713-6771

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  • Duke University Medical Center

    Durham, North Carolina

    Call 888-275-3853

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  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina

    I'm interested

  • East Carolina University

    Greenville, North Carolina

    I'm interested

  • Sanford Broadway Medical Center

    Fargo, North Dakota

    I'm interested

  • Nationwide Children's Hospital

    Columbus, Ohio

    I'm interested

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio

    I'm interested

  • Children's Hospital Medical Center of Akron

    Akron, Ohio

    Call 330-543-3193

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  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio

    Call 216-844-5437

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  • Dayton Children's Hospital

    Dayton, Ohio

    Call 800-228-4055

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  • Cleveland Clinic Foundation

    Cleveland, Ohio

    I'm interested

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio

    I'm interested

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma

    I'm interested

  • Oregon Health and Science University

    Portland, Oregon

    I'm interested

  • Legacy Emanuel Children's Hospital

    Portland, Oregon

    Call 503-413-2560

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  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania

    I'm interested

  • Geisinger Medical Center

    Danville, Pennsylvania

    I'm interested

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania

    I'm interested

  • Penn State Children's Hospital

    Hershey, Pennsylvania

    Call 717-531-6012

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  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania

    I'm interested

  • Rhode Island Hospital

    Providence, Rhode Island

    Call 401-444-1488

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  • Prisma Health Richland Hospital

    Columbia, South Carolina

    I'm interested

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina

    I'm interested

  • Medical University of South Carolina

    Charleston, South Carolina

    I'm interested

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota

    I'm interested

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee

    Call 800-811-8480

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  • East Tennessee Childrens Hospital

    Knoxville, Tennessee

    Call 865-541-8266

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  • Saint Jude Children's Research Hospital

    Memphis, Tennessee

    I'm interested

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee

    Call 615-342-1919

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  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas

    I'm interested

  • Cook Children's Medical Center

    Fort Worth, Texas

    I'm interested

  • Medical City Dallas Hospital

    Dallas, Texas

    Call 972-566-5588

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  • Dell Children's Medical Center of Central Texas

    Austin, Texas

    I'm interested

  • Driscoll Children's Hospital

    Corpus Christi, Texas

    I'm interested

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas

    I'm interested

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas

    I'm interested

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas

    I'm interested

  • El Paso Children's Hospital

    El Paso, Texas

    I'm interested

  • UT MD Anderson Cancer Center

    Houston, Texas

    I'm interested

  • Children's Hospital of San Antonio

    San Antonio, Texas

    I'm interested

  • Primary Children's Hospital

    Salt Lake City, Utah

    Call 801-585-5270

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  • Inova Fairfax Hospital

    Falls Church, Virginia

    I'm interested

  • Carilion Children's

    Roanoke, Virginia

    I'm interested

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia

    I'm interested

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia

    I'm interested

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia

    I'm interested

  • University of Virginia Cancer Center

    Charlottesville, Virginia

    I'm interested

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington

    I'm interested

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington

    I'm interested

  • Madigan Army Medical Center

    Tacoma, Washington

    I'm interested

  • Mary Bridge Children's Hospital and Health Center

    Tacoma, Washington

    I'm interested

  • Seattle Children's Hospital

    Seattle, Washington

    Call 866-987-2000

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  • Valley Medical Center

    Renton, Washington

    I'm interested

  • West Virginia University Healthcare

    Morgantown, West Virginia

    I'm interested

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin

    I'm interested

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin

    I'm interested

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin

    I'm interested

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin

    I'm interested
Who can participate

Inclusion criteria

  • ✓Patients must be \< 50 years at the time of enrollment.
  • ✓Patients must have =\< 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being \>= 3 mm and all of which must be =\< 3 cm size.
  • ✓Note: Patient must have eligibility confirmed by rapid central imaging review.
  • ✓Lung nodules must be considered resectable by either open thoracotomy or thoracoscopic surgery. Determination of resectability is made by the institutional surgeon.
  • ✓Patients must have a histological diagnosis of osteosarcoma.
  • ✓Patients must have evidence of metastatic lung disease at the time of initial diagnosis, or at time of 1st recurrence following completion of therapy for initially localized disease.
  • ✓Patients with newly diagnosed disease must have completed successful gross tumor resection for their primary tumor or surgical local control of primary tumor must be planned to be performed simultaneously with thoracic surgery.
  • ✓Newly diagnosed patients must be receiving or recently completed (within 60 days) systemic therapy considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.
  • ✓Patients at time of 1st recurrence must have completed systemic therapy for their initial primary tumor, considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.

Exclusion criteria

  • ✕Patients with unresectable primary tumor.
  • ✕Patients with pulmonary metastatic lesions that would require anatomic resection (lobectomy or pneumonectomy) or lesions that are defined as "central" (i.e., central lesion involves or is proximal to segmental bronchi and peripheral is lesion distal to segmental bronchi).
  • ✕Patients with chest wall or mediastinal based metastatic lesions, or with significant pleural effusion.
  • ✕Patients with disease progression at either the primary or pulmonary metastatic site while on initial therapy. Note: Once the patient has been enrolled on the study, additional computed tomography (CT) scans are not anticipated prior to thoracic surgery. Note: Some variation in nodule size measurements over the course of pre-operative therapy is anticipated and does not qualify for exclusion unless deemed true disease progression by the primary treatment team.
  • ✕Patients with evidence of extrapulmonary metastatic disease.
  • ✕Patients who received therapeutic pulmonary surgery for lung metastasis prior to enrollment.
  • ✕All patients and/or their parents or legal guardians must sign a written informed consent.
  • ✕All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.

Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.

Trial data sourced from ClinicalTrials.gov.